scholarly journals Inflammatory monocytes contribute to the persistence of CXCR3hi CX3CR1lo circulating and lung-resident memory CD8+ T cells following respiratory virus infection

2018 ◽  
Vol 96 (4) ◽  
pp. 370-378 ◽  
Author(s):  
Pritesh Desai ◽  
Vikas Tahiliani ◽  
Jessica Stanfield ◽  
Georges Abboud ◽  
Shahram Salek-Ardakani
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cd8 T Cells ◽  
Respiratory Virus ◽  
Memory Cd8 T Cells ◽  
Inflammatory Monocytes ◽  
Respiratory Virus Infection

scholarly journals The route of priming influences the ability of respiratory virus–specific memory CD8+ T cells to be activated by residual antigen

2010 ◽  
Vol 207 (6) ◽  
pp. 1153-1160 ◽  
Author(s):  
Shiki Takamura ◽  
Alan D. Roberts ◽  
Dawn M. Jelley-Gibbs ◽  
Susan T. Wittmer ◽  
Jacob E. Kohlmeier ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cd8 T Cells ◽  
Respiratory Virus ◽  
Virus Infections ◽  
Memory Cd8 T Cells ◽  
Virus Clearance ◽  
Specific Memory ◽  
Respiratory Virus Infections ◽  
Lung Airways

After respiratory virus infections, memory CD8+ T cells are maintained in the lung airways by a process of continual recruitment. Previous studies have suggested that this process is controlled, at least in the initial weeks after virus clearance, by residual antigen in the lung-draining mediastinal lymph nodes (MLNs). We used mouse models of influenza and parainfluenza virus infection to show that intranasally (i.n.) primed memory CD8+ T cells possess a unique ability to be reactivated by residual antigen in the MLN compared with intraperitoneally (i.p.) primed CD8+ T cells, resulting in the preferential recruitment of i.n.-primed memory CD8+ T cells to the lung airways. Furthermore, we demonstrate that the inability of i.p.-primed memory CD8+ T cells to access residual antigen can be corrected by a subsequent i.n. virus infection. Thus, two independent factors, initial CD8+ T cell priming in the MLN and prolonged presentation of residual antigen in the MLN, are required to maintain large numbers of antigen-specific memory CD8+ T cells in the lung airways.

Mice Lacking CD8+ T Cells Develop Greater Numbers of IgA-Producing Cells in Response to a Respiratory Virus Infection

Virology ◽  
1994 ◽  
Vol 204 (1) ◽  
pp. 234-241 ◽  
Author(s):  
L. Hyland ◽  
S. Hou ◽  
C. Coleclough ◽  
T. Takimoto ◽  
P.C. Doherty
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cd8 T Cells ◽  
Respiratory Virus ◽  
Respiratory Virus Infection

scholarly journals Clonally Related CD8+T Cells Responsible for Rapid Population of Both Diffuse Nasal-Associated Lymphoid Tissue and Lung After Respiratory Virus Infection

2011 ◽  
Vol 187 (2) ◽  
pp. 835-841 ◽  
Author(s):  
Sherri L. Surman ◽  
Rajeev Rudraraju ◽  
David L. Woodland ◽  
Pradyot Dash ◽  
Paul G. Thomas ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Infection ◽  
Cd8 T Cells ◽  
Lymphoid Tissue ◽  
Respiratory Virus ◽  
Respiratory Virus Infection

scholarly journals Nonspecific Recruitment of Memory CD8+T Cells to the Lung Airways During Respiratory Virus Infections

2003 ◽  
Vol 170 (3) ◽  
pp. 1423-1429 ◽  
Author(s):  
Kenneth H. Ely ◽  
Linda S. Cauley ◽  
Alan D. Roberts ◽  
Jean W. Brennan ◽  
Tres Cookenham ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Respiratory Virus ◽  
Virus Infections ◽  
Memory Cd8 T Cells ◽  
Respiratory Virus Infections ◽  
Lung Airways

scholarly journals Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection

2018 ◽  
Vol 14 (1) ◽  
pp. e1006810 ◽  
Author(s):  
Megan E. Schmidt ◽  
Cory J. Knudson ◽  
Stacey M. Hartwig ◽  
Lecia L. Pewe ◽  
David K. Meyerholz ◽  
...  
Keyword(s):  
T Cells ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Cd8 T Cells ◽  
Memory Cd8 T Cells ◽  
Syncytial Virus
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