scholarly journals Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype

2011 ◽  
Vol 187 (2) ◽  
pp. 842-850 ◽  
Author(s):  
Mireille H. Lahoud ◽  
Fatma Ahmet ◽  
Susie Kitsoulis ◽  
Soo San Wan ◽  
David Vremec ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Follicular Helper

scholarly journals Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 912 ◽  
Author(s):  
Chaitrali Saha ◽  
Mrinmoy Das ◽  
Emmanuel Stephen-Victor ◽  
Alain Friboulet ◽  
Jagadeesh Bayry ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Viscum Album ◽  
Cd4 T Cell ◽  
Differential Effects ◽  
Cell Responses ◽  
Human Dendritic Cells

scholarly journals Helping Themselves: Optimal Virus-Specific CD4 T Cell Responses Require Help via CD4 T Cell Licensing of Dendritic Cells

2014 ◽  
Vol 193 (11) ◽  
pp. 5420-5433 ◽  
Author(s):  
Matthew R. Olson ◽  
Shirley G. K. Seah ◽  
Jolie Cullen ◽  
Marie Greyer ◽  
Kathryn Edenborough ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses

scholarly journals CD4+ T Cell Responses Elicited by Different Subsets of Human Skin Migratory Dendritic Cells

2005 ◽  
Vol 175 (12) ◽  
pp. 7905-7915 ◽  
Author(s):  
Adrian E. Morelli ◽  
J. Peter Rubin ◽  
Geza Erdos ◽  
Olga A. Tkacheva ◽  
Alicia R. Mathers ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Human Skin ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses

scholarly journals SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence

2021 ◽  
Vol 17 (7) ◽  
pp. e1009761
Author(s):  
Sushma Boppana ◽  
Kai Qin ◽  
Jacob K. Files ◽  
Ronnie M. Russell ◽  
Regina Stoltz ◽  
...  
Keyword(s):  
T Cell ◽  
Symptom Onset ◽  
Neutralizing Antibodies ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
T Follicular Helper Cells ◽  
S Protein ◽  
Cell Responses ◽  
Helper Cells ◽  
Follicular Helper

T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate neutralizing antibodies. We longitudinally studied CD4 T-cell responses to the M, N, and S structural proteins of SARS-CoV-2 in 26 convalescent individuals. Within the first two months following symptom onset, a majority of individuals (81%) mounted at least one CD4 T-cell response, and 48% of individuals mounted detectable SARS-CoV-2-specific circulating T follicular helper cells (cTfh, defined as CXCR5+PD1+ CD4 T cells). SARS-CoV-2-specific cTfh responses across all three protein specificities correlated with antibody neutralization with the strongest correlation observed for S protein-specific responses. When examined over time, cTfh responses, particularly to the M protein, increased in convalescence, and robust cTfh responses with magnitudes greater than 5% were detected at the second convalescent visit, a median of 38 days post-symptom onset. CD4 T-cell responses declined but persisted at low magnitudes three months and six months after symptom onset. These data deepen our understanding of antigen-specific cTfh responses in SARS-CoV-2 infection, suggesting that in addition to S protein, M and N protein-specific cTfh may also assist in the development of neutralizing antibodies and that cTfh response formation may be delayed in SARS-CoV-2 infection.

scholarly journals Correction: Saha, C., et al. Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses. Molecules 2016, 21, 912

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3762
Author(s):  
Chaitrali Saha ◽  
Mrinmoy Das ◽  
Emmanuel Stephen-Victor ◽  
Alain Friboulet ◽  
Jagadeesh Bayry ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Viscum Album ◽  
Cd4 T Cell ◽  
Differential Effects ◽  
Cell Responses ◽  
Human Dendritic Cells

The authors wish to make the following corrections to this paper [...]

scholarly journals TLR2 Engagement on Dendritic Cells Promotes High Frequency Effector and Memory CD4 T Cell Responses

2009 ◽  
Vol 183 (12) ◽  
pp. 7832-7841 ◽  
Author(s):  
Smita S. Chandran ◽  
David Verhoeven ◽  
John R. Teijaro ◽  
Matthew J. Fenton ◽  
Donna L. Farber
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
High Frequency ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses

scholarly journals Murine CD4+ T Cell Responses Are Inhibited by Cytotoxic T Cell-Mediated Killing of Dendritic Cells and Are Restored by Antigen Transfer

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e37481 ◽  
Author(s):  
Joel Zhi-Iong Ma ◽  
So Nai Lim ◽  
Jim Shixiang Qin ◽  
Jianping Yang ◽  
Noriyuki Enomoto ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cytotoxic T Cell ◽  
Cell Responses ◽  
Antigen Transfer
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