scholarly journals Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 912 ◽  
Author(s):  
Chaitrali Saha ◽  
Mrinmoy Das ◽  
Emmanuel Stephen-Victor ◽  
Alain Friboulet ◽  
Jagadeesh Bayry ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Viscum Album ◽  
Cd4 T Cell ◽  
Differential Effects ◽  
Cell Responses ◽  
Human Dendritic Cells

scholarly journals Correction: Saha, C., et al. Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4+ T Cell Responses. Molecules 2016, 21, 912

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3762
Author(s):  
Chaitrali Saha ◽  
Mrinmoy Das ◽  
Emmanuel Stephen-Victor ◽  
Alain Friboulet ◽  
Jagadeesh Bayry ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Viscum Album ◽  
Cd4 T Cell ◽  
Differential Effects ◽  
Cell Responses ◽  
Human Dendritic Cells

The authors wish to make the following corrections to this paper [...]

scholarly journals Human Dendritic Cells Infected with the Nonpathogenic Mopeia Virus Induce Stronger T-Cell Responses than Those Infected with Lassa Virus

2011 ◽  
Vol 85 (16) ◽  
pp. 8293-8306 ◽  
Author(s):  
D. Pannetier ◽  
S. Reynard ◽  
M. Russier ◽  
A. Journeaux ◽  
N. Tordo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Lassa Virus ◽  
Cell Responses ◽  
Human Dendritic Cells

Potential Tolerizing Capacity of Human Dendritic Cells Featuring High Levels of Expression and Activity of the Tryptophan Metabolizing Enzyme Indoleamine 2,3 Dioxygenase.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 623-623
Author(s):  
Andreas Heitger ◽  
Birgit Juergens ◽  
Ursula Hainz ◽  
Dietmar Fuchs
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Fraction ◽  
Cell Responses ◽  
Indoleamine 2,3 Dioxygenase ◽  
Ifn Γ ◽  
Human Dendritic Cells ◽  
Expression And Activity

Abstract An enhanced tryptophan metabolism mediated by the enzymatic activity of indoleamine 2,3 dioxygenase (IDO) has recently been demonstrated to profoundly affect T cell responses. By the present study we explored whether human dendritic cells (DCs) displaying high IDO expression and activity, down-regulate allogeneic T cell responses. A comparison of lipopolysaccaride (LPS), interferon-γ (IFN-γ), and CD40L as DC maturation agents showed that most abundant IDO expression and activity in DCs was observed when immature DCs were exposed to a combination of LPS and IFN-γ for 48 hours. This time period of maturation was associated with the development of a mature DC phenotype. In contrast, semi-mature DCs, i.e. DCs matured for 4 hours only, were IDO negative. In co-cultures with allogeneic T cells both types of DCs began to metabolize tryptophan, as determined by decreasing concentrations of tryptophan and increasing concentrations of kynurenines in cell culture supernatants, but mature IDO positive DCs did so at a faster rate (complete consumption of tryptophan within 16 hours of co-culture) than semi-mature DCs. A comparison of the allo-stimulatory capacity of semi-mature IDO negative DCs and mature IDO positive DCs showed that at a high DC/T cell ratio (1:1) IDO positive DCs had a significantly reduced capacity to stimulate allogeneic T cells (median 63% reduction, n=5). The reduction of the allogeneic T cell response induced by IDO positive DCs was reversed upon the addition of the IDO inhibitor methylhydantoin-tryptophan to the co-cultures, suggesting an IDO dependent mechanism. Furthermore, allogeneic T cells exposed to IDO positive DCs had an increased rate of apoptosis in the activated cell fraction and after 8 days of co-culture contained a cell fraction (~30%) displaying a CD4+CD25+highFOXP3+ phenotype. These latter cells, when enriched by fluorescent activated cell sorting (FACS), were able to suppress the proliferative response of naive T cells to anti-CD3 mediated stimulation, which indicates the generation of a regulatory T cell population by IDO positive DCs. Together, these findings suggest that the amount of IDO expression and activity by DCs is one feature to govern the type of response of stimulated T cells. Human DCs can be induced to display high levels of IDO expression and activity and, thereby, acquire the ability to effectivley modulate allogeneic T cell responses towards tolerance by eliminating allo-reactive T cells through apoptosis and augmentation of their regulatory rather than their effector potential. Our current approaches address whether this property can be employed to use DCs for the generation of allo-antigen specific tolerance in the setting of hematopoietic cell transplantation.

scholarly journals Helping Themselves: Optimal Virus-Specific CD4 T Cell Responses Require Help via CD4 T Cell Licensing of Dendritic Cells

2014 ◽  
Vol 193 (11) ◽  
pp. 5420-5433 ◽  
Author(s):  
Matthew R. Olson ◽  
Shirley G. K. Seah ◽  
Jolie Cullen ◽  
Marie Greyer ◽  
Kathryn Edenborough ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses

scholarly journals CD4+ T Cell Responses Elicited by Different Subsets of Human Skin Migratory Dendritic Cells

2005 ◽  
Vol 175 (12) ◽  
pp. 7905-7915 ◽  
Author(s):  
Adrian E. Morelli ◽  
J. Peter Rubin ◽  
Geza Erdos ◽  
Olga A. Tkacheva ◽  
Alicia R. Mathers ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Human Skin ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses

scholarly journals TLR2 Engagement on Dendritic Cells Promotes High Frequency Effector and Memory CD4 T Cell Responses

2009 ◽  
Vol 183 (12) ◽  
pp. 7832-7841 ◽  
Author(s):  
Smita S. Chandran ◽  
David Verhoeven ◽  
John R. Teijaro ◽  
Matthew J. Fenton ◽  
Donna L. Farber
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
High Frequency ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Cell Responses
Sign in / Sign up

Export Citation Format

Share Document