scholarly journals The Novel Role of SERPINB9 in Cytotoxic Protection of Human Mesenchymal Stem Cells

2011 ◽  
Vol 187 (5) ◽  
pp. 2252-2260 ◽  
Author(s):  
Najib El Haddad ◽  
Robert Moore ◽  
Dean Heathcote ◽  
Marwan Mounayar ◽  
Jamil Azzi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
The Novel

Magnetic field assisted stem cell differentiation – role of substrate magnetization in osteogenesis

2015 ◽  
Vol 3 (16) ◽  
pp. 3150-3168 ◽  
Author(s):  
Sunil Kumar Boda ◽  
Greeshma Thrivikraman ◽  
Bikramjit Basu
Keyword(s):  
Magnetic Field ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Bone Tissue Engineering ◽  
Human Mesenchymal Stem Cells ◽  
Stem Cell Differentiation

Substrate magnetization as a tool for modulating the osteogenesis of human mesenchymal stem cells for bone tissue engineering applications.

scholarly journals The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration

Oncotarget ◽  
2017 ◽  
Vol 8 (13) ◽  
pp. 21031-21043 ◽  
Author(s):  
Deting Xue ◽  
Erman Chen ◽  
Wei Zhang ◽  
Xiang Gao ◽  
Shengdong Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Human Mesenchymal Stem Cells

Su1793 The Protective Role of Human Mesenchymal Stem Cells in Acute Pancreatitis in Mice

2013 ◽  
Vol 144 (5) ◽  
pp. S-478
Author(s):  
Michael Gonzales ◽  
Xuxia Gao ◽  
Yanna Cao ◽  
Hasen Xue ◽  
Judith Aronson ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Pancreatitis ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Protective Role

scholarly journals Role of Wnt-5a in the Determination of Human Mesenchymal Stem Cells into Preadipocytes

2009 ◽  
Vol 285 (9) ◽  
pp. 6170-6178 ◽  
Author(s):  
Roman Bilkovski ◽  
Dominik M. Schulte ◽  
Frank Oberhauser ◽  
Matthias Gomolka ◽  
Michael Udelhoven ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells

2007 ◽  
Vol 310 (1-2) ◽  
pp. 11-18 ◽  
Author(s):  
Weihua Yu ◽  
Zhenguang Chen ◽  
Jinli Zhang ◽  
Lirong Zhang ◽  
Hui Ke ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Critical Role ◽  
Human Mesenchymal Stem Cells ◽  
Kinase Cascade ◽  
Phosphoinositide 3 Kinase

scholarly journals Role of Slug transcription factor in human mesenchymal stem cells

2012 ◽  
Vol 16 (4) ◽  
pp. 740-751 ◽  
Author(s):  
Elena Torreggiani ◽  
Gina Lisignoli ◽  
Cristina Manferdini ◽  
Elisabetta Lambertini ◽  
Letizia Penolazzi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Transcription Factor ◽  
Human Mesenchymal Stem Cells

scholarly journals The p53/miR-145a Axis Promotes Cellular Senescence and Inhibits Osteogenic Differentiation by Targeting Cbfb in Mesenchymal Stem Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Chao Xia ◽  
Tianyuan Jiang ◽  
Yonghui Wang ◽  
Xiaoting Chen ◽  
Yan Hu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Cellular Senescence ◽  
Negative Regulator ◽  
The Novel ◽  
Binding Factor ◽  
Marrow Mesenchymal Stem Cells ◽  
Core Binding Factor Beta

The osteogenic differentiation capacity of senescent bone marrow mesenchymal stem cells (MSCs) is reduced. p53 not only regulates cellular senescence but also functions as a negative regulator in bone formation. However, the role of p53 in MSCs senescence and differentiation has not been extensively explored. In the present study, we investigated the molecular mechanism of p53 in MSCs senescence and osteogenic differentiation. We found that p53 was upregulated during cellular senescence and osteogenic differentiation of MSCs respectively induced by H2O2 and BMP9. Similarly, the expression of p53-induced miR-145a was increased significantly. Furthermore, Overexpression of miR-145a in MSCs promoted cellular senescence and inhibited osteogenic differentiation. Then, we identified that p53-induced miR-145a inhibited osteogenic differentiation by targeting core binding factor beta (Cbfb), and the restoration of Cbfb expression rescued the inhibitory effects of miRNA-145a. In summary, our results indicate that p53/miR-145a axis exert its functions both in promoting senescence and inhibiting osteogenesis of MSCs, and the novel p53/miR-145a/Cbfb axis in osteogenic differentiation of MSCs may represent new targets in the treatment of osteoporosis.

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