scholarly journals IL-2 Contributes to Maintaining a Balance between CD4+Foxp3+ Regulatory T Cells and Effector CD4+ T Cells Required for Immune Control of Blood-Stage Malaria Infection

2011 ◽  
Vol 186 (8) ◽  
pp. 4862-4871 ◽  
Author(s):  
Floriana Berretta ◽  
Jessica St-Pierre ◽  
Ciriaco A. Piccirillo ◽  
Mary M. Stevenson
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cd4 T Cells ◽  
Malaria Infection ◽  
Blood Stage ◽  
Immune Control ◽  
Blood Stage Malaria

scholarly journals Pullulan-Coated Iron Oxide Nanoparticles for Blood-Stage Malaria Vaccine Delivery

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 651
Author(s):  
Liam Powles ◽  
Kirsty L. Wilson ◽  
Sue D. Xiang ◽  
Ross L. Coppel ◽  
Charles Ma ◽  
...  
Keyword(s):  
T Cells ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cd4 T Cells ◽  
Size Range ◽  
Blood Stage ◽  
Th2 Cells ◽  
Oxide Nanoparticles ◽  
T Helper ◽  
Blood Stage Malaria

Vaccines against blood-stage malaria often aim to induce antibodies to neutralize parasite entry into red blood cells, interferon gamma (IFNγ) produced by T helper 1 (Th1) CD4+ T cells or interleukin 4 (IL-4) produced by T helper 2 (Th2) cells to provide B cell help. One vaccine delivery method for suitable putative malaria protein antigens is the use of nanoparticles as vaccine carriers. It has been previously shown that antigen conjugated to inorganic nanoparticles in the viral-particle size range (~40–60 nm) can induce protective antibodies and T cells against malaria antigens in a rodent malaria challenge model. Herein, it is shown that biodegradable pullulan-coated iron oxide nanoparticles (pIONPs) can be synthesized in this same size range. The pIONPs are non-toxic and do not induce conventional pro-inflammatory cytokines in vitro and in vivo. We show that murine blood-stage antigen MSP4/5 from Plasmodium yoelii could be chemically conjugated to pIONPs and the use of these conjugates as immunogens led to the induction of both specific antibodies and IFNγ CD4+ T cells reactive to MSP4/5 in mice, comparable to responses to MSP4/5 mixed with classical adjuvants (e.g., CpG or Alum) that preferentially induce Th1 or Th2 cells individually. These results suggest that biodegradable pIONPs warrant further exploration as carriers for developing blood-stage malaria vaccines.

scholarly journals Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4

2017 ◽  
Vol 23 (10) ◽  
pp. 1220-1225 ◽  
Author(s):  
Samarchith P Kurup ◽  
Nyamekye Obeng-Adjei ◽  
Scott M Anthony ◽  
Boubacar Traore ◽  
Ogobara K Doumbo ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Blood Stage ◽  
Blood Stage Malaria

scholarly journals Parasite-Specific CD4+IFN-γ+IL-10+T Cells Distribute within Both Lymphoid and Nonlymphoid Compartments and Are Controlled Systemically by Interleukin-27 and ICOS during Blood-Stage Malaria Infection

2015 ◽  
Vol 84 (1) ◽  
pp. 34-46 ◽  
Author(s):  
Ana Villegas-Mendez ◽  
Tovah N. Shaw ◽  
Colette A. Inkson ◽  
Patrick Strangward ◽  
J. Brian de Souza ◽  
...  
Keyword(s):  
T Cells ◽  
Malaria Infection ◽  
Fluorescent Protein ◽  
Yellow Fluorescent Protein ◽  
Interleukin 10 ◽  
Plasmodium Yoelii ◽  
Blood Stage ◽  
Content Type ◽  
Ifn Γ ◽  
Blood Stage Malaria

Immune-mediated pathology in interleukin-10 (IL-10)-deficient mice during blood-stage malaria infection typically manifests in nonlymphoid organs, such as the liver and lung. Thus, it is critical to define the cellular sources of IL-10 in these sensitive nonlymphoid compartments during infection. Moreover, it is important to determine if IL-10 production is controlled through conserved or disparate molecular programs in distinct anatomical locations during malaria infection, as this may enable spatiotemporal tuning of the regulatory immune response. In this study, using dual gamma interferon (IFN-γ)–yellow fluorescent protein (YFP) and IL-10–green fluorescent protein (GFP) reporter mice, we show that CD4+YFP+T cells are the major source of IL-10 in both lymphoid and nonlymphoid compartments throughout the course of blood-stagePlasmodium yoeliiinfection. Mature splenic CD4+YFP+GFP+T cells, which preferentially expressed high levels of CCR5, were capable of migrating to and seeding the nonlymphoid tissues, indicating that the systemically distributed host-protective cells have a common developmental history. Despite exhibiting comparable phenotypes, CD4+YFP+GFP+T cells from the liver and lung produced significantly larger quantities of IL-10 than their splenic counterparts, showing that the CD4+YFP+GFP+T cells exert graded functions in distinct tissue locations during infection. Unexpectedly, given the unique environmental conditions within discrete nonlymphoid and lymphoid organs, we show that IL-10 production by CD4+YFP+T cells is controlled systemically during malaria infection through IL-27 receptor signaling that is supported after CD4+T cell priming by ICOS signaling. The results in this study substantially improve our understanding of the systemic IL-10 response to malaria infection, particularly within sensitive nonlymphoid organs.

Suppression of Pathogenic Autoreactive CD4+ T Cells by CD137-mediated Expansion of CD4+CD25+ Regulatory T Cells in Graves' Disease

2007 ◽  
Vol 22 (5) ◽  
pp. 332
Author(s):  
Eun Sook Kim ◽  
Hyo Won Jung ◽  
Jung Il Choi ◽  
Il Seung Nam-Goong ◽  
Soon Hyung Hong ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cd4 T Cells ◽  
Graves Disease
Sign in / Sign up

Export Citation Format

Share Document