scholarly journals Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4

2017 ◽  
Vol 23 (10) ◽  
pp. 1220-1225 ◽  
Author(s):  
Samarchith P Kurup ◽  
Nyamekye Obeng-Adjei ◽  
Scott M Anthony ◽  
Boubacar Traore ◽  
Ogobara K Doumbo ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Blood Stage ◽  
Blood Stage Malaria

scholarly journals Mice lacking Programmed cell death-1 show a role for CD8+ T cells in long-term immunity against blood-stage malaria

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Joshua M. Horne-Debets ◽  
Deshapriya S. Karunarathne ◽  
Rebecca J. Faleiro ◽  
Chek Meng Poh ◽  
Laurent Renia ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Cd8 T Cells ◽  
Blood Stage ◽  
Programmed Cell Death 1 ◽  
Blood Stage Malaria

Anti-CD20 therapy corrects a CD8 regulatory T cell deficit in multiple sclerosis

2021 ◽  
pp. 135245852110033
Author(s):  
Quentin Howlett-Prieto ◽  
Xuan Feng ◽  
John F Kramer ◽  
Kevin J Kramer ◽  
Timothy W Houston ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
B Cell ◽  
Regulatory T Cell ◽  
Healthy Controls ◽  
Regulatory Cells ◽  
Long Term Treatment ◽  
Anti Cd20

Objective: To determine the effect of long-term anti-CD20 B-cell-depleting treatment on regulatory T cell immune subsets that are subnormal in untreated MS patients. Methods: 30 clinically stable MS patients, before and over 38 months of ocrelizumab treatment, were compared to 13 healthy controls, 29 therapy-naïve MS, 9 interferon-β-treated MS, 3 rituximab-treated MS, and 3 rituximab-treated patients with other autoimmune inflammatory diseases. CD8, CD28, CD4, and FOXP3 expression in peripheral blood mononuclear cells was quantitated with flow cytometry. Results: CD8+ CD28− regulatory cells rose from one-third of healthy control levels before ocrelizumab treatment (2.68% vs 7.98%), normalized by 12 months (13.5%), and rose to 2.4-fold above healthy controls after 18 months of ocrelizumab therapy (19.0%). CD4+ FOXP3+ regulatory cells were lower in MS than in healthy controls (7.98%) and showed slight long-term decreases with ocrelizumab. CD8+ CD28− and CD4+ FOXP3+ regulatory T cell percentages in IFN-β-treated MS patients were between those of untreated MS and healthy controls. Interpretation: Long-term treatment with ocrelizumab markedly enriches CD8+ CD28− regulatory T cells and corrects the low levels seen in MS before treatment, while slightly decreasing CD4+ FOXP3+ regulatory T cells. Homeostatic enrichment of regulatory CD8 T cells provides a mechanism, in addition to B cell depletion, for the benefits of anti-CD20 treatment in MS.

Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis

2010 ◽  
Vol 38 (8) ◽  
pp. 1718-1725 ◽  
Author(s):  
Daniele C. Nascimento ◽  
José C. Alves-Filho ◽  
Fabiane Sônego ◽  
Sandra Y. Fukada ◽  
Marcelo S. Pereira ◽  
...  
Keyword(s):  
T Cells ◽  
Severe Sepsis ◽  
Regulatory T Cells ◽  
Immune Dysfunction

scholarly journals Evidence That FoxP3+ Regulatory T Cells May Play a Role in Promoting Long-Term Acceptance of Composite Tissue Allotransplants

2011 ◽  
Vol 91 (8) ◽  
pp. 908-915 ◽  
Author(s):  
Larry D. Bozulic ◽  
Yujie Wen ◽  
Hong Xu ◽  
Suzanne T. Ildstad
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Composite Tissue

CD25 regulatory T cells determine secondary but not primary remission in EAE: Impact on long-term disease progression☆

2006 ◽  
Vol 172 (1-2) ◽  
pp. 73-84 ◽  
Author(s):  
D GARTNER ◽  
H HOFF ◽  
U GIMSA ◽  
G BURMESTER ◽  
M BRUNNERWEINZIERL
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Disease Progression

scholarly journals Roles of IFN-γ and γδ T Cells in Protective Immunity Against Blood-Stage Malaria

2013 ◽  
Vol 4 ◽  
Author(s):  
Shin-Ichi Inoue ◽  
Mamoru Niikura ◽  
Shoichiro Mineo ◽  
Fumie Kobayashi
Keyword(s):  
T Cells ◽  
Protective Immunity ◽  
Γδ T Cells ◽  
Blood Stage ◽  
Ifn Γ ◽  
Blood Stage Malaria
Sign in / Sign up

Export Citation Format

Share Document