scholarly journals Group V Secretory Phospholipase A2 Reveals Its Role in House Dust Mite-Induced Allergic Pulmonary Inflammation by Regulation of Dendritic Cell Function

2010 ◽  
Vol 185 (7) ◽  
pp. 4430-4438 ◽  
Author(s):  
Giorgio Giannattasio ◽  
Daisuke Fujioka ◽  
Wei Xing ◽  
Howard R. Katz ◽  
Joshua A. Boyce ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Phospholipase A2 ◽  
House Dust ◽  
House Dust Mite ◽  
Cell Function ◽  
Pulmonary Inflammation ◽  
Secretory Phospholipase A2 ◽  
Dendritic Cell Function ◽  
Group V ◽  
Dust Mite

Group V Secretory PLA2 Alternative Activation of Macrophages Contributes to Pulmonary Inflammation Induced by House Dust Mite

2011 ◽  
Vol 127 (2) ◽  
pp. AB270-AB270
Author(s):  
B. Balestrieri ◽  
G. Giannattasio ◽  
D. Fujioka ◽  
S. Ota ◽  
H. Katz ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Pulmonary Inflammation ◽  
Alternative Activation ◽  
Group V ◽  
Dust Mite

scholarly journals Effect of Low-Level Laser Therapy (LLLT) in Pulmonary Inflammation in Asthma Induced by House Dust Mite (HDM): Dosimetry Study

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Nicole Cristine Rigonato-Oliveira ◽  
Auriléia Aparecida de Brito ◽  
Luana Beatriz Vitoretti ◽  
Gabriel de Cunha Moraes ◽  
Tawany Gonçalves ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Laser Therapy ◽  
House Dust ◽  
House Dust Mite ◽  
Structural Parameters ◽  
Pulmonary Inflammation ◽  
Low Level Laser Therapy ◽  
Low Level Laser ◽  
Level Laser ◽  
Dust Mite

Asthma is characterized by chronic inflammation in the airways. Several models have been proposed for the discovery of new therapies. Low-Level Laser Therapy (LLLT) is relatively new and effective, very low cost, with no side effects. However, there is still no consensus on the optimal dose to be used. In this sense, the objective of the present study was to evaluate the best dose in an experimental model of asthma induced by House Dust Mite (HDM). Balb/c mice received administration of 100 ug/animal HDM and LLLT applications (diode laser: 660 nm, 100 mW and four different energies 1J, 3J, 5J, and 7.5J) for 16 days. After 24 hours, we studied inflammatory, functional, and structural parameters. The results showed that LBI was able to modulate the pulmonary inflammation observed by reducing the number of cells in Bronchoalveolar Lavage Fluid (BALF) as well as reducing the percentage of neutrophils, eosinophils and T lymphocytes. On the other hand, LLLT increased the level of IL-10 and reduced levels of IL-4, IL-5 and IL-13 in BALF. LLLT was able to reduce the production of mucus, peribronchial eosinophils, collagen deposition, bronchoconstriction index, and bronchial and muscular thickening in the airways. We concluded that the use of LLLT in the treatment of chronic inflammation of the airways attenuated the inflammatory process and functional and structural parameters. We emphasize, in general, that the 1J and 3J laser presented better results. Thus, photobiomodulation may be considered a promising tool for the treatment of chronic pulmonary allergic inflammation observed in asthma.

scholarly journals Characteristics of Allergic Pulmonary Inflammation in CXCR3Knockout Mice Sensitized and Challenged with House Dust Mite Protein

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0162905 ◽  
Author(s):  
Zhongjuan Liu ◽  
Huaxia Chen ◽  
Xiaolan Chen ◽  
Jinming Gao ◽  
Zijian Guo
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Pulmonary Inflammation ◽  
Dust Mite

scholarly journals PARP Inhibition Blocks Asthma Manifestation in a Chronic House Dust Mite (HDM) Asthma Model and Differentially Modulates Human CD4 + T cell Function

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Mohamed Ghonim ◽  
Amarjit Naura ◽  
Kusma Pyakurel ◽  
Matthew Lammi ◽  
Paulo Rodriguez ◽  
...  
Keyword(s):  
T Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Cell Function ◽  
Cd4 T Cell ◽  
Parp Inhibition ◽  
Asthma Model ◽  
T Cell Function ◽  
Dust Mite

Absence of Glutathione S-Transferase Pi Dampens House Dust Mite-Induced Pulmonary Inflammation But Not Airway Hyperresponsiveness

2015 ◽  
Vol 87 ◽  
pp. S140
Author(s):  
Xi Qian ◽  
Robert W. Schneider ◽  
Karolyn G. Lahue ◽  
Lennart K.A. Lundblad ◽  
Nirav Daphtary ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Airway Hyperresponsiveness ◽  
Pulmonary Inflammation ◽  
Glutathione S Transferase ◽  
Dust Mite
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