scholarly journals The TLR7 Agonist R848 Alleviates Allergic Inflammation by Targeting Invariant NKT Cells To Produce IFN-γ

2010 ◽  
Vol 186 (1) ◽  
pp. 284-290 ◽  
Author(s):  
Françoise Grela ◽  
Aude Aumeunier ◽  
Emilie Bardel ◽  
Linh Pham Van ◽  
Elvire Bourgeois ◽  
...  
Keyword(s):  
Allergic Inflammation ◽  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Tlr7 Agonist ◽  
Ifn Γ

scholarly journals Activation of Invariant NKT Cells Ameliorates Experimental Ocular Autoimmunity by A Mechanism Involving Innate IFN-γ Production and Dampening of the Adaptive Th1 and Th17 Responses

2008 ◽  
Vol 181 (7) ◽  
pp. 4791-4797 ◽  
Author(s):  
Rafael S. Grajewski ◽  
Anna M. Hansen ◽  
Rajeev K. Agarwal ◽  
Mitchell Kronenberg ◽  
Stephane Sidobre ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Ifn Γ

Activation of invariant NKT cells by αGalCer administration protects mice from MOG35–55-induced EAE: critical roles for administration route and IFN-γ

2003 ◽  
Vol 33 (7) ◽  
pp. 1830-1838 ◽  
Author(s):  
Roberto Furlan ◽  
Alessandra Bergami ◽  
Daniela Cantarella ◽  
Elena Brambilla ◽  
Masaro Taniguchi ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Administration Route ◽  
Invariant Nkt Cells ◽  
Ifn Γ

scholarly journals IFN-γ-Producing Human Invariant NKT Cells Promote Tumor-Associated Antigen-Specific Cytotoxic T Cell Responses

2008 ◽  
Vol 181 (4) ◽  
pp. 2446-2454 ◽  
Author(s):  
María Moreno ◽  
Johan W. Molling ◽  
Silvia von Mensdorff-Pouilly ◽  
René H. M. Verheijen ◽  
Erik Hooijberg ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Nkt Cells ◽  
Cytotoxic T Cell ◽  
Invariant Nkt Cells ◽  
Cell Responses ◽  
Tumor Associated Antigen ◽  
Ifn Γ ◽  
Cytotoxic T Cell Responses

scholarly journals Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-γ Production

2009 ◽  
Vol 184 (3) ◽  
pp. 1242-1250 ◽  
Author(s):  
Stephen R. Mattarollo ◽  
Azad Rahimpour ◽  
Allison Choyce ◽  
Dale I. Godfrey ◽  
Graham R. Leggatt ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Ifn Γ

scholarly journals Comment on “Invariant NKT Cells in Hyperplastic Skin Induced a Local Immune Suppressive Environment by IFN-γ Production”

2012 ◽  
Vol 188 (3) ◽  
pp. 931.1-931
Author(s):  
Ting Hu ◽  
Hongmei Zhu ◽  
He Wang ◽  
Shanling Liu
Keyword(s):  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Ifn Γ

scholarly journals Invariant NKT Cells Are Essential for the Regulation of Hepatic CXCL10 Gene Expression during Leishmania donovani Infection

2005 ◽  
Vol 73 (11) ◽  
pp. 7541-7547 ◽  
Author(s):  
Mattias Svensson ◽  
Soombul Zubairi ◽  
Asher Maroof ◽  
Fatima Kazi ◽  
Masaru Taniguchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Nk Cells ◽  
Leishmania Donovani ◽  
Cell Receptor ◽  
Nkt Cells ◽  
Mrna Accumulation ◽  
Invariant Nkt Cells ◽  
Early Expression ◽  
Ifn Γ

ABSTRACT Gamma interferon (IFN-γ)-regulated chemokines of the CXC family have been implicated as key regulators of a variety of T-cell-dependent inflammatory processes. However, the cellular source(s) of IFN-γ that regulates their early expression has rarely been defined. Here, we have directly addressed this question in mice after Leishmania donovani infection. Comparison of CXCL10 mRNA accumulation in normal and IFN-γ-deficient mice confirmed an absolute requirement for IFN-γ for sustained (24 h) expression of CXCL10 mRNA accumulation in this model. In normal mice, IFN-γ was produced by both CD3int NK1.1+ NKT cells and CD3− NK1.1+ NK cells, as detected by intracellular flow cytometry. Strikingly, B6.Jα281−/− mice lacking NKT cells that express the invariant Vα14Jα18 T-cell-receptor α chain, although retaining a significant population of IFN-γ-producing NK cells and NKT cells, were unable to sustain CXCL10 mRNA accumulation. These data indicate that invariant NKT cells are indispensable for the regulation of hepatic CXCL10 gene expression during L. donovani infection.

scholarly journals Sodium chloride inhibits IFN-γ, but not IL-4, production by invariant NKT cells

2017 ◽  
Vol 103 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Dongjin Jeong ◽  
Hye Young Kim ◽  
Doo Hyun Chung
Keyword(s):  
Sodium Chloride ◽  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Ifn Γ
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