scholarly journals T Cell Ig Domain and Mucin Domain 1 Engagement on Invariant NKT Cells in the Presence of TCR Stimulation Enhances IL-4 Production but Inhibits IFN-γ Production

2010 ◽  
Vol 184 (8) ◽  
pp. 4095-4106 ◽  
Author(s):  
Hye Sung Kim ◽  
Hyun Soo Kim ◽  
Chang Woo Lee ◽  
Doo Hyun Chung
Keyword(s):  
T Cell ◽  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Ifn Γ ◽  
Ig Domain

scholarly journals IFN-γ-Producing Human Invariant NKT Cells Promote Tumor-Associated Antigen-Specific Cytotoxic T Cell Responses

2008 ◽  
Vol 181 (4) ◽  
pp. 2446-2454 ◽  
Author(s):  
María Moreno ◽  
Johan W. Molling ◽  
Silvia von Mensdorff-Pouilly ◽  
René H. M. Verheijen ◽  
Erik Hooijberg ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Nkt Cells ◽  
Cytotoxic T Cell ◽  
Invariant Nkt Cells ◽  
Cell Responses ◽  
Tumor Associated Antigen ◽  
Ifn Γ ◽  
Cytotoxic T Cell Responses

scholarly journals Invariant NKT Cells Are Essential for the Regulation of Hepatic CXCL10 Gene Expression during Leishmania donovani Infection

2005 ◽  
Vol 73 (11) ◽  
pp. 7541-7547 ◽  
Author(s):  
Mattias Svensson ◽  
Soombul Zubairi ◽  
Asher Maroof ◽  
Fatima Kazi ◽  
Masaru Taniguchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Nk Cells ◽  
Leishmania Donovani ◽  
Cell Receptor ◽  
Nkt Cells ◽  
Mrna Accumulation ◽  
Invariant Nkt Cells ◽  
Early Expression ◽  
Ifn Γ

ABSTRACT Gamma interferon (IFN-γ)-regulated chemokines of the CXC family have been implicated as key regulators of a variety of T-cell-dependent inflammatory processes. However, the cellular source(s) of IFN-γ that regulates their early expression has rarely been defined. Here, we have directly addressed this question in mice after Leishmania donovani infection. Comparison of CXCL10 mRNA accumulation in normal and IFN-γ-deficient mice confirmed an absolute requirement for IFN-γ for sustained (24 h) expression of CXCL10 mRNA accumulation in this model. In normal mice, IFN-γ was produced by both CD3int NK1.1+ NKT cells and CD3− NK1.1+ NK cells, as detected by intracellular flow cytometry. Strikingly, B6.Jα281−/− mice lacking NKT cells that express the invariant Vα14Jα18 T-cell-receptor α chain, although retaining a significant population of IFN-γ-producing NK cells and NKT cells, were unable to sustain CXCL10 mRNA accumulation. These data indicate that invariant NKT cells are indispensable for the regulation of hepatic CXCL10 gene expression during L. donovani infection.

scholarly journals Activation of Invariant NKT Cells Ameliorates Experimental Ocular Autoimmunity by A Mechanism Involving Innate IFN-γ Production and Dampening of the Adaptive Th1 and Th17 Responses

2008 ◽  
Vol 181 (7) ◽  
pp. 4791-4797 ◽  
Author(s):  
Rafael S. Grajewski ◽  
Anna M. Hansen ◽  
Rajeev K. Agarwal ◽  
Mitchell Kronenberg ◽  
Stephane Sidobre ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Ifn Γ

Activation of invariant NKT cells by αGalCer administration protects mice from MOG35–55-induced EAE: critical roles for administration route and IFN-γ

2003 ◽  
Vol 33 (7) ◽  
pp. 1830-1838 ◽  
Author(s):  
Roberto Furlan ◽  
Alessandra Bergami ◽  
Daniela Cantarella ◽  
Elena Brambilla ◽  
Masaro Taniguchi ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Administration Route ◽  
Invariant Nkt Cells ◽  
Ifn Γ

scholarly journals The Pro-Th1 Cytokine IL-12 Enhances IL-4 Production by Invariant NKT Cells: Relevance for T Cell-Mediated Hepatitis

2007 ◽  
Vol 178 (9) ◽  
pp. 5435-5442 ◽  
Author(s):  
Ren Zhu ◽  
Séverine Diem ◽  
Luiza M. Araujo ◽  
Aude Aumeunier ◽  
Jordan Denizeau ◽  
...  
Keyword(s):  
T Cell ◽  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Th1 Cytokine

scholarly journals Natural killer T cells in lipoprotein metabolism and atherosclerosis

2011 ◽  
Vol 106 (11) ◽  
pp. 814-819 ◽  
Author(s):  
Godfrey Getz ◽  
Paul VanderLaan ◽  
Catherine Reardon
Keyword(s):  
T Cells ◽  
T Cell ◽  
Natural Killer ◽  
Cell Receptor ◽  
Nkt Cells ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Invariant Nkt Cells ◽  
Adaptive Immune ◽  
Natural Killer T

SummaryCells of both the innate and adaptive immune system participate in the development of atherosclerosis, a chronic inflammatory disorder of medium and large arteries. Natural killer T (NKT) cells express surface markers characteristic of natural killer cells and conventional T cells and bridge the innate and adaptive immune systems. The development and activation of NKT cells is dependent upon CD1d, a MHC-class I-type molecule that presents lipids, especially glycolipids to the T cell receptors on NKT cells. There are two classes of NKT cells; invariant NKT cells that express a semi-invariant T cell receptor and variant NKT cells. This review summarises studies in murine models in which the effect of the activation, overexpression or deletion of NKT cells or only invariant NKT cells on atherosclerosis has been examined.

scholarly journals Differential Regulation of Cytokine Production by CD1d-Restricted NKT Cells in Response to Superantigen Staphylococcal Enterotoxin B Exposure

2006 ◽  
Vol 74 (1) ◽  
pp. 282-288 ◽  
Author(s):  
Melanie J. Ragin ◽  
Nisebita Sahu ◽  
Avery August
Keyword(s):  
T Cells ◽  
T Cell ◽  
Interleukin 2 ◽  
Nkt Cells ◽  
Staphylococcal Enterotoxin ◽  
Cytokine Secretion ◽  
Staphylococcal Enterotoxin B ◽  
Tnf Α ◽  
Ifn Γ ◽  
Enterotoxin B

ABSTRACT NKT cells are a heterogeneous population characterized by the ability to rapidly produce cytokines, such as interleukin 2 (IL-2), IL-4, and gamma interferon (IFN-γ) in response to infections by viruses, bacteria, and parasites. The bacterial superantigen staphylococcal enterotoxin B (SEB) interacts with T cells bearing the Vβ3, -7, or -8 T-cell receptors, inducing their expansion and cytokine secretion, leading to death in some cases due to cytokine poisoning. The majority of NKT cells bear the Vβ7 or -8 T-cell receptor, suggesting that they may play a role in regulating this response. Using mice lacking NKT cells (CD1d−/− and Jα18−/− mice), we set out to identify the role of these cells in T-cell expansion, cytokine secretion, and toxicity induced by exposure to SEB. We find that Vβ8+ CD4+ T-cell populations similarly expand in wild-type (WT) and NKT cell-null mice and that NKT cells did not regulate the secretion of IL-2. By contrast, these cells positively regulated the secretion of IL-4 and IFN-γ production and negatively regulated the secretion of tumor necrosis factor alpha (TNF-α). However, this negative regulation of TNF-α secretion by NKT cells provides only a minor protective effect on SEB-mediated shock in WT mice compared to mice lacking NKT cells. These data suggest that NKT cells may regulate the nature of the cytokine response to exposure to the superantigen SEB and may act as regulatory T cells during exposure to this superantigen.

scholarly journals Invariant NKT Cells in Hyperplastic Skin Induce a Local Immune Suppressive Environment by IFN-γ Production

2009 ◽  
Vol 184 (3) ◽  
pp. 1242-1250 ◽  
Author(s):  
Stephen R. Mattarollo ◽  
Azad Rahimpour ◽  
Allison Choyce ◽  
Dale I. Godfrey ◽  
Graham R. Leggatt ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Ifn Γ
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