scholarly journals Autoimmunity during Thymectomy-Induced Lymphopenia: Role of Thymus Ablation and Initial Effector T Cell Activation Timing in Nonobese Diabetic Mice

2009 ◽  
Vol 183 (8) ◽  
pp. 4913-4920 ◽  
Author(s):  
Marie-Claude Gagnerault ◽  
Olivia Lanvin ◽  
Virginie Pasquier ◽  
Corinne Garcia ◽  
Diane Damotte ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Diabetic Mice ◽  
Effector T Cell ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Correction: Autoimmunity during Thymectomy-Induced Lymphopenia: Role of Thymus Ablation and Initial Effector T Cell Activation Timing in Nonobese Diabetic Mice

2010 ◽  
Vol 185 (5) ◽  
pp. 3111-3111
Author(s):  
Marie-Claude Gagnerault ◽  
Olivia Lanvin ◽  
Virginie Pasquier ◽  
Corinne Garcia ◽  
Diane Damotte ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Diabetic Mice ◽  
Effector T Cell ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Correction: Levels of Adenosine Deaminase on Dendritic Cells Promote Autoreactive T Cell Activation and Diabetes in Nonobese Diabetic Mice

2011 ◽  
Vol 187 (4) ◽  
pp. 2031-2031
Author(s):  
Faranak Ghaemi Oskouie ◽  
Afshin Shameli ◽  
Ailian Yang ◽  
Melanie D. Desrosiers ◽  
Ashley D. Mucsi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Adenosine Deaminase ◽  
T Cell Activation ◽  
Cell Activation ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Autoreactive T Cell ◽  
Nonobese Diabetic Mice

scholarly journals Differential Contributions of APC Subsets to T Cell Activation in Nonobese Diabetic Mice

2008 ◽  
Vol 180 (8) ◽  
pp. 5235-5249 ◽  
Author(s):  
Annette M. Marleau ◽  
Kelly L. Summers ◽  
Bhagirath Singh
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals High Levels of Adenosine Deaminase on Dendritic Cells Promote Autoreactive T Cell Activation and Diabetes in Nonobese Diabetic Mice

2011 ◽  
Vol 186 (12) ◽  
pp. 6798-6806 ◽  
Author(s):  
Faranak Ghaemi Oskouie ◽  
Afshin Shameli ◽  
Ailian Yang ◽  
Melanie D. Desrosiers ◽  
Ashley D. Mucsi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Adenosine Deaminase ◽  
T Cell Activation ◽  
Cell Activation ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Autoreactive T Cell ◽  
Nonobese Diabetic Mice

Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis

2018 ◽  
Vol 62 (3) ◽  
pp. 398-406 ◽  
Author(s):  
Atsunobu Takeda ◽  
Hisakata Yamada ◽  
Eiichi Hasegawa ◽  
Mitsuru Arima ◽  
Shoji Notomi ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Crucial Role ◽  
P2x7 Receptor ◽  
Cell Activation ◽  
Experimental Autoimmune Uveitis ◽  
Autoimmune Uveitis ◽  
Effector T Cell ◽  
Experimental Autoimmune

scholarly journals Development of Type 1 Diabetes Mellitus in Nonobese Diabetic Mice Follows Changes in Thymocyte and Peripheral T Lymphocyte Transcriptional Activity

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Thais A. Fornari ◽  
Paula B. Donate ◽  
Claudia Macedo ◽  
Elza T. Sakamoto-Hojo ◽  
Eduardo A. Donadi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Activation ◽  
Transcriptional Activity ◽  
Cell Activation ◽  
Autoimmune Diabetes ◽  
Immune Reactivity ◽  
Diabetic Mice ◽  
Nonobese Diabetic

As early as one month of age, nonobese diabetic (NOD) mice feature pancreatic infiltration of autoreactive T lymphocytes, which destruct insulin-producing beta cells, producing autoimmune diabetes mellitus (T1D) within eight months. Thus, we hypothesized that during the development of T1D, the transcriptional modulation of immune reactivity genes may occur as thymocytes mature into peripheral T lymphocytes. The transcriptome of thymocytes and peripheral CD3+T lymphocytes from prediabetic or diabetic mice analyzed through microarray hybridizations identified 2,771 differentially expressed genes. Hierarchical clustering grouped mice according to age/T1D onset and genes according to their transcription profiling. The transcriptional activity of thymocytes developing into peripheral T lymphocytes revealed sequential participation of genes involved with CD4+/CD8+T-cell differentiation (Themis), tolerance induction by Tregs (Foxp3), and apoptosis (Fasl) soon after T-cell activation (IL4), while the emergence of T1D coincided with the expression of cytotoxicity (Crtam) and inflammatory response genes (Tlr) by peripheral T lymphocytes.

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