scholarly journals α2-Macroglobulin Capture Allows Detection of Mast Cell Chymase in Serum and Creates a Reservoir of Angiotensin II-Generating Activity

2009 ◽  
Vol 182 (9) ◽  
pp. 5770-5777 ◽  
Author(s):  
Wilfred W. Raymond ◽  
Sharon Su ◽  
Anastasia Makarova ◽  
Todd M. Wilson ◽  
Melody C. Carter ◽  
...  
Keyword(s):  
Mast Cell ◽  
Angiotensin Ii ◽  
Α2 Macroglobulin ◽  
Mast Cell Chymase

scholarly journals Mast Cell Chymase and Kidney Disease

2020 ◽  
Vol 22 (1) ◽  
pp. 302
Author(s):  
Shamila Vibhushan ◽  
Manuela Bratti ◽  
Juan Eduardo Montero-Hernández ◽  
Alaa El Ghoneimi ◽  
Marc Benhamou ◽  
...  
Keyword(s):  
Mast Cell ◽  
Angiotensin Ii ◽  
Mast Cells ◽  
Kidney Disease ◽  
Inflammatory Response ◽  
Inflammatory Mediator ◽  
Total Proteins ◽  
Cytoplasmic Granules ◽  
Physiological Processes ◽  
Mast Cell Chymase

A sizable part (~2%) of the human genome encodes for proteases. They are involved in many physiological processes, such as development, reproduction and inflammation, but also play a role in pathology. Mast cells (MC) contain a variety of MC specific proteases, the expression of which may differ between various MC subtypes. Amongst these proteases, chymase represents up to 25% of the total proteins in the MC and is released from cytoplasmic granules upon activation. Once secreted, it cleaves the targets in the local tissue environment, but may also act in lymph nodes infiltrated by MC, or systemically, when reaching the circulation during an inflammatory response. MC have been recognized as important components in the development of kidney disease. Based on this observation, MC chymase has gained interest following the discovery that it contributes to the angiotensin-converting enzyme’s independent generation of angiotensin II, an important inflammatory mediator in the development of kidney disease. Hence, progress regarding its role has been made based on studies using inhibitors but also on mice deficient in MC protease 4 (mMCP-4), the functional murine counterpart of human chymase. In this review, we discuss the role and actions of chymase in kidney disease. While initially believed to contribute to pathogenesis, the accumulated data favor a more subtle view, indicating that chymase may also have beneficial actions.

scholarly journals Contributions of ACE and mast cell chymase to endogenous angiotensin II generation and leucocyte recruitment in vivo

2011 ◽  
Vol 92 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Chantal Company ◽  
Laura Piqueras ◽  
Yafa Naim Abu Nabah ◽  
Paula Escudero ◽  
Jose Ignacio Blanes ◽  
...  
Keyword(s):  
Mast Cell ◽  
Angiotensin Ii ◽  
Mast Cell Chymase ◽  
Leucocyte Recruitment

Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models

2006 ◽  
Vol 112 (3) ◽  
pp. 668-676 ◽  
Author(s):  
Mizuo Miyazaki ◽  
Shinji Takai ◽  
Denan Jin ◽  
Michiko Muramatsu
Keyword(s):  
Mast Cell ◽  
Angiotensin Ii ◽  
Animal Models ◽  
Mast Cell Chymase

Angiotensin II-generating enzymes, angiotensin-converting enzyme (ACE) and mast cell chymase (CMA1), in gastric inflammation may be regulated by H. pylori and associated cytokines

Pathology ◽  
2009 ◽  
Vol 41 (5) ◽  
pp. 419-427 ◽  
Author(s):  
Stacy Carl-McGrath ◽  
Ilona Gräntzdörffer ◽  
Uwe Lendeckel ◽  
Matthias P. Ebert ◽  
Christoph Röcken
Keyword(s):  
Mast Cell ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
H Pylori ◽  
Mast Cell Chymase

scholarly journals Identification of domains in apoA-I susceptible to proteolysis by mast cell chymase: implications for HDL function

2000 ◽  
Vol 41 (6) ◽  
pp. 975-984
Author(s):  
Miriam Lee ◽  
Patrizia Uboldi ◽  
Daniela Giudice ◽  
Alberico L. Catapano ◽  
Petri T. Kovanen
Keyword(s):  
Mast Cell ◽  
Hdl Function ◽  
Mast Cell Chymase

scholarly journals GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number

2015 ◽  
Vol 459 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Zhuo Zhao ◽  
Hao Wang ◽  
Marina Lin ◽  
Leanne Groban
Keyword(s):  
Mast Cell ◽  
Angiotensin Ii ◽  
Cell Number ◽  
Mast Cell Number

Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-κB-mediated survival signaling☆

2006 ◽  
Vol 312 (8) ◽  
pp. 1289-1298 ◽  
Author(s):  
M LESKINEN ◽  
H HEIKKILA ◽  
M SPEER ◽  
J HAKALA ◽  
M LAINE ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Apoptosis ◽  
Survival Signaling ◽  
Muscle Cell Apoptosis ◽  
Mast Cell Chymase

Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells

Allergy ◽  
2018 ◽  
Author(s):  
Xiaoying Zhou ◽  
Tao Wei ◽  
Christopher W. Cox ◽  
Andrew F. Walls ◽  
Yuan Jiang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Epithelial Cells ◽  
Bronchial Epithelium ◽  
Cell Junction ◽  
Junction Molecules ◽  
Mast Cell Chymase

scholarly journals Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice

2005 ◽  
Vol 145 (4) ◽  
pp. 424-431 ◽  
Author(s):  
Naotaka Shiota ◽  
Eiichi Kakizoe ◽  
Keiko Shimoura ◽  
Tetsuya Tanaka ◽  
Hideki Okunishi
Keyword(s):  
Mast Cell ◽  
Tight Skin ◽  
Mast Cell Chymase ◽  
Chymase Inhibitor
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