scholarly journals Amyloid β Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

2009 ◽  
Vol 182 (9) ◽  
pp. 5778-5788 ◽  
Author(s):  
Man Li ◽  
De-Shu Shang ◽  
Wei-Dong Zhao ◽  
Li Tian ◽  
Bo Li ◽  
...  
Keyword(s):  
T Cells ◽  
Blood Brain Barrier ◽  
Advanced Glycation End Products ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Advanced Glycation ◽  
Ccr5 Expression ◽  
Blood Brain ◽  
Glycation End Products ◽  
End Products

scholarly journals Receptor for advanced glycation end products mediates meningitis‐triggered amyloid‐β accumulation and cognitive impairment

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Tatiana Barichello ◽  
Jaqueline S Generoso ◽  
Vijayasree V Giridharan ◽  
Allan Collodel ◽  
Diogo Dominguini ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Advanced Glycation End Products ◽  
Amyloid Β ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Advanced Glycation End Products Inhibit Both Infection and TransmissionIn Transof HIV-1 from Monocyte-Derived Dendritic Cells to Autologous T Cells

2011 ◽  
Vol 186 (10) ◽  
pp. 5687-5695 ◽  
Author(s):  
Nadine Nasreddine ◽  
Chloé Borde ◽  
Joël Gozlan ◽  
Laurent Bélec ◽  
Vincent Maréchal ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Hiv 1

scholarly journals CCR5 expression on monocytes and T cells: Modulation by transmigration across the blood–brain barrier in vitro

2006 ◽  
Vol 243 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Eroboghene E. Ubogu ◽  
Melissa K. Callahan ◽  
Barbara H. Tucky ◽  
Richard M. Ransohoff
Keyword(s):  
T Cells ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Ccr5 Expression ◽  
Blood Brain

scholarly journals Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment

2017 ◽  
Vol 293 (1) ◽  
pp. 226-244 ◽  
Author(s):  
Juciano Gasparotto ◽  
Carolina S. Girardi ◽  
Nauana Somensi ◽  
Camila T. Ribeiro ◽  
José C. F. Moreira ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Advanced Glycation End Products ◽  
Amyloid Β ◽  
Tau Phosphorylation ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Glycation Increases the Risk of Microbial Traversal through an Endothelial Model of the Human Blood-Brain Barrier after Use of Anesthetics

2020 ◽  
Vol 9 (11) ◽  
pp. 3672
Author(s):  
Veronika Weber ◽  
Heidi Olzscha ◽  
Timo Längrich ◽  
Carla Hartmann ◽  
Matthias Jung ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Human Blood ◽  
Posttranslational Modifications ◽  
Postoperative Delirium ◽  
Brain Barrier ◽  
Advanced Glycation ◽  
Blood Brain ◽  
Glycation End Products ◽  
Essential Nutrient ◽  
The Brain

The function of the human blood–brain barrier (BBB), consisting mainly of the basement membrane and microvascular endothelial cells, is to protect the brain and regulate its metabolism. Dysfunction of the BBB can lead to increased permeability, which can be linked with several pathologies, including meningitis, sepsis, and postoperative delirium. Advanced glycation end products (AGE) are non-enzymatic, posttranslational modifications of proteins, which can affect their function. Increased AGE levels are strongly associated with ageing and degenerative diseases including diabetes. Several studies demonstrated that the formation of AGE interfere with the function of the BBB and may change its permeability for soluble compounds. However, it is still unclear whether AGE can facilitate microbial traversal through the BBB and how small compounds including anesthetics modulate this process. Therefore, we developed a cellular model, which allows for the convenient testing of different factors and compounds with a direct correlation to bacterial traversal through the BBB. Our results demonstrate that both glycation and anesthetics interfere with the function of the BBB and promote microbial traversal. Importantly, we also show that the essential nutrient and antioxidant ascorbic acid, commonly known as vitamin C, can reduce the microbial traversal through the BBB and partly reverse the effects of AGE.

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