INHIBITION OF CHOLINESTERASE IN THE CATTLE GRUB HYPODERMA BOVIS (DIPTERA: OESTRIDAE) AFTER TREATMENT OF THE HOST CATTLE WITH SYSTEMIC INSECTICIDES

1969 ◽  
Vol 101 (5) ◽  
pp. 463-466 ◽  
Author(s):  
C. C. Steward
Keyword(s):  
The Body ◽  
Nervous Systems ◽  
Systemic Insecticides ◽  
First Instar ◽  
Hypoderma Bovis ◽  
Histochemical Evidence ◽  
Acetylthiocholine Iodide ◽  
Central Nervous Systems

AbstractCattle grubs, first-instar larvae of Hypoderma bovis (L.), were removed from nine slaughtered heifers. Two of these heifers had previously been treated with coumaphos, three with Ruelene, and two with trichlorfon. The remaining two heifers were not treated with insecticides and served as sources of control grubs. The grubs, after removal from the hosts and fixation in formalin, were incubated with one of the two cholinesterase substrates, acetylthiocholine iodide or 5-bromoindoxyl acetate. Cholinesterase was completely inhibited in the central nervous systems of the grubs whose hosts were treated with Ruelene. This inhibition was also virtually complete in grubs from heifers treated with trichlorfon and was usually complete in those from the heifers treated with coumaphos. This is presented as histochemical evidence that the three systemic insecticides inhibit the cholinergic enzymes in the grubs, thus causing them to die while still in the body of the host.

Calvarial Eosinophilic Granuloma Simulating Meningioma

1996 ◽  
Vol 9 (5) ◽  
pp. 615-618
Author(s):  
S. Pomonis ◽  
A. Vakis ◽  
M. Grammnou ◽  
E. Machera ◽  
D. Anagnostopoulos ◽  
...  
Keyword(s):  
Eosinophilic Granuloma ◽  
Unknown Origin ◽  
The Body ◽  
Nervous Systems ◽  
Common Location ◽  
Central Nervous Systems

Eosinophilic granuloma, a form of reticuloendothelial proliferation of unknown origin, can involve virtually any site and organ of the body. Involvement of the central nervous systems is very rare, but the skull is a common location. We present a case of a large eosinophilic granuloma of the skull, which on CT? MRI and angiography, was reported as meningiosarcoma. The tumour was totally excised, and histology disclosed an eosinophilic granuloma. Emphasis is given on radiology, and the literature is reviewed.

The nervous systems of Tylodelphys metacercariae (Digenea: Diplostomidae) from the catfish Clarias gariepinus (Clariidae) in freshwater habitats of Tanzania

2015 ◽  
Vol 90 (6) ◽  
pp. 712-718
Author(s):  
F.D. Chibwana ◽  
G. Nkwengulila
Keyword(s):  
Nervous System ◽  
Clarias Gariepinus ◽  
Molecular Techniques ◽  
The Body ◽  
Cranial Cavity ◽  
Enzyme Cytochemistry ◽  
Nervous Systems ◽  
Acetylthiocholine Iodide ◽  
Freshwater Habitats ◽  
The Central Nervous System

AbstractThe nervous systems of three Tylodelphys metacercariae (T. mashonense, Tylodelphys spp. 1 and 2) co-occurring in the cranial cavity of the catfish, Clarias gariepinus, were examined by the activity of acetylthiocholine iodide (AcThI), with the aim of better understanding the arrangement of sensillae on the body surface and the nerve trunks and commissures, for taxonomic purposes. Enzyme cytochemistry demonstrated a comparable orthogonal arrangement in the three metacercariae: the central nervous system (CNS) consisting of a pair of cerebral ganglia, from which anterior and posterior neuronal pathways arise and inter-link by cross-connectives and commissures. However, the number of transverse nerves was significantly different in the three diplostomid metacercariae: Tylodelphys sp. 1 (30), Tylodelphys sp. 2 (21) and T. mashonense (15). The observed difference in the nervous system of the three metacercariae clearly separates them into three species. These findings suggest that consistent differences in the transverse nerves of digenean metacercariae could enable the differentiation of metacercariae to the species level in the absence of molecular techniques. This, however, might require further testing on a larger number of species of digenean metacercariae.

DISTRIBUTION OF CHOLINESTERASE IN THE LARVAE OF HYPODERMA BOVIS AND HYPODERMA LINEATUM (DIPTERA: OESTRIDAE) AND ITS INHIBITION BY SYSTEMIC INSECTICIDES

1967 ◽  
Vol 99 (4) ◽  
pp. 340-350 ◽  
Author(s):  
C. C. Steward
Keyword(s):  
Body Wall ◽  
Fat Body ◽  
Histochemical Demonstration ◽  
The Body ◽  
Lumbar Region ◽  
Salivary Duct ◽  
Ring Gland ◽  
Hypoderma Bovis ◽  
Acetylthiocholine Iodide ◽  
The Central Nervous System

AbstractLarvae of Hypoderma bovis (L.) and H. lineatum (De Vill.) when incubated with the substrate acetylthiocholine iodide showed the presence of cholinesterase throughout the central nervous system and sense organs, in gonads, oenocytes, Malpighian tubes, anlagen of adult structures, part of the posterior midintestine, and at the junctions of the muscles of the body wall. Incubation with the substrate 5-bromoindoxyl acetate showed all the aforementioned and in addition demonstrated the presence of aliesterase (organophosphorus-sensitive esterase) in the cell cytoplasm of all the midintestinal epithelium, the ring gland, tracheal epithelium, salivary duct epithelium, and in the perineurium of the nerve sheath. Aromesterase (organophosphorus-resistant esterase) was particularly abundant in the epithelium of the midintestine. Lipase was prominent in the lipid droplets of the fat body cells and in similar droplets in the haemocytes.When the larvae or their tissues, prior to incubation with the substrates, were treated with any one of the three organophosphorus insecticides coumaphos (Co-Ral), trichlorfon (Neguvon, Dipterex), or Ruelene, the cholinesterase was inhibited and so was much of the aliesterase, but not the aromesterase or lipase. Fixation of the larval tissues in formalin did not result in loss of enzyme activity, but on the other hand was not necessary for good histochemical demonstration of the enzymes.It is concluded that these insecticides by their anticholinesterase action kill the first-instar cattle grubs before the latter can migrate to the lumbar region of the bovine host.

Bovine hypodermatosis in Stavropol region: distribution, pathogenesis, veterinary and sanitary assessment of slaughter products

2020 ◽  
pp. 7-10
Author(s):  
Vasiliy P. Petropavlovsky ◽  
◽  
Vyacheslav V. Marchenko ◽  
Lyudmila S. Vikulova ◽  
Olga D. Chepeleva ◽  
...  
Keyword(s):  
Preventive Measures ◽  
Climatic Conditions ◽  
The Body ◽  
Erythrocyte Aggregation ◽  
Economic Damage ◽  
Hydropic Degeneration ◽  
Hypoderma Lineatum ◽  
Hypoderma Bovis ◽  
Stavropol Region ◽  
Histomorphological Changes

Summary. Data on distribution of hypodermatosis among large horned cattle in Stavropol region are presented in the article. It was proved that this pathology is widespread in this region. From 12% to 38% of animals from the total number of examined livestock are affected. Ordinary subcutaneous botfly (stroma) Hypoderma bovis de Geer and south subcutaneous botfly (pischevodnik) Hypoderma lineatum de Villers parasites on large horned cattle. The species ratio of gadflies is: Hypoderma bovis (de Gee - 61.1%, Hypoderma lineatum de Villers - 38.9%). The disease is widespread in all climatic zones of Stavropol region. Animals of all age and sex groups are infected, but young animals are more often affected. Linear relationship between the indicators of the transformation of climatic conditions in Stavropol region, the spread of hypodermatosis and the timing of treatment and preventive measures were determined. Authors proved that the complete death of H. bovis and H. lineatum imago (regardless of the time of their hatching) was noted when the temperature drops to -3°C for two days. Thus, this temperature determines the start of treatment and preventive measures against hypodermatosis in the area of animal welfare. When analyzing the histomorphological changes caused by H. bovis and H. lineatum in the body of large horned cattle, perforation of the skin, swelling of adjacent tissues, disorganization of the stroma and structural elements, erythrocyte aggregation, hemorrhages, hydropic degeneration of cellular elements, tissue necrosis, polymorphonuclear leukocyte infiltration of affected organs and tissues were observed. The data on pathogenesis were presented, the analysis of economic damage and the veterinary and sanitary assessment of the products of slaughter of cattle with hypodermatosis were carried out.

Therapeutic Potential of Agonists and Antagonists of A1, A2a, A2b and A3 Adenosine Receptors

2019 ◽  
Vol 25 (26) ◽  
pp. 2892-2905 ◽  
Author(s):  
Sumit Jamwal ◽  
Ashish Mittal ◽  
Puneet Kumar ◽  
Dana M. Alhayani ◽  
Amal Al-Aboudi
Keyword(s):  
Nervous System ◽  
Therapeutic Potential ◽  
The Body ◽  
Membrane Receptors ◽  
Physiological Importance ◽  
Physiological Processes ◽  
Central Nervous Systems ◽  
Energy Consuming ◽  
Metabolic Dysfunctions ◽  
G Protein Coupled

Adenosine is a naturally occurring nucleoside and an essential component of the energy production and utilization systems of the body. Adenosine is formed by the degradation of adenosine-triphosphate (ATP) during energy-consuming processes. Adenosine regulates numerous physiological processes through activation of four subtypes of G-protein coupled membrane receptors viz. A1, A2A, A2B and A3. Its physiological importance depends on the affinity of these receptors and the extracellular concentrations reached. ATP acts as a neurotransmitter in both peripheral and central nervous systems. In the peripheral nervous system, ATP is involved in chemical transmission in sensory and autonomic ganglia, whereas in central nervous system, ATP, released from synaptic terminals, induces fast excitatory postsynaptic currents. ATP provides the energetics for all muscle movements, heart beats, nerve signals and chemical reactions inside the body. Adenosine has been traditionally considered an inhibitor of neuronal activity and a regulator of cerebral blood flow. Since adenosine is neuroprotective against excitotoxic and metabolic dysfunctions observed in neurological and ocular diseases, the search for adenosinerelated drugs regulating adenosine transporters and receptors can be important for advancement of therapeutic strategies against these diseases. This review will summarize the therapeutic potential and recent SAR and pharmacology of adenosine and its receptor agonists and antagonists.

GABA-, histamine-, and FMRFamide-immunoreactivity in the visual, vestibular and central nervous systems ofHermissenda crassicornis

2017 ◽  
Vol 525 (16) ◽  
pp. 3514-3528 ◽  
Author(s):  
Marissa P. Webber ◽  
James W. S. Thomson ◽  
Johnny Buckland-Nicks ◽  
Roger P. Croll ◽  
Russell C. Wyeth
Keyword(s):  
Nervous Systems ◽  
Central Nervous Systems

Stem treatments to cotton with systemic insecticides against Heliothis zea (Boddie) and H. virescens (F.)

1968 ◽  
Vol 57 (4) ◽  
pp. 553-558
Author(s):  
R. L. Ridgway ◽  
L. A. Bariola ◽  
S. L. Jones ◽  
W. L. Lowry
Keyword(s):  
Heliothis Zea ◽  
Large Field ◽  
Field Cage ◽  
Systemic Action ◽  
American Cyanamid ◽  
Systemic Insecticides ◽  
Dimethyl Phosphate ◽  
First Instar ◽  
Sucrose Solutions ◽  
Cotton Plants

Laboratory and field-cage studies were conducted in Texas in 1965 to evaluate treatments of the systemic insecticides, Azodrin (3-hydroxy-N-methyl-cis-crotonamide dimethyl phosphate), Bidrin (3-hydroxy-N, N dimethyl-cis-crotonamide dimethyl phosphate), American Cyanamid CL-47031 (cyclic ethylene (diethoxy-phosphinyl) dithioimidocarbonate) and Temik (2-methyl-2-(methylthio) propion-aldehyde O-(methylcarbamoyl) oxime), applied incorporated in lanolin to the stems of cotton plants against Heliothis zea (Boddie) and H. virescens (F.). Reductions in numbers of developing larvae of H. zea were substantial on individual plants the stems of which had been treated with Azodrin or CL-47031 and which were artificially infested with eggs. When first-instar larvae of H. zea or H. virescens were caged on plants 3, 7 or 14 days after stem treatment with 2.5, 5.0 or 100 mg. Azodrin, Bidrin or CL-47031 per plant, net mortalities ranged from 21 to 80 per cent after three days. The mortality of adults of H. zea provided with sucrose solutions containing 1 p.p.m. of the systemic insecticides indicated that Azodrin and Bidrin were about equally toxic and much more so than CL-47031 and Temik, and that of adults caged on individual plants in flower that had been treated with Azodrin or CL-47031 suggested that the moths may be killed by the systemic action of these insecticides translocated to the nectar. When adults of H. virescens were released on plants each treated with Azodrin at 25 or 30 mg. in large field cages, reductions in the numbers of eggs deposited, attributed to the effect on the moths of the insecticide in the nectar, and in the numbers of developing larvae, were substantial. Azodrin was the most consistently effective of the four insecticides evaluated.

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