Modeling the allosteric effect in visual rhodopsin due to phosphorylation

2018 ◽  
Vol 18 (2) ◽  
pp. 94-98
Author(s):  
N. Vasilieva-Vashakmadze ◽  
G. Lekishvili ◽  
P. Toidze ◽  
R. Gakhokidze
Keyword(s):  
Allosteric Effect ◽  
Visual Rhodopsin

Functional expression in vitro of bovine visual rhodopsin

1990 ◽  
Vol 3 (5) ◽  
pp. 453-458 ◽  
Author(s):  
S.A. Zozulya ◽  
V.V. Gurevich ◽  
T.A. Zvyaga ◽  
E.P. Shirokova ◽  
I.L. Dumler ◽  
...  
Keyword(s):  
Functional Expression ◽  
Visual Rhodopsin

scholarly journals Dual Allosteric Effect in Glycine/NMDA Receptor Antagonism: A Comparative QSAR Approach

2010 ◽  
Vol 3 (10) ◽  
pp. 3167-3185 ◽  
Author(s):  
Manish Sharma ◽  
Vipin B. Gupta
Keyword(s):  
Nmda Receptor ◽  
Allosteric Effect ◽  
Receptor Antagonism

scholarly journals In silico analysis of Glanzmann variants of Calf-1 domain of αIIbβ3 integrin revealed dynamic allosteric effect

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Matthieu Goguet ◽  
Tarun Jairaj Narwani ◽  
Rachel Petermann ◽  
Vincent Jallu ◽  
Alexandre G. de Brevern
Keyword(s):  
In Silico ◽  
In Silico Analysis ◽  
Allosteric Effect ◽  
Αiibβ3 Integrin ◽  
Silico Analysis

Highly selective and efficient extraction of two Pb2+ ions with a p-tert-butylcalix[6]arene hexacarboxylic acid ligand: an allosteric effect in extraction

RSC Advances ◽  
2013 ◽  
Vol 3 (48) ◽  
pp. 25950 ◽  
Author(s):  
Birendra Babu Adhikari ◽  
Manju Gurung ◽  
Anup Basnet Chetry ◽  
Hidetaka Kawakita ◽  
Keisuke Ohto
Keyword(s):  
Allosteric Effect ◽  
Acid Ligand ◽  
Efficient Extraction

scholarly journals The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Oliver Vöcking ◽  
Lucas Leclère ◽  
Harald Hausen
Keyword(s):  
In Situ Hybridization ◽  
Photoreceptor Cells ◽  
Visual Cycle ◽  
Phylogenetic Distribution ◽  
Enzymatic Process ◽  
Antibody Staining ◽  
The Individual ◽  
Functional Components ◽  
Visual Rhodopsin

Abstract Background The process of photoreception in most animals depends on the light induced isomerization of the chromophore retinal, bound to rhodopsin. To re-use retinal, the all-trans-retinal form needs to be re-isomerized to 11-cis-retinal, which can be achieved in different ways. In vertebrates, this mostly includes a stepwise enzymatic process called the visual cycle. The best studied re-isomerization system in protostomes is the rhodopsin-retinochrome system of cephalopods, which consists of rhodopsin, the photoisomerase retinochrome and the protein RALBP functioning as shuttle for retinal. In this study we investigate the expression of the rhodopsin-retinochrome system and functional components of the vertebrate visual cycle in a polyplacophoran mollusk, Leptochiton asellus, and examine the phylogenetic distribution of the individual components in other protostome animals. Results Tree-based orthology assignments revealed that orthologs of the cephalopod retinochrome and RALBP are present in mollusks outside of cephalopods. By mining our dataset for vertebrate visual cycle components, we also found orthologs of the retinoid binding protein RLBP1, in polyplacophoran mollusks, cephalopods and a phoronid. In situ hybridization and antibody staining revealed that L. asellus retinochrome is co-expressed in the larval chiton photoreceptor cells (PRCs) with the visual rhodopsin, RALBP and RLBP1. In addition, multiple retinal dehydrogenases are expressed in the PRCs, which might also contribute to the rhodopsin-retinochrome system. Conclusions We conclude that the rhodopsin-retinochrome system is a common feature of mollusk PRCs and predates the origin of cephalopod eyes. Our results show that this system has to be extended by adding further components, which surprisingly, are shared with vertebrates.

Fine tuning of phosphodiesterasse models activity using allosteric effect of metal ion coordination

2003 ◽  
Vol 96 (1) ◽  
pp. 193
Author(s):  
Larisa A. Mokhir ◽  
Markus Hoppe ◽  
Hans Pritzkow ◽  
Igor O. Fritsky ◽  
Roland Kraemer
Keyword(s):  
Metal Ion ◽  
Fine Tuning ◽  
Allosteric Effect

Conformational dynamics and allosteric effect modulated by the unique zinc-binding motif in class IIa HDACs

2019 ◽  
Vol 21 (23) ◽  
pp. 12173-12183 ◽  
Author(s):  
Huawei Liu ◽  
Fan Zhang ◽  
Kai Wang ◽  
Xiaowen Tang ◽  
Ruibo Wu
Keyword(s):  
Histone Deacetylases ◽  
Conformational Dynamics ◽  
Zinc Binding ◽  
Binding Motif ◽  
Allosteric Effect ◽  
Class Iia Hdacs ◽  
Zinc Binding Motif

Class IIa histone deacetylases (HDACs) have been considered as potential targets for the treatment of several diseases.

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