scholarly journals Dual Allosteric Effect in Glycine/NMDA Receptor Antagonism: A Comparative QSAR Approach

2010 ◽  
Vol 3 (10) ◽  
pp. 3167-3185 ◽  
Author(s):  
Manish Sharma ◽  
Vipin B. Gupta
Keyword(s):  
Nmda Receptor ◽  
Allosteric Effect ◽  
Receptor Antagonism

scholarly journals Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism

2010 ◽  
Vol 128 (3) ◽  
pp. 419-432 ◽  
Author(s):  
Joanna C. Neill ◽  
Samuel Barnes ◽  
Samantha Cook ◽  
Ben Grayson ◽  
Nagi F. Idris ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Animal Models ◽  
Cognitive Dysfunction ◽  
Negative Symptoms ◽  
Receptor Antagonism

Estrogen and NMDA receptor antagonism: effects upon reference and working memory

1999 ◽  
Vol 381 (2-3) ◽  
pp. 93-99 ◽  
Author(s):  
Iain A Wilson ◽  
Jukka Puoliväli ◽  
Taneli Heikkinen ◽  
Paavo Riekkinen
Keyword(s):  
Working Memory ◽  
Nmda Receptor ◽  
Receptor Antagonism

NMDA Receptor Antagonism for Neuroprotection in a Canine Model of Hypothermic Circulatory Arrest

2021 ◽  
Vol 260 ◽  
pp. 177-189
Author(s):  
Katherine Giuliano ◽  
Eric Etchill ◽  
Xun Zhou ◽  
Cecillia Lui ◽  
Alejandro Suarez-Pierre ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Circulatory Arrest ◽  
Canine Model ◽  
Hypothermic Circulatory Arrest ◽  
Receptor Antagonism

Regulation of motor neuron dendrite growth by NMDA receptor activation

Development ◽  
1994 ◽  
Vol 120 (11) ◽  
pp. 3063-3071 ◽  
Author(s):  
R.G. Kalb
Keyword(s):  
Nmda Receptor ◽  
Motor Neuron ◽  
Cell Body ◽  
Motor Neurons ◽  
Receptor Activation ◽  
Dendrite Growth ◽  
Postnatal Life ◽  
Receptor Antagonism ◽  
Neuron Cell Body ◽  
Early Postnatal Life

Spinal motor neurons undergo great changes in morphology, electrophysiology and molecular composition during development. Some of this maturation occurs postnatally when limbs are employed for locomotion, suggesting that neuronal activity may influence motor neuron development. To identify features of motor neurons that might be regulated by activity we first examined the structural development of the rat motor neuron cell body and dendritic tree labeled with cholera toxin-conjugated horseradish peroxidase. The motor neuron cell body and dendrites in the radial and rostrocaudal axes grew progressively over the first month of life. In contrast, the growth of the dendritic arbor/cell and number of dendritic branches was biphasic with overabundant growth followed by regression until the adult pattern was achieved. We next examined the influence of neurotransmission on the development of these motor neuron features. We found that antagonism of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor inhibited cell body growth and dendritic branching in early postnatal life but had no effect on the maximal extent of dendrite growth in the radial and rostrocaudal axes. The effects of NMDA receptor antagonism on motor neurons and their dendrites was temporally restricted; all of our anatomic measures of dendrite structure were resistant to NMDA receptor antagonism in adults. These results suggest that the establishment of mature motor neuron dendritic architecture results in part from dendrite growth in response to afferent input during a sensitive period in early postnatal life.

Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides

2001 ◽  
Vol 41 (7) ◽  
pp. 801-810 ◽  
Author(s):  
Rebecca C. Klein ◽  
Scott E. Warder ◽  
Zygmunt Galdzicki ◽  
Francis J. Castellino ◽  
Mary Prorok
Keyword(s):  
Nmda Receptor ◽  
Receptor Antagonism

scholarly journals Reverse Translation of Clinical Electrophysiological Biomarkers in Behaving Rodents under Acute and Chronic NMDA Receptor Antagonism

2014 ◽  
Vol 40 (3) ◽  
pp. 719-727 ◽  
Author(s):  
Elyse M Sullivan ◽  
Patricia Timi ◽  
L Elliot Hong ◽  
Patricio O'Donnell
Keyword(s):  
Nmda Receptor ◽  
Receptor Antagonism ◽  
Reverse Translation
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