scholarly journals Serum Uric Acid Levels in Acute Ischemic Stroke: A Study of 100 Patients

2011 ◽  
Author(s):  
Patil
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid

Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke

2015 ◽  
Vol 53 (3) ◽  
pp. 1753-1759 ◽  
Author(s):  
Zhongchao Wang ◽  
Yanlin Lin ◽  
Yuxiu Liu ◽  
Ying Chen ◽  
Bin Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid

Lack of association between serum uric acid levels and outcome in acute ischemic stroke

2012 ◽  
Vol 319 (1-2) ◽  
pp. 51-55 ◽  
Author(s):  
Irene Miedema ◽  
Maarten Uyttenboogaart ◽  
Marcus Koch ◽  
Berry Kremer ◽  
Jacques de Keyser ◽  
...  
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid

scholarly journals Association between serum uric acid and carotid disease in patients with atherosclerotic acute ischemic stroke

Vascular ◽  
2018 ◽  
Vol 27 (1) ◽  
pp. 19-26 ◽  
Author(s):  
José Carlos Arévalo-Lorido ◽  
Juana Carretero-Gómez ◽  
Nicolás Roberto Robles Pérez-Monteoliva
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Pearson Correlation ◽  
Vascular Wall ◽  
Carotid Disease ◽  
Cross Sectional ◽  
Stroke Registry ◽  
Media Thickness

Aim The role of serum uric acid in ischemic stroke is controversial. On the one hand, it has a role as neuroprotectant in acute phase, but on the other hand, it may promote atherosclerosis in carotid arteries. Our aim is to investigate the association of serum uric acid levels at admission of acute ischemic stroke patients with carotid disease. Methods Cross-sectional study of patients admitted due to acute ischemic stroke. Clinical and laboratory variables were recorded. The carotid disease was defined based on the findings of carotid echography intima to media thickness and stenosis. Patients were grouped according to these findings. Robust statistical methods were applied into analysis. Results A total of 245 patients were recruited through a stroke registry. Their values of serum uric acid were related to both carotid intima to media thickness and stenosis showing a positive relationship between serum uric acid levels and intima to media thickness by Pearson correlation ( p < 0.05). Similarly, after adjusting for all potential confounders, eGFR, glucose, age and serum uric acid levels, (OR 1.26 (95% CI 1.04 −1.52, p¼0.01), were identified as independent predictors for having a intima to media thickness ≥1 mm. Similarly, by grouping patients in tertiles of the serum uric acid distribution, we found a predominantly greater carotid disease in the tertile with the highest levels of serum uric acid ( p < 0.005). Conclusion Our study supports the hypotheses that serum uric acid levels have different roles in the case of ischemic stroke. Its effects on the vascular wall contribute to the development of atherosclerosis and carotid disease.

Abstract TP163: Metabolic Syndrome, Raised Serum Uric Acid And Poor Leptomeningeal Collateral Status In Patients With Acute Ischemic Strokes

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Bijoy K Menon ◽  
Eric E Smith ◽  
Shelagh B Coutts ◽  
Donald G Welsh ◽  
James E Faber ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Cerebral Artery ◽  
Clinical Information ◽  
Stroke Registry ◽  
Cross Connect

Introduction: Leptomeningeal collaterals are native (pre-existing) anastomoses that cross-connect a small number of distal-most arterioles within the crowns of the cerebral artery trees. We seek to identify potentially modifiable determinants associated with variability in leptomeningeal collateral status in patients with acute ischemic stroke. Methods: Data is from the Keimyung Stroke Registry, a prospectively collected dataset of patients with acute ischemic stroke from Daegu, South Korea. Patients with M 1 segment middle cerebral artery (MCA) +/- intracranial internal carotid artery (ICA) occlusions on baseline CT-angio from May 2004 to July 2009 were included in the study.Baseline and follow-up imaging was analyzed at the imaging core lab of the Calgary Stroke Program. Two readers blinded to all clinical information assessed leptomeningeal collaterals on baseline CT-angio by consensus using the regional leptomeningeal score (rLMC). Results: Of 206 patients[mean age66.9±11.6 years, median baseline NIHSS 14 (IQR11-20), median stroke symptom onset to CT-angio time 166 minutes (IQR 96-262)], 133 patients (64.6%) had poor collateral status at baseline (rLMC score 11-20). On univariate analyses, patients with poor collateral status at baseline were older, hypertensive, had higher blood glucose values, higher white blood cell count at baseline, higher D-dimer and serum uric acid levels (measured next day morning) and were more likely to have metabolic syndrome as per ATP III criteria. Multivariable modeling identified metabolic syndrome (OR 3.22 95% CI 1.69-6.15, p<0.001), raised serum uric acid (per 1mg/dl OR 1.35 95% CI 1.12-1.62, p<0.01) and age (per year, OR 1.03 95% CI 1-1.05, p=0.03) as independent predictors of poor leptomeningeal collateral status at baseline. Conclusion: Metabolic syndrome and hyperuricemia are modifiable determinants associated with poor leptomeningeal collateral status in patients with acute ischemic stroke. This knowledge could potentially help in focusing research on appropriate therapeutic strategies for modulating function of leptomeningeal collaterals.

scholarly journals Allopurinol as a Preventive Contrivance after Acute Ischemic Stroke in Patients with a High Level of Serum Uric Acid: A Randomized, Controlled Trial

2013 ◽  
Vol 23 (2) ◽  
pp. 134-139 ◽  
Author(s):  
Ali Akbar Taheraghdam ◽  
Ehsan Sharifipour ◽  
Ali Pashapour ◽  
Shahryar Namdar ◽  
Abolfazl Hatami ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
High Level

scholarly journals Serum Uric Acid – Risk Factor for Acute Ischemic Stroke and Poor Outcomes

Cureus ◽  
2019 ◽  
Author(s):  
Muhammad Ali Tariq ◽  
Sohaib A Shamim ◽  
Kiran F Rana ◽  
Aisha Saeed ◽  
Bilal Haider Malik
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Poor Outcomes
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