scholarly journals Development of a novel bioactive titanium membrane with alkali treatment for bone regeneration

2020 ◽  
Vol 39 (5) ◽  
pp. 877-882
Author(s):  
Hanako UMEHARA ◽  
Kazuya DOI ◽  
Yoshifumi OKI ◽  
Reiko KOBATAKE ◽  
Yusuke MAKIHARA ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Alkali Treatment ◽  
Titanium Membrane

scholarly journals Novel bioactive titanium membrane for bone regeneration+ effect of alkali treatment

2019 ◽  
Vol 30 (S19) ◽  
pp. 124-124
Author(s):  
Hanako Umehara ◽  
Kazuya Doi ◽  
Reiko Kobatake ◽  
Yusuke Makihara ◽  
Yosihumi Oki ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Alkali Treatment ◽  
Regeneration Effect ◽  
Titanium Membrane

scholarly journals Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

Polymers ◽  
2015 ◽  
Vol 7 (10) ◽  
pp. 2061-2077 ◽  
Author(s):  
Jin-Hyung Shim ◽  
Joo-Yun Won ◽  
Su-Jin Sung ◽  
Dong-Hyuk Lim ◽  
Won-Soo Yun ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Beagle Dogs ◽  
3D Printed ◽  
Titanium Membrane

scholarly journals Immunomodulatory Properties and Osteogenic Activity of Polyetheretherketone Coated with Titanate Nanonetwork Structures

2022 ◽  
Vol 23 (2) ◽  
pp. 612
Author(s):  
Yuanyuan Yang ◽  
Honghao Zhang ◽  
Satoshi Komasa ◽  
Tetsuji Kusumoto ◽  
Shinsuke Kuwamoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Regeneration ◽  
Inflammatory Responses ◽  
Alkali Treatment ◽  
Chemical Properties ◽  
Cell Behaviors ◽  
Osteogenic Activity ◽  
Plasma Sputtering ◽  
Physical And Chemical ◽  
Cell Adhesion And Proliferation

Polyetheretherketone (PEEK) is a potential substitute for conventional metallic biomedical implants owing to its superior mechanical and chemical properties, as well as biocompatibility. However, its inherent bio-inertness and poor osseointegration limit its use in clinical applications. Herein, thin titanium films were deposited on the PEEK substrate by plasma sputtering, and porous nanonetwork structures were incorporated on the PEEK surface by alkali treatment (PEEK-TNS). Changes in the physical and chemical characteristics of the PEEK surface were analyzed to establish the interactions with cell behaviors. The osteoimmunomodulatory properties were evaluated using macrophage cells and osteoblast lineage cells. The functionalized nanostructured surface of PEEK-TNS effectively promoted initial cell adhesion and proliferation, suppressed inflammatory responses, and induced macrophages to anti-inflammatory M2 polarization. Compared with PEEK, PEEK-TNS provided a more beneficial osteoimmune environment, including increased levels of osteogenic, angiogenic, and fibrogenic gene expression, and balanced osteoclast activities. Furthermore, the crosstalk between macrophages and osteoblast cells showed that PEEK-TNS could provide favorable osteoimmunodulatory environment for bone regeneration. PEEK-TNS exhibited high osteogenic activity, as indicated by alkaline phosphatase activity, osteogenic factor production, and the osteogenesis/osteoclastogenesis-related gene expression of osteoblasts. The study establishes that the fabrication of titanate nanonetwork structures on PEEK surfaces could extract an adequate immune response and favorable osteogenesis for functional bone regeneration. Furthermore, it indicates the potential of PEEK-TNS in implant applications.

Evaluation of a Newly Designed Microperforated Pure Titanium Membrane for Guided Bone Regeneration

2019 ◽  
Vol 34 (2) ◽  
pp. 411-422 ◽  
Author(s):  
Hiroshi Hasegawa ◽  
Seiichiro Masui ◽  
Hiroshi Ishihata ◽  
Tetsuharu Kaneko ◽  
Daichi Ishida ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Pure Titanium ◽  
Guided Bone Regeneration ◽  
Titanium Membrane

Vertical ridge augmentation with a honeycomb structure titanium membrane: A technical note for three-dimensional curvature bending method

2020 ◽  
Author(s):  
Tomohiro Ishikawa ◽  
Daisuke Ueno
Keyword(s):  
Bone Regeneration ◽  
Animal Studies ◽  
Fibrous Tissue ◽  
Three Dimensional ◽  
External Pressure ◽  
Honeycomb Structure ◽  
Technical Note ◽  
Ridge Augmentation ◽  
Bending Process ◽  
Titanium Membrane

Guided bone regeneration (GBR) is the most commonly used technique for vertical ridge augmentation (VRA), and is popular because it is less invasive and highly formative. Since the augmented site is exposed to external pressure, it is preferable to support the membrane by a framework in order to maintain the shape of the VRA. Recently, a titanium framework reinforced ultrafine titanium membrane was developed by laser processing technology. The technique allows microperforations to be made (φ20 μm) into a titanium membrane, which is expected to prevent fibrous tissue ingrowth from outside the membrane. In addition, significant bone regeneration has been confirmed on ridge defects in previous animal studies. However, the membrane tends to crumple during the bending process because it is very thin (20 μm), so the bending procedures are technically sensitive. Since this titanium honeycomb membrane was first approved for clinical use in Japan, no international clinical reports have been published. The purpose of this case report is to describe a technical note for a three- dimensional curvature bending method in VRA using the newly developed honeycomb structure Ti-membrane.

scholarly journals The Mechanical Properties and Biometrical Effect of 3D Preformed Titanium Membrane for Guided Bone Regeneration on Alveolar Bone Defect

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
So-Hyoun Lee ◽  
Jong-Hoon Moon ◽  
Chang-Mo Jeong ◽  
Eun-Bin Bae ◽  
Chung-Eun Park ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Three Dimensional ◽  
Compressive Load ◽  
Guided Bone Regeneration ◽  
Load Test ◽  
Mechanical Stiffness ◽  
Titanium Membrane

The purpose of this study is to evaluate the effect of three-dimensional preformed titanium membrane (3D-PFTM) to enhance mechanical properties and ability of bone regeneration on the peri-implant bone defect. 3D-PFTMs by new mechanically compressive molding technology and manually shaped- (MS-) PFTMs by hand manipulation were applied in artificial peri-implant bone defect model for static compressive load test and cyclic fatigue load test. In 12 implants installed in the mandibular of three beagle dogs, six 3D-PFTMs, and six collagen membranes (CM) randomly were applied to 2.5 mm peri-implant buccal bone defect with particulate bone graft materials for guided bone regeneration (GBR). The 3D-PFTM group showed about 7.4 times higher mechanical stiffness and 5 times higher fatigue resistance than the MS-PFTM group. The levels of the new bone area (NBA, %), the bone-to-implant contact (BIC, %), distance from the new bone to the old bone (NB-OB, %), and distance from the osseointegration to the old bone (OI-OB, %) were significantly higher in the 3D-PFTM group than the CM group (p<.001). It was verified that the 3D-PFTM increased mechanical properties which were effective in supporting the space maintenance ability and stabilizing the particulate bone grafts, which led to highly efficient bone regeneration.

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