scholarly journals Novel bioactive titanium membrane for bone regeneration+ effect of alkali treatment

2019 ◽  
Vol 30 (S19) ◽  
pp. 124-124
Author(s):  
Hanako Umehara ◽  
Kazuya Doi ◽  
Reiko Kobatake ◽  
Yusuke Makihara ◽  
Yosihumi Oki ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Alkali Treatment ◽  
Regeneration Effect ◽  
Titanium Membrane

scholarly journals Development of a novel bioactive titanium membrane with alkali treatment for bone regeneration

2020 ◽  
Vol 39 (5) ◽  
pp. 877-882
Author(s):  
Hanako UMEHARA ◽  
Kazuya DOI ◽  
Yoshifumi OKI ◽  
Reiko KOBATAKE ◽  
Yusuke MAKIHARA ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Alkali Treatment ◽  
Titanium Membrane

scholarly journals Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release

RSC Advances ◽  
2018 ◽  
Vol 8 (50) ◽  
pp. 28546-28554 ◽  
Author(s):  
Antonio G. B. Castro ◽  
Dennis W. P. M. Löwik ◽  
Mies J. van Steenbergen ◽  
John A. Jansen ◽  
Jeroen J. J. P. van den Beucken ◽  
...  
Keyword(s):  
Thermal Treatment ◽  
Sustained Release ◽  
Bone Regeneration ◽  
Positive Response ◽  
Guided Bone Regeneration ◽  
Regeneration Effect

Thermal treatment resulted in a sustained release of simvastatin and a positive response from rBMSCs.

scholarly journals Evaluation of the Bone Regeneration Effect of Recombinant Human Bone Morphogenic Protein-2 on Subperiosteal Bone Graft in the Rat Calvarial Model

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1613
Author(s):  
Eunhye Jang ◽  
Ja-Youn Lee ◽  
Eun-Young Lee ◽  
Hyun Seok
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Human Bone ◽  
Control Group ◽  
New Bone Formation ◽  
Morphogenetic Protein ◽  
Regeneration Effect ◽  
Recombinant Human Bone

The aim of this study was to evaluate the bone regeneration effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on a subperiosteal bone graft in a rat model. A subperiosteal space was made on the rat calvarium, and anorganic bovine bone (ABB), ABB/low bone morphogenetic protein (BMP) (5 µg), and ABB/high BMP (50 µg) were grafted as subperiosteal bone grafts. The new bone formation parameters of bone volume (BV), bone mineral density (BMD), trabecular thickness (TbTh), and trabecular spacing (TbSp) were evaluated by microcomputed tomography (µ-CT), and a histomorphometric analysis was performed to evaluate the new bone formation area. The expression of osteogenic markers, such as bone sialoprotein (BSP) and osteocalcin, were evaluated by immunohistochemistry (IHC). The ABB/high BMP group showed significantly higher BV than the ABB/low BMP (p = 0.004) and control groups (p = 0.000) and higher TbTh than the control group (p = 0.000). The ABB/low BMP group showed significantly higher BV, BMD, and TbTh than the control group (p = 0.002, 0.042, and 0.000, respectively). The histomorphometry showed significantly higher bone formation in the ABB/low and high BMP groups than in the control group (p = 0.000). IHC showed a high expression of BSP and osteocalcin in the ABB/low and high BMP groups. Subperiosteal bone grafts with ABB and rhBMP-2 have not been studied. In our study, we confirmed that rhBMP-2 contributes to new bone formation in a subperiosteal bone graft with ABB.

scholarly journals Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

Polymers ◽  
2015 ◽  
Vol 7 (10) ◽  
pp. 2061-2077 ◽  
Author(s):  
Jin-Hyung Shim ◽  
Joo-Yun Won ◽  
Su-Jin Sung ◽  
Dong-Hyuk Lim ◽  
Won-Soo Yun ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Beagle Dogs ◽  
3D Printed ◽  
Titanium Membrane

scholarly journals Immunomodulatory Properties and Osteogenic Activity of Polyetheretherketone Coated with Titanate Nanonetwork Structures

2022 ◽  
Vol 23 (2) ◽  
pp. 612
Author(s):  
Yuanyuan Yang ◽  
Honghao Zhang ◽  
Satoshi Komasa ◽  
Tetsuji Kusumoto ◽  
Shinsuke Kuwamoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Regeneration ◽  
Inflammatory Responses ◽  
Alkali Treatment ◽  
Chemical Properties ◽  
Cell Behaviors ◽  
Osteogenic Activity ◽  
Plasma Sputtering ◽  
Physical And Chemical ◽  
Cell Adhesion And Proliferation

Polyetheretherketone (PEEK) is a potential substitute for conventional metallic biomedical implants owing to its superior mechanical and chemical properties, as well as biocompatibility. However, its inherent bio-inertness and poor osseointegration limit its use in clinical applications. Herein, thin titanium films were deposited on the PEEK substrate by plasma sputtering, and porous nanonetwork structures were incorporated on the PEEK surface by alkali treatment (PEEK-TNS). Changes in the physical and chemical characteristics of the PEEK surface were analyzed to establish the interactions with cell behaviors. The osteoimmunomodulatory properties were evaluated using macrophage cells and osteoblast lineage cells. The functionalized nanostructured surface of PEEK-TNS effectively promoted initial cell adhesion and proliferation, suppressed inflammatory responses, and induced macrophages to anti-inflammatory M2 polarization. Compared with PEEK, PEEK-TNS provided a more beneficial osteoimmune environment, including increased levels of osteogenic, angiogenic, and fibrogenic gene expression, and balanced osteoclast activities. Furthermore, the crosstalk between macrophages and osteoblast cells showed that PEEK-TNS could provide favorable osteoimmunodulatory environment for bone regeneration. PEEK-TNS exhibited high osteogenic activity, as indicated by alkaline phosphatase activity, osteogenic factor production, and the osteogenesis/osteoclastogenesis-related gene expression of osteoblasts. The study establishes that the fabrication of titanate nanonetwork structures on PEEK surfaces could extract an adequate immune response and favorable osteogenesis for functional bone regeneration. Furthermore, it indicates the potential of PEEK-TNS in implant applications.

Bone Regeneration Effect of Cassia occidentalis Linn. Extract and Its Isolated Compounds

2021 ◽  
pp. 61-79
Author(s):  
Brijesh Kumar ◽  
Vikas Bajpai ◽  
Vikaskumar Gond ◽  
Subhashis Pal ◽  
Naibedya Chattopadhyay
Keyword(s):  
Bone Regeneration ◽  
Cassia Occidentalis ◽  
Regeneration Effect

Evaluation of a Newly Designed Microperforated Pure Titanium Membrane for Guided Bone Regeneration

2019 ◽  
Vol 34 (2) ◽  
pp. 411-422 ◽  
Author(s):  
Hiroshi Hasegawa ◽  
Seiichiro Masui ◽  
Hiroshi Ishihata ◽  
Tetsuharu Kaneko ◽  
Daichi Ishida ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Pure Titanium ◽  
Guided Bone Regeneration ◽  
Titanium Membrane
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