scholarly journals Effects of unloading by tail suspension on biological apatite crystallite alignment in mouse femur

2020 ◽  
Vol 39 (4) ◽  
pp. 670-677
Author(s):  
Kosuke NAKAJIMA ◽  
Satoru MATSUNAGA ◽  
Toshiyuki MORIOKA ◽  
Takayoshi NAKANO ◽  
Shinichi ABE ◽  
...  
Keyword(s):  
Tail Suspension ◽  
Biological Apatite

Filling TiO2 Nanotubes with Biological Apatite by Alternative Loop Immersion Method

2011 ◽  
Vol 26 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Jia YU ◽  
Xiu-Feng XIAO ◽  
Jian-He LIANG ◽  
Rong-Fang LIU ◽  
Chun-Yan WANG ◽  
...  
Keyword(s):  
Immersion Method ◽  
Biological Apatite

scholarly journals Astaxanthin Prevents Atrophy in Slow Muscle Fibers by Inhibiting Mitochondrial Reactive Oxygen Species via a Mitochondria-Mediated Apoptosis Pathway

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 379
Author(s):  
Luchuanyang Sun ◽  
Nobuyuki Miyaji ◽  
Min Yang ◽  
Edward M. Mills ◽  
Shigeto Taniyama ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Bilayer ◽  
Muscle Atrophy ◽  
Soleus Muscle ◽  
Reactive Oxygen ◽  
H2o2 Production ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Tail Suspension ◽  
Apoptosis Pathway

Astaxanthin (AX) is a carotenoid that exerts potent antioxidant activity and acts in the lipid bilayer. This study aimed to investigate the effects of AX on muscle-atrophy-mediated disturbance of mitochondria, which have a lipid bilayer. Tail suspension was used to establish a muscle-atrophied mouse model. AX diet fed to tail-suspension mice prevented loss of muscle weight, inhibited the decrease of myofiber size, and restrained the increase of hydrogen peroxide (H2O2) production in the soleus muscle. Additionally, AX improved downregulation of mitochondrial respiratory chain complexes I and III in the soleus muscle after tail suspension. Meanwhile, AX promoted mitochondrial biogenesis by upregulating the expressions of adenosine 5′-monophosphate–activated protein kinase (AMPK) α-1, peroxisome proliferator–activated receptor (PPAR)-γ, and creatine kinase in mitochondrial (Ckmt) 2 in the soleus muscle of tail-suspension mice. To confirm the AX phenotype in the soleus muscle, we examined its effects on mitochondria using Sol8 myotubes derived from the soleus muscle. We found that AX was preferentially detected in the mitochondrial fraction; it significantly suppressed mitochondrial reactive oxygen species (ROS) production in Sol8 myotubes. Moreover, AX inhibited the activation of caspase 3 via inhibiting the release of cytochrome c into the cytosol in antimycin A–treated Sol8 myotubes. These results suggested that AX protected the functional stability of mitochondria, alleviated mitochondrial oxidative stress and mitochondria-mediated apoptosis, and thus, prevented muscle atrophy.

scholarly journals Alignment of Biological Apatite Crystallites in Peri-Implant Bone of Beagles

2017 ◽  
Vol 58 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Kento Odaka ◽  
Satoru Matsunaga ◽  
Masaaki Kasahara ◽  
Takayoshi Nakano ◽  
Masao Yoshinari ◽  
...  
Keyword(s):  
Biological Apatite

Osteopontin is associated with nuclear factor κB gene expression during tail-suspension-induced bone loss

2006 ◽  
Vol 312 (16) ◽  
pp. 3075-3083 ◽  
Author(s):  
Muneaki Ishijima ◽  
Yoichi Ezura ◽  
Kunikazu Tsuji ◽  
Susan R. Rittling ◽  
Hisashi Kurosawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Loss ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Tail Suspension

scholarly journals Pattern of c-Fos expression induced by tail suspension test in the mouse brain

Heliyon ◽  
2017 ◽  
Vol 3 (6) ◽  
pp. e00316 ◽  
Author(s):  
Kentaro Hiraoka ◽  
Keisuke Motomura ◽  
Satoru Yanagida ◽  
Ayako Ohashi ◽  
Nozomi Ishisaka-Furuno ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Fos Expression ◽  
Suspension Test

Antidepressant-like Effects of L-theanine in the Forced Swim and Tail Suspension Tests in Mice

2011 ◽  
Vol 25 (11) ◽  
pp. 1636-1639 ◽  
Author(s):  
Cui Yin ◽  
Lingshan Gou ◽  
Yi Liu ◽  
Xiaoxing Yin ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Tail Suspension ◽  
Forced Swim

Nitric oxide mediates the antidepressant-like effect of modafinil in mouse forced swimming and tail suspension tests

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hossein Omidi-Ardali ◽  
Abolfazl Ghasemi Badi ◽  
Elham Saghaei ◽  
Hossein Amini-Khoei
Keyword(s):  
Nitric Oxide ◽  
Effective Dose ◽  
Animal Studies ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Immobility Time ◽  
Swimming Test ◽  
Underlying Mechanisms

AbstractObjectivesPrevious studies have suggested antidepressant properties for modafinil; however, the underlying mechanisms mediating the antidepressant effect of modafinil have not been well recognized in clinical and animal studies. Nitric oxide (NO) is involved in the pathophysiology of depression. We attempted to investigate the possible role of NO in the antidepressant-like effect of modafinil in mouse forced swimming test (FST) and tail suspension test (TST).MethodsThe antidepressant-like effect of modafinil (25, 50 and 75 mg/kg), alone and in combination with l-arginine, l-arg, (100 mg/kg) and NG-l-arginine methyl ester, l-NAME (5 mg/kg), was evaluated using FST and TST. Following behavioral tests, the hippocampi were dissected out to measure nitrite levels.ResultsFindings suggested that administration of modafinil at doses of 50 and 75 mg/kg significantly reduced immobility time in the FST and TST. Furthermore, administration of l-arg and l-NAME increased and decreased, respectively, the immobility time in the FST and TST. We showed that co-administration of a sub-effective dose of modafinil (25 mg/kg) plus l-NAME potentiated the antidepressant-like effect of the sub-effective dose of modafinil. In addition, co-treatment of an effective dose of modafinil (75 mg/kg) with l-arg attenuated the antidepressant-like effect of the effective dose of modafinil. We showed that the antidepressant-like effect of modafinil is associated with decreased nitrite levels in the hippocampus.ConclusionsOur findings for the first time support that the modulation of NO, partially at least, is involved in the antidepressant-like effect of modafinil in mouse FST and TST.

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