Antidepressant-like Effects of L-theanine in the Forced Swim and Tail Suspension Tests in Mice

2011 ◽  
Vol 25 (11) ◽  
pp. 1636-1639 ◽  
Author(s):  
Cui Yin ◽  
Lingshan Gou ◽  
Yi Liu ◽  
Xiaoxing Yin ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Tail Suspension ◽  
Forced Swim

scholarly journals Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

2017 ◽  
Vol 6 (3) ◽  
pp. 695
Author(s):  
Chiranjeevi Bonda ◽  
Sudhir Pawar ◽  
Jaisen Lokhande
Keyword(s):  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Group I ◽  
Immobility Time ◽  
Suspension Test

Background: The aim of the study was to evaluate the antidepressant effect of opioid analgesic tramadol using forced swim test and tail suspension test models.Methods: The antidepressant effect was assessed by recording the immobility time in Forced swim test (FST) and Tail suspension test (TST). The mice were randomly divided into five groups. Mice belonging to group I was given normal saline (0.1ml/kg) which acted as control. Group II received imipramine (15mg/kg) considered as the standard drug tramadol was given in graded dose (10, 20 and 40 mg/kg) to mice of groups III, IV, V respectively. All drugs were administered intraperitoneally for seven successive days; test was done on 7th day.Results: Tramadol and Imipramine showed antidepressant activity when compared to control. There is dose dependent increase in antidepressant activity of tramadol. The antidepressant activity of imipramine was significantly (P<0.05) more than tramadol at dose 10 and 20 mg/kg but antidepressant activity with tramadol 40mg/kg was comparable to imipramine treated mice.Conclusions: The results of this study indicated the presence of antidepressant activity of tramadol at 40mg/kg.

A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests

2005 ◽  
Vol 164 (2) ◽  
pp. 266-269 ◽  
Author(s):  
Michel Bourin ◽  
Franck Chenu ◽  
Nadège Ripoll ◽  
Denis Joseph Paul David
Keyword(s):  
Decision Tree ◽  
Tail Suspension ◽  
Forced Swim

Caffeine augments the antidepressant-like activity of mianserin and agomelatine in forced swim and tail suspension tests in mice

2016 ◽  
Vol 68 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Ewa Poleszak ◽  
Aleksandra Szopa ◽  
Elżbieta Wyska ◽  
Wirginia Kukuła-Koch ◽  
Anna Serefko ◽  
...  
Keyword(s):  
Tail Suspension ◽  
Forced Swim

scholarly journals EFFECT OF FLAVONE AND ITS MONOHYDROXY DERIVATIVES ON ANIMAL MODELS OF DEPRESSION IN SWISS ALBINO MICE

2019 ◽  
pp. 513-517
Author(s):  
SHANMUGAPRIYAN S ◽  
JAIKUMAR S ◽  
VISWANATHAN S ◽  
PARIMALA K ◽  
RAJESH M
Keyword(s):  
Animal Models ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Animal Models Of Depression ◽  
Pre Treatment ◽  
Suspension Test

Objectives: This research was designed to investigate the antidepressant activity of a few structurally related flavones (flavone, 3‑hydroxyflavone, and 7‑hydroxyflavone) and the possible mechanisms involved. Methods: Antidepressant activity was evaluated in mice by subjecting them to forced swim test and tail suspension test. The involvement of adrenergic, serotonergic, nitric oxide (NO), and opioid mechanisms was investigated using suitable interacting chemicals. Results: Flavone, 3‑hydroxyflavone, and 7‑hydroxyflavone exhibited a significant and dose‑dependent reduction in total time of immobility in the forced swim test and tail suspension test. Pre‑treatment with alpha‑methyl‑para‑tyrosine and parachlorophenyl alanine attenuated the reduction in immobility period produced by flavone and its derivatives in forced swim test. Naloxone pre‑treatment partially reversed the effect of flavone while L‑arginine pre‑treatment did not alter their effect. Conclusion: The investigated flavones exhibited promising antidepressant activity in both the animal models of depression. However, the flavone compounds did not alter the motor coordination and ambulatory behavior in the Rotarod and locomotor activity test. The participation of serotonergic, adrenergic, and opioid mechanism in the antidepressant activity of these compounds was elucidated from the results, and the role of NO pathway was excluded.

scholarly journals Attenuating depression behavior by Centella asiatica extract & venlafaxine in mice induced through Forced swim and Tail suspension test

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Vinay Kumar ◽  
Aakanksha Tomar ◽  
Bhulan Kumar Singh ◽  
Kandasamy Nagarajan ◽  
Lalit Machawal ◽  
...  
Keyword(s):  
Centella Asiatica ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Forced Swim ◽  
Suspension Test

scholarly journals Antidepressant-like effect of Cuminum cyminum essential oil on the forced swim and tail suspension tests in male mice

2020 ◽  
Vol 22 (4) ◽  
pp. 167-172
Author(s):  
Kosar Asadi ◽  
Saeid Abbasi-Maleki ◽  
Goudarz Sadeghi Hashjin
Keyword(s):  
Essential Oil ◽  
Biological Activities ◽  
Forced Swim Test ◽  
Gas Chromatography Mass Spectrometry ◽  
Male Mice ◽  
Tail Suspension ◽  
Swimming Time ◽  
Cuminum Cyminum ◽  
Forced Swim ◽  
Immobility Time

Background and aims: Several pharmacological and biological activities have been attributed to Cuminum cyminum L. (CC), including analgesic, antioxidant, anti-inflammatory, and anti-epileptic effects. In this regard, the present study evaluated the antidepressant-like effects of the CC essential oil (EO) on the forced swim test (FST) and tail suspension test (TST) in male mice. Materials and Methods: The gas chromatography-mass spectrometry (GC-MS) apparatus was used for detecting the chemical compounds of CC EO. In the present study, 72 male NMRI mice were randomly allocated to 12 groups (each containing 6 animals) including control or vehicle (10 mL/kg, i.p.), fluoxetine (20 mg/kg, i.p.), imipramine (30 mg/kg, i.p), and the CC EO (100, 200, and 300 mg/kg, i.p.). Then, several parameters were measured and recorded, including immobility time, swimming time, and climbing time in FST, along with immobility time in TST, respectively. Results: Cuminaldehyde followed by cymene, γ-terpinene, phenylglycol, 2-caren-10-al, 2-β-pinene, acoradiene, and cuminic acid were the major components of the CC EO. Based on the results, all doses of the CC, fluoxetine, and imipramine reduced immobility time in both FST (P<0.001) and TST (P<0.001). On the other hand, all doses of the CC and fluoxetine increased swimming time (P<0.001) although climbing time was only increased by 200 and 300 mg/kg of the EO (P<0.01 and P<0.001, respectively) and imipramine (P<0.001). Conclusion: Based on the findings of the present study, the components of the CC induced antidepressant-like activity similar to that of fluoxetine and imipramine in both tests. However, further studies are required to confirm the role of different active components and the exact mechanism of action.

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