scholarly journals De la musique à la lutte armée, de 1968 à Action directe : entretien avec Jean-Marc Rouillan

Transposition ◽  
2020 ◽  
Author(s):  
Luis Velasco-Pufleau
Keyword(s):  
Action Directe

Action directe des antagonistes des minéralocorticoïdes sur la biosynthèse de l'aldostérone : activités comparées de plusieurs nouveaux composés

1983 ◽  
Vol 61 (1) ◽  
pp. 23-28 ◽  
Author(s):  
P. Netchitailo ◽  
I. Perroteau ◽  
C. Delarue ◽  
F. Leboulenger ◽  
M. H. Capron ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
Inhibiting Activity ◽  
Mineralocorticoid Receptors ◽  
Strong Inhibitor ◽  
Aldosterone Antagonists ◽  
Angiotensin System ◽  
Inhibiting Effect ◽  
Spontaneous Production ◽  
Stimulation Of ◽  
Action Directe

Spironolactone is a diuretic steroid which is capable of blocking the binding of aldosterone to its cytosol receptor at the distal convoluted tubule. In addition, it has been shown that spironolactone is a strong inhibitor of steroidogenesis. More recently, new aldosterone antagonists have been discovered. Some of these compounds are more active than spironolactone in competing with aldosterone and have higher specificity for mineralocorticoid receptors. In this study we compare the direct activity of new antimineralocorticoids (SC 23133, SC 19886, SC 26304, and SC 27169) on aldosterone biosynthesis. Marked differences were found in the activity of these compounds upon steroidogenesis. SC 23133 gave rise to a strong inhibiting activity (90%). This activity was reversible (recovery of spontaneous production occurs 150 min after the end of the administration of SC 23133). SC 19886 totally inhibited aldosterone biosynthesis (95%) in a lasting mean. Conversely, SC 27169 and SC 26304 presented no or weak inhibiting effect. Further experiments showed that SC 27169 was unable to block the stimulation of aldosterone biosynthesis induced by corticotropic peptides, whereas the administration of SC 23133 and SC 19886 totally suppressed the stimulatory effect of ACTH and angiotensin II. Owing to the important stimulation of the renin–angiotensin system induced by antimineralocorticoid treatment, these results suggest that SC 23133 and SC 19886 will exert a higher antinatriuretic activity than SC 27169.

Bénéfice des antiviraux à action directe chez les patients VHC mono-infectés ou co-infectés VIH-VHC ayant une cryoglobulinémie mixte

2017 ◽  
Vol 47 (4) ◽  
pp. S72
Author(s):  
M. Diakite ◽  
P. Miailhes ◽  
K. Hartig-lavie ◽  
P. Pradat ◽  
C. Chidiac ◽  
...  
Keyword(s):  
Action Directe

HEP-14 - Caractéristiques des patients en échec de traitement par combinaisons d’antiviraux à action directe (AAD) chez les patients co-infectés VIH/VHC

2016 ◽  
Vol 46 (4) ◽  
pp. 55
Author(s):  
D. Salmon ◽  
C. Gilbert ◽  
E. Rosenthal ◽  
P. Miailhes ◽  
J. Chas ◽  
...  
Keyword(s):  
Action Directe
Sign in / Sign up

Export Citation Format

Share Document