scholarly journals Notes of MRI based indication for intravenous rt-PA: Significance of reversed discrepancy and deep white matter lesion

Nosotchu ◽  
2009 ◽  
Vol 31 (5) ◽  
pp. 349-355
Author(s):  
Teruyuki Hirano
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Deep White Matter

INCREASED RISK FOR SILENT BRAIN INFARCTION AND DEEP WHITE MATTER LESION IN ALCOHOLIC PATIENTS.

2004 ◽  
Vol 28 (Supplement) ◽  
pp. 22A
Author(s):  
Sachio Matsushita ◽  
Go Suzuki ◽  
Toshifumi Matsui ◽  
Toshihiro Masaki ◽  
Hiroyuki Arai ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Brain Infarction ◽  
Deep White Matter ◽  
Increased Risk ◽  
Silent Brain Infarction

Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy

2020 ◽  
Vol 40 (3) ◽  
pp. 287-294 ◽  
Author(s):  
Akira Arakawa ◽  
Yuko Saito ◽  
Tomonari Seki ◽  
Akihiko Mitsutake ◽  
Tatsuya Sato ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Corticobasal Degeneration ◽  
Brain Biopsy ◽  
Deep White Matter

Abstract 110: Age Associated Brain Volume is More Closely Correlated to Periventricular than Deep White Matter Disease

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Paul Nyquist ◽  
Murat Bilgel ◽  
Lisa R Yanek ◽  
Taryn F Moy ◽  
Lewis C Becker ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Volume ◽  
White Matter Lesion ◽  
Older Age ◽  
Periventricular White Matter ◽  
Premature Coronary Artery Disease ◽  
Lesion Volume ◽  
Intracranial Volume ◽  
Total Brain Volume ◽  
Deep White Matter

Introduction: The loss of total brain volume (TBV) due to aging is associated with increasing ischemic white matter lesion volume (WMH) and dementia. Lower TBV may be secondary to chronic ischemia and hypoperfusion throughout the periventricular white matter rather than the burden of focal ischemia in the deep white matter. We hypothesized lower TBV would be more closely correlated with increasing periventricular white matter lesion volume (PV) rather than deep white matter lesion volume (DWMH). Methods: We enrolled 593 asymptomatic family members of probands with premature coronary artery disease (<60 years). DWMH, PV, and TBV were measured with 3Tesla MRI. Multivariate regression was completed for DWMH, PV, and TBV using volume change per age decade controlling for sex, race, diabetes, smoking currently, hypertension, obesity , and intracranial volume (ICV) for TBV, and a spline incorporated at age 54. Results: Participants were 58% women, 37% African-American, 29-74 years old. TBV/ICV was more correlated to PV than DWMH (correlation coefficients -0.26 and -0.11, p=<0.001 and 0.006). The PV was greater with older age 9%/decade until age 54 (95% CI 4-15%) and 24%/decade after age 54 (95% CI 1.6-3.2%). TBV was reduced with older age: 1.1 % smaller/decade until age 54 (95% CI -0.6 to -1.6) and 2.4% smaller/decade after (95% CI -1.6 to -3.1). For PV and TBV their age association changed significantly after age 54 (p=0.012, and 0.014). DWMH age association remained constant regardless of age. Conclusions: PV is more strongly correlated to TBV than DWMH and the age associated changes in PV and TBV were more similar to one another than DWMH. The association of increasing PV with lower TBV may help to explain the association of cognitive and motor decline with increasing PV. Future longitudinal studies are needed to verify this association.

A fetal circle of Willis is associated with a decreased deep white matter lesion load

Neurology ◽  
2005 ◽  
Vol 64 (12) ◽  
pp. 2163-2164 ◽  
Author(s):  
K. Ikeda ◽  
H. Kashihara ◽  
K. -i Hosozawa ◽  
M. Shimoma ◽  
Y. Ichikawa ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Circle Of Willis ◽  
Lesion Load ◽  
Deep White Matter

A fetal circle of Willis is associated with a decreased deep white matter lesion load

Neurology ◽  
2004 ◽  
Vol 63 (8) ◽  
pp. 1452-1456 ◽  
Author(s):  
J. van der Grond ◽  
A. F. van Raamt ◽  
Y. van der Graaf ◽  
W. P.T.M. Mali ◽  
R. H.C. Bisschops
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Circle Of Willis ◽  
Lesion Load ◽  
Deep White Matter

scholarly journals Transcortical sensory aphasia due to deep white matter lesion of the left frontal lobe.

1997 ◽  
Vol 17 (2) ◽  
pp. 178-184 ◽  
Author(s):  
Nobuyoshi Takahashi ◽  
Mitsuru Kawamura ◽  
Iku Moroo ◽  
Toshiomi Asahi
Keyword(s):  
White Matter ◽  
Frontal Lobe ◽  
White Matter Lesion ◽  
Left Frontal Lobe ◽  
Deep White Matter ◽  
Sensory Aphasia

White Matter Lesion Burden and Depressive Symptoms in MCI Subtypes

2010 ◽  
Author(s):  
Lisa M. Delano-Wood ◽  
Norman Abeles ◽  
Mark W. Bondi ◽  
David J. Libon ◽  
Melissa Lamar ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
White Matter ◽  
White Matter Lesion

Ginkgolide B promotes oligodendrocyte precursor cell differentiation and survival via Akt/CREB/bcl-2 signaling pathway after white matter lesion

2021 ◽  
pp. 153537022198995
Author(s):  
Jian Huang ◽  
Jun Yang ◽  
Xingju Zou ◽  
Shilun Zuo ◽  
Jing Wang ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Neuroprotective Effect ◽  
Precursor Cell ◽  
Cerebral Hypoperfusion ◽  
Ginkgolide B ◽  
Oligodendrocyte Precursor Cell ◽  
Learning Abilities ◽  
Phosphorylated Akt ◽  
Oligodendrocyte Precursor

White matter lesion (WML) is caused by chronic cerebral hypoperfusion, which are usually associated with cognitive impairment. Evidence from recent studies has shown that ginkgolide B has a neuroprotective effect that could be beneficial for the treatment of ischemia; however, it is not clear whether ginkgolide B has a protective effect on WML. Our data show that ginkgolide B can promote the differentiation of oligodendrocyte precursor cell (OPC) into oligodendrocytes and promote oligodendrocyte survival following a WML. Ginkgolide B (5, 10, 20 mg/kg) or saline is administered intraperitoneally every day after WML. After 4 weeks, the data of Morris water maze suggested that rats’ memory and learning abilities were impaired, and the administration of ginkgolide B enhanced behavioral achievement. Also, treatment with ginkgolide B significantly attenuated this loss of myelin. Our result suggests that ginkgolide B promotes the differentiation of OPC into oligodendrocytes. We also found that ginkgolide B ameliorates oligodendrocytes apoptosis. Furthermore, ginkgolide B enhanced the expression of phosphorylated Akt and CREB. In conclusion, our data firstly show that ginkgolide B promotes oligodendrocyte genesis and oligodendrocyte myelin following a WML, possibly involving the Akt and CREB pathways.

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