Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy

2020 ◽  
Vol 40 (3) ◽  
pp. 287-294 ◽  
Author(s):  
Akira Arakawa ◽  
Yuko Saito ◽  
Tomonari Seki ◽  
Akihiko Mitsutake ◽  
Tatsuya Sato ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Corticobasal Degeneration ◽  
Brain Biopsy ◽  
Deep White Matter

INCREASED RISK FOR SILENT BRAIN INFARCTION AND DEEP WHITE MATTER LESION IN ALCOHOLIC PATIENTS.

2004 ◽  
Vol 28 (Supplement) ◽  
pp. 22A
Author(s):  
Sachio Matsushita ◽  
Go Suzuki ◽  
Toshifumi Matsui ◽  
Toshihiro Masaki ◽  
Hiroyuki Arai ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Brain Infarction ◽  
Deep White Matter ◽  
Increased Risk ◽  
Silent Brain Infarction

Abstract 110: Age Associated Brain Volume is More Closely Correlated to Periventricular than Deep White Matter Disease

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Paul Nyquist ◽  
Murat Bilgel ◽  
Lisa R Yanek ◽  
Taryn F Moy ◽  
Lewis C Becker ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Volume ◽  
White Matter Lesion ◽  
Older Age ◽  
Periventricular White Matter ◽  
Premature Coronary Artery Disease ◽  
Lesion Volume ◽  
Intracranial Volume ◽  
Total Brain Volume ◽  
Deep White Matter

Introduction: The loss of total brain volume (TBV) due to aging is associated with increasing ischemic white matter lesion volume (WMH) and dementia. Lower TBV may be secondary to chronic ischemia and hypoperfusion throughout the periventricular white matter rather than the burden of focal ischemia in the deep white matter. We hypothesized lower TBV would be more closely correlated with increasing periventricular white matter lesion volume (PV) rather than deep white matter lesion volume (DWMH). Methods: We enrolled 593 asymptomatic family members of probands with premature coronary artery disease (<60 years). DWMH, PV, and TBV were measured with 3Tesla MRI. Multivariate regression was completed for DWMH, PV, and TBV using volume change per age decade controlling for sex, race, diabetes, smoking currently, hypertension, obesity , and intracranial volume (ICV) for TBV, and a spline incorporated at age 54. Results: Participants were 58% women, 37% African-American, 29-74 years old. TBV/ICV was more correlated to PV than DWMH (correlation coefficients -0.26 and -0.11, p=<0.001 and 0.006). The PV was greater with older age 9%/decade until age 54 (95% CI 4-15%) and 24%/decade after age 54 (95% CI 1.6-3.2%). TBV was reduced with older age: 1.1 % smaller/decade until age 54 (95% CI -0.6 to -1.6) and 2.4% smaller/decade after (95% CI -1.6 to -3.1). For PV and TBV their age association changed significantly after age 54 (p=0.012, and 0.014). DWMH age association remained constant regardless of age. Conclusions: PV is more strongly correlated to TBV than DWMH and the age associated changes in PV and TBV were more similar to one another than DWMH. The association of increasing PV with lower TBV may help to explain the association of cognitive and motor decline with increasing PV. Future longitudinal studies are needed to verify this association.

A fetal circle of Willis is associated with a decreased deep white matter lesion load

Neurology ◽  
2005 ◽  
Vol 64 (12) ◽  
pp. 2163-2164 ◽  
Author(s):  
K. Ikeda ◽  
H. Kashihara ◽  
K. -i Hosozawa ◽  
M. Shimoma ◽  
Y. Ichikawa ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Circle Of Willis ◽  
Lesion Load ◽  
Deep White Matter

scholarly journals Treatable Leukoencephalopathy in a Patient with Hypophosphatemia

2017 ◽  
Vol 8 (3) ◽  
pp. 264-271 ◽  
Author(s):  
Masahiro Okazaki ◽  
Makito Hirano ◽  
Tomoki Iwatsu ◽  
Masaki Yamana ◽  
Hidekazu Suzuki ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Biopsy ◽  
Extrapontine Myelinolysis ◽  
Deep White Matter ◽  
Central Pontine ◽  
Osmotic Myelinolysis ◽  
First Diagnosis

We report the first patient with pathologically proven leukoencephalopathy associated with hypophosphatemia. A 61-year-old woman had repetitive episodes of decreased consciousness with pontine and pallidal lesions and extensive leukoencephalopathy on MRI, later found to be associated with hypophosphatemia. Although hypophosphatemia has been linked to central pontine and extrapontine myelinolysis (osmotic myelinolysis), lesions in the deep white matter have not been reported. Brain biopsy performed during the first diagnosis process revealed nonspecific demyelination with gliosis, a finding similar to that of chronic osmotic myelinolysis. After normalization of phosphate levels, her consciousness completely improved and MRI abnormalities partly resolved. We should consider that leukoencephalopathy can be associated with hypophosphatemia, which is often treatable.

A fetal circle of Willis is associated with a decreased deep white matter lesion load

Neurology ◽  
2004 ◽  
Vol 63 (8) ◽  
pp. 1452-1456 ◽  
Author(s):  
J. van der Grond ◽  
A. F. van Raamt ◽  
Y. van der Graaf ◽  
W. P.T.M. Mali ◽  
R. H.C. Bisschops
Keyword(s):  
White Matter ◽  
White Matter Lesion ◽  
Circle Of Willis ◽  
Lesion Load ◽  
Deep White Matter

scholarly journals Transcortical sensory aphasia due to deep white matter lesion of the left frontal lobe.

1997 ◽  
Vol 17 (2) ◽  
pp. 178-184 ◽  
Author(s):  
Nobuyoshi Takahashi ◽  
Mitsuru Kawamura ◽  
Iku Moroo ◽  
Toshiomi Asahi
Keyword(s):  
White Matter ◽  
Frontal Lobe ◽  
White Matter Lesion ◽  
Left Frontal Lobe ◽  
Deep White Matter ◽  
Sensory Aphasia

White Matter Lesion Burden and Depressive Symptoms in MCI Subtypes

2010 ◽  
Author(s):  
Lisa M. Delano-Wood ◽  
Norman Abeles ◽  
Mark W. Bondi ◽  
David J. Libon ◽  
Melissa Lamar ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
White Matter ◽  
White Matter Lesion
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