Pseudoesters and Derivatives. XXVIII. The Reaction of 5-Methoxy-3-pyrrolin-2-one and Its 3-Bromo Derivative with Nitrogen and Sulphur Nucleophiles

Heterocycles ◽  
1988 ◽  
Vol 27 (1) ◽  
pp. 173 ◽  
Author(s):  
Francisco Fariña ◽  
M. Dolores Jim始ez ◽  
Raquel Ortega ◽  
Amelia Tito
Keyword(s):  
Bromo Derivative

Synthesis of 17β-[4-(1,3-thiazolyl)]androstane 3β-hemisuccinate and glycoside

1984 ◽  
Vol 49 (4) ◽  
pp. 1039-1050 ◽  
Author(s):  
Pavel Drašar ◽  
Vladimír Pouzar ◽  
Ivan Černý ◽  
Jorga Smolíková ◽  
Miroslav Havel
Keyword(s):  
Osmium Tetroxide ◽  
Hydroxy Ketone ◽  
Hantzsch Reaction ◽  
Bromo Derivative

The protected 20(21)-en-20-ol ether III was oxidized with N-methylmorpholine N-oxide monohydrate and osmium tetroxide to give the hydroxy ketone IV which was converted into the bromo derivative VIII via the mesylate VI. Hantzsch reaction of the bromo ketone VIII with ethyl thioxamate afforded the thiazole XI whose hemisuccinate XIII and glycoside XV were prepared.

Reactivity of Sodium Hexaethyl-2,4-dicarba-nido-hexaborate(1-)

1999 ◽  
Vol 64 (6) ◽  
pp. 977-985 ◽  
Author(s):  
Bernd Wrackmeyer ◽  
Hans-Jörg Schanz ◽  
Wolfgang Milius ◽  
Catherine McCammon
Keyword(s):  
Mössbauer Spectroscopy ◽  
Nmr Spectroscopy ◽  
Structural Analysis ◽  
Hydrogen Atom ◽  
Mossbauer Spectroscopy ◽  
Sandwich Complex ◽  
X Ray ◽  
Bromo Derivative ◽  
Boron Tribromide ◽  
C Nmr

Sodium hexaethyl-2,4-dicarba-nido-hexaborate(1-) (6), available from hexaethyl-2,4-dicarba- nido-hexaborane(8) (4) by deprotonation, reacts with deuterated methanol, CD3OD, to give back 4 without H/D exchange of the B-H-B hydrogen atom. The reaction of 6 with diethylboron chloride, Et2BCl, affords hexaethyl-2,4-dicarba-closo-hexaborane(6) (7), the first example of a peralkylated carborane of this type. In contrast, the reaction of 6 with boron tribromide, BBr3, leads mainly to 2,3,4,5,6,7-hexaethyl-2,4-dicarba-closo-heptaborane(7) (8), together with the corresponding 1-bromo derivative (9) and the closo-carborane 7 as side products. The reaction of two equivalents of 6 with FeCl2 gives the air-stable sandwich complex bis[hexaethyl-2,4-dicarba-nido-hexaborate(1-)]iron 10 which was characterised by X-ray structural analysis. All products were characterised by 1H, 11B and 13C NMR spectroscopy, and 57Fe Mössbauer spectroscopy was used to study 10.

Synthesis and Crystal Structures of the P,N-Substituted Ferrocenes [Fe{η5-C5H4–P(S)Ph2}(η5-C5H4–NHCH2tBu)] and [Fe(η5-C5H4– PPh2)(η5-C5H4–NHCH2tBu)]

2014 ◽  
Vol 69 (8) ◽  
pp. 906-912 ◽  
Author(s):  
Michael Ritte ◽  
Clemens Bruhn ◽  
Ulrich Siemeling
Keyword(s):  
Crystal Structures ◽  
Raney Nickel ◽  
X Ray Diffraction ◽  
X Ray ◽  
Bromo Derivative

The P,N-substituted ferrocene [Fe{η5-C5H4-P(S)Ph2}(η5-C5H4-NHCH2tBu)] was prepared in six steps from the bromo derivative [Fe{η5-C5H4-PPh2}(η5-C5H4-Br)]. Its reductive desulfurisation with Raney nickel afforded the corresponding phosphino-substituted derivative [Fe(η5-C5H4- PPh2)(η5-C5H4-NHCH2tBu)]. Both compounds have been structurally characterised by singlecrystal X-ray diffraction studies.

scholarly journals Solution speciation of potential anticancer metal complexes of salicylaldehyde semicarbazone and its bromo derivative

Polyhedron ◽  
2014 ◽  
Vol 67 ◽  
pp. 242-252 ◽  
Author(s):  
Éva A. Enyedy ◽  
Gabriella M. Bognár ◽  
Nóra V. Nagy ◽  
Tamás Jakusch ◽  
Tamás Kiss ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Bromo Derivative ◽  
Solution Speciation

ChemInform Abstract: SYNTHESIS OF 3,5,7-CYCLOOCTATRIENE-1,2-DIONE AND ITS 3-BROMO DERIVATIVE

1978 ◽  
Vol 9 (5) ◽  
Author(s):  
MASAGI ODA ◽  
MITSUNORI ODA ◽  
S. MIYAKOSHI ◽  
Y. KITAHARA
Keyword(s):  
Bromo Derivative

ChemInform Abstract: RELATIONSHIP BETWEEN METABOLISM AND RADIOPROTECTIVE ACTIVITY OF 2-PHENYLTHIAZOLIDINE AND ITS M-BROMO DERIVATIVE

1984 ◽  
Vol 15 (6) ◽  
Author(s):  
J. P. FERNANDEZ ◽  
Y. ROBBE ◽  
J. P. CHAPAT ◽  
J. L. CHANAL ◽  
M. GENIN ◽  
...  
Keyword(s):  
Radioprotective Activity ◽  
Bromo Derivative

Relationship between metabolism and radioprotective activity of 2-phenylthiazolidine and its m-bromo derivative

1983 ◽  
Vol 26 (9) ◽  
pp. 1317-1319 ◽  
Author(s):  
J. P. Fernandez ◽  
Y. Robbe ◽  
J. P. Chapat ◽  
J. L. Chanal ◽  
M. Genin ◽  
...  
Keyword(s):  
Radioprotective Activity ◽  
Bromo Derivative

Synthesis of analogues of GABA. V. trans and cis Isomers of some 4-amino-3-halogenobut-2-enoic acids

1980 ◽  
Vol 33 (5) ◽  
pp. 1115 ◽  
Author(s):  
RD Allan ◽  
GAR Johnston ◽  
B Twitchin
Keyword(s):  
Spectral Data ◽  
Specific Activity ◽  
High Specific Activity ◽  
Enoic Acid ◽  
Trans Isomers ◽  
Gaba Transaminase ◽  
Bromo Derivative ◽  
Irreversible Inhibitors ◽  
Convenient Preparation ◽  
Trans Addition

Both trans and cis isomers of 4-amino-3-halogenobut-2-enoic acid have been prepared as potential irreversible inhibitors of the enzyme GABA- transaminase. trans-Addition of HX to 4-chlorobut-2-ynoic acid and subsequent amination gave the trans isomers (2; X = Cl, Br, I), while the key step in the synthesis of the cis isomers (3; X = Cl, Br) was the isomerization to cis-4-bromo-3-halogenobut-2-enoic acids during allylic bromination. The stereochemical assignments are supported by 1H and 13C n.m.r. spectral data. A convenient preparation of cis-4- aminobut-2-enoic acid by reduction of the bromo derivative is described, as well as the synthesis of 4-phthalimidobut-2-ynoic acid which is suitable for preparing radiolabelled GABA of high specific activity.

The Synthesis of Zinquin Ester and Zinquin Acid, Zinc(II)-Specific Fluorescing Agents for Use in the Study of Biological Zinc(II)

1996 ◽  
Vol 49 (5) ◽  
pp. 561 ◽  
Author(s):  
IB Mahadevan ◽  
MC Kimber ◽  
SF Lincoln ◽  
ERT Tiekink ◽  
AD Ward ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Crystal Structures ◽  
Electrophilic Substitution ◽  
Ethyl Acrylate ◽  
Heck Coupling ◽  
Ethyl Bromoacetate ◽  
Reaction Conditions ◽  
Bromo Derivative ◽  
Boron Tribromide

The syntheses of Zinquin ester [ethyl [2-methyl-8-(p- tolylsulfonylamino )-6-quinolyloxy]acetate] and the corresponding acid, both of which are zinc(II)-specific fluorophores , are described. 6-Methoxy-2-methyl-8-(p- tolylsulfonylamino ) quinoline (2) can be demethylated , with boron tribromide, to form either the expected phenol or a mixture of the phenol and the corresponding 5-bromo derivative depending upon the reaction conditions. These compounds react with ethyl bromoacetate to give the corresponding esters, as well as the 5-ethoxycarbonyl derivative formed by electrophilic substitution. Halogenation of the sulfonamide (2) occurs readily at the 5-position. The 5-iodo product undergoes a Heck coupling with ethyl acrylate . The crystal structures of ethyl [5-ethoxycarbonylmethyl-2-methyl-8-(p- tolylsulfonylamino )-6-quinolyloxy]acetate and [5-carboxymethyl-2-methyl-8-(p- tolylsulfonylamino )-6-quinolyloxy]acetic acid are described.

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