Biological Evaluation and Synthesis of Thiazole Schiff Base Derivatives

Heterocycles ◽  
2021 ◽  
Vol 102 (7) ◽  
pp. 1337
Author(s):  
Jinbing Liu ◽  
Wei Zhou ◽  
Fengyan Wu
Keyword(s):  
Schiff Base ◽  
Biological Evaluation ◽  
Schiff Base Derivatives

Synthesis and Biological Evaluation of 3-thiazolocoumarinyl Schiff-base Derivatives as Cholinesterase Inhibitors

2012 ◽  
Vol 80 (4) ◽  
pp. 605-615 ◽  
Author(s):  
Rabia Raza ◽  
Aamer Saeed ◽  
Mubeen Arif ◽  
Shamsul Mahmood ◽  
Muhammad Muddassar ◽  
...  
Keyword(s):  
Schiff Base ◽  
Cholinesterase Inhibitors ◽  
Biological Evaluation ◽  
Schiff Base Derivatives ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Sanjiv Kumar ◽  
Siong Meng Lim ◽  
Kalavathy Ramasamy ◽  
Mani Vasudevan ◽  
Syed Adnan Ali Shah ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Biological Evaluation ◽  
Schiff Base Derivatives

scholarly journals Synthesis and biological evaluation of some pyrazolone based Schiff base derivatives as enzymes inhibitors, antioxidant, and anticancer agents

2021 ◽  
Author(s):  
Ercan ÇINAR ◽  
Eyüp BAŞARAN ◽  
Ömer ERDOĞAN ◽  
Reşit ÇAKMAK ◽  
Mehmet BOĞA ◽  
...  
Keyword(s):  
Schiff Base ◽  
Radical Scavenging ◽  
Cation Radical ◽  
Biological Evaluation ◽  
Normal Fibroblast ◽  
Cytotoxic Activities ◽  
Active Molecule ◽  
Schiff Base Derivatives ◽  
Target Molecules ◽  
Inhibitory Activities

Abstract Drugs with sufficient efficacy for use in the therapy of Alzheimer and other diseases caused by oxidative stress have not yet been produced until today despite the great efforts. Therefore, many people all over the world are experiencing serious health problems due to these diseases nowadays. In the current study, a series of pyrazolone based Schiff base derivatives (2a-e) (except 2a) as target molecules were successfully synthesized for the first time, and then structurally illuminated by using FT-IR, 1H NMR and 13C NMR. Their inhibition activities on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase enzymes were extensively tested, respectively. Furthermore, the synthesized molecules were also investigated for antioxidant and anticancer activities. The potential in vitro cytotoxic activities of the title molecules were examined on HeLa cancer and 3T3 mouse normal fibroblast cell lines using MTT assay. Our results showed that 1b (IC50: 9.497 mM) and 2a (IC50: 30.49 mM) significantly decreased the proliferation of HeLa cells. On the other hand, the apoptotic effect of 1b and 2a were investigated with acridine orange/propidium iodide double staining. The apoptotic cell ratios of the molecules treated with 1b and 2a were determined as 60 and 64%, respectively. While 2b was found to be a very active molecule in antioxidant activities assays in ABTS cation radical scavenging (IC50:17.95±0.47 mM) and CUPRAC (A0.5:48.73±0.52 mM) activities, 2c had a very active molecule in AChE, BChE and tyrosinase inhibitory activities with 82.79±1.03, 91.39±1.06 and 92.60±1.80 inhibition%, respectively. Also, the target molecules (2a-e) showed better antioxidant and enzyme inhibitory activities than those of ester derivatives (1a-e).

scholarly journals Synthesis and Biological Evaluation of Three New Chitosan Schiff Base Derivatives

ACS Omega ◽  
2020 ◽  
Vol 5 (23) ◽  
pp. 13948-13954
Author(s):  
Nadia Q. Haj ◽  
Mohsin O. Mohammed ◽  
Luqman E. Mohammood
Keyword(s):  
Schiff Base ◽  
Biological Evaluation ◽  
Schiff Base Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Chitosan Schiff Base
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