Development of Near-Infrared Fluorescent Probes with Large Stokes Shifts for Non-Invasive Imaging of Tumor Hypoxia

Heterocycles ◽  
2020 ◽  
Vol 101 (2) ◽  
pp. 559
Author(s):  
Hideko Nagasawa ◽  
Kensuke Okuda ◽  
Bahaa G. M. Youssif ◽  
Ryosuke Sakai ◽  
Takahiro Ueno ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Tumor Hypoxia ◽  
Non Invasive ◽  
Stokes Shifts

New Far-red and Near-infrared Fluorescent Probes with Large Stokes Shifts for Dual Covalent Labeling of DNA

2010 ◽  
Vol 5 (8) ◽  
pp. 1761-1764 ◽  
Author(s):  
Thomas Ehrenschwender ◽  
Balázs R. Varga ◽  
Péter Kele ◽  
Hans-Achim Wagenknecht
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Covalent Labeling ◽  
Stokes Shifts

A lysosome-specific near-infrared fluorescent probe for in vitro cancer cell detection and non-invasive in vivo imaging

2019 ◽  
Vol 55 (94) ◽  
pp. 14182-14185 ◽  
Author(s):  
Rakesh Mengji ◽  
Chiranjit Acharya ◽  
Venugopal Vangala ◽  
Avijit Jana
Keyword(s):  
Clinical Practice ◽  
Fluorescent Probe ◽  
Fluorescent Probes ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Cell Detection ◽  
Non Invasive ◽  
Cancer Cell Detection

Near-infrared (NIR) fluorescent probes have been developed as potential bio-materials having profound applications in diagnosis and clinical practice.

scholarly journals Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells

ACS Sensors ◽  
2016 ◽  
Vol 1 (12) ◽  
pp. 1408-1415 ◽  
Author(s):  
Shuwei Zhang ◽  
Rashmi Adhikari ◽  
Mingxi Fang ◽  
Nethaniah Dorh ◽  
Cong Li ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Living Cells ◽  
Stokes Shifts

scholarly journals Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Howard Y. Park ◽  
Stephen D. Zoller ◽  
Vishal Hegde ◽  
William Sheppard ◽  
Zachary Burke ◽  
...  
Keyword(s):  
Real Time ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
Image Guided Surgery ◽  
Fluorescence Image ◽  
Guided Surgery ◽  
Non Invasive ◽  
Image Guided ◽  
Infecting Organisms

AbstractImplant-associated infections are challenging to diagnose and treat. Fluorescent probes have been heralded as a technologic advancement that can improve our ability to non-invasively identify infecting organisms, as well as guide the inexact procedure of surgical debridement. This study’s purpose was to compare two fluorescent probes for their ability to localize Staphylococcus aureus biofilm infections on spinal implants utilizing noninvasive optical imaging, then assessing the broader applicability of the more successful probe in other infection animal models. This was followed by real-time, fluorescence image-guided surgery to facilitate debridement of infected tissue. The two probe candidates, a labelled antibiotic that targets peptidoglycan (Vanco-800CW), and the other, a labelled antibody targeting the immunodominant Staphylococcal antigen A (1D9-680), were injected into mice with spine implant infections. Mice were then imaged noninvasively with near infrared fluorescent imaging at wavelengths corresponding to the two probe candidates. Both probes localized to the infection, with the 1D9-680 probe showing greater fidelity over time. The 1D9-680 probe was then tested in mouse models of shoulder implant and allograft infection, demonstrating its broader applicability. Finally, an image-guided surgery system which superimposes fluorescent signals over analog, real-time, tissue images was employed to facilitate debridement of fluorescent-labelled bacteria.

Near-infrared Inorganic Nanomaterials-based Nanosystem for Photothermal Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Yufei Wang ◽  
Hongmin Meng ◽  
Zhaohui Li
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Strong Absorption ◽  
Non Invasive ◽  
Inorganic Nanomaterials

The development of robust materials for treating diseases through non-invasive photothermal therapy (PTT) has attracted increasing attention in recent years. Among many types of nanomaterials, inorganic nanomaterials with strong absorption...

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