AlCl3-Promoted Cyclization of β-Keto Derivatives with in situ Generated Enamines under Solvent-Free High Speed Ball Milling: An Efficient One-Pot Access to Polysubstituted 1,4-Dihydropyridines

Heterocycles ◽  
2017 ◽  
Vol 94 (11) ◽  
pp. 2054 ◽  
Author(s):  
Ze Zhang ◽  
Ji-Chao Zeng ◽  
Fei Yu ◽  
Abdullah M. Asiri ◽  
Hadi M. Marwani
Keyword(s):  
Ball Milling ◽  
High Speed ◽  
Solvent Free ◽  
One Pot ◽  
High Speed Ball Milling

Solvent-free Sonogashira coupling reaction via high speed ball milling

2009 ◽  
Vol 11 (11) ◽  
pp. 1821 ◽  
Author(s):  
Dennis A. Fulmer ◽  
William C. Shearouse ◽  
Shareika T. Medonza ◽  
James Mack
Keyword(s):  
Ball Milling ◽  
High Speed ◽  
Coupling Reaction ◽  
Solvent Free ◽  
Sonogashira Coupling ◽  
Sonogashira Coupling Reaction ◽  
High Speed Ball Milling

ChemInform Abstract: Making Kinetic and Thermodynamic Enolates via Solvent-Free High Speed Ball Milling.

ChemInform ◽  
2010 ◽  
Vol 41 (26) ◽  
pp. no-no
Author(s):  
Daniel C. Waddell ◽  
Indre Thiel ◽  
Tammara D. Clark ◽  
S. Tyler Marcum ◽  
James Mack
Keyword(s):  
Ball Milling ◽  
High Speed ◽  
Solvent Free ◽  
High Speed Ball Milling

Solvent-free accelerated organic syntheses using microwaves

2001 ◽  
Vol 73 (1) ◽  
pp. 193-198 ◽  
Author(s):  
Rajender S. Varma
Keyword(s):  
Organic Synthesis ◽  
High Speed ◽  
Multicomponent Reactions ◽  
Solvent Free ◽  
Parallel Synthesis ◽  
One Pot ◽  
Reduction Reactions ◽  
Heterocyclic Molecules ◽  
Organic Syntheses

A solvent-free approach for organic synthesis is described which involves microwave (MW) exposure of neat reactants (undiluted) either in the presence of a catalyst or catalyzed by the surfaces of inexpensive and recyclable mineral supports such as alumina, silica, clay, or "doped" surfaces, namely, Fe(NO3)3-clay (clayfen), Cu(NO3)2-clay (claycop), NH2OH-clay, PhI(OAc)2-alumina, NaIO4-silica, MnO2-silica, and NaBH4-clay. A variety of deprotection, condensation, cyclization, oxidation, and reduction reactions are presented including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates such as enamines and a-tosyloxyketones. The application of this solvent-free MW approach to multicomponent reactions is highlighted that can be adapted for high-speed parallel synthesis of the library of dihydropyrimidine-2(1H)-ones and imidazo [1,2-a]annulated pyridines, pyrazines, and pyrimidines.

ChemInform Abstract: Solvent-Free Sonogashira Coupling Reaction via High Speed Ball Milling.

ChemInform ◽  
2010 ◽  
Vol 41 (12) ◽  
Author(s):  
Dennis A. Fulmer ◽  
William C. Shearouse ◽  
Shareika T. Medonza ◽  
James Mack
Keyword(s):  
Ball Milling ◽  
High Speed ◽  
Coupling Reaction ◽  
Solvent Free ◽  
Sonogashira Coupling ◽  
Sonogashira Coupling Reaction ◽  
High Speed Ball Milling

Making kinetic and thermodynamic enolates via solvent-free high speed ball milling

2010 ◽  
Vol 12 (2) ◽  
pp. 209-211 ◽  
Author(s):  
Daniel C. Waddell ◽  
Indre Thiel ◽  
Tammara D. Clark ◽  
S. Tyler Marcum ◽  
James Mack
Keyword(s):  
Ball Milling ◽  
High Speed ◽  
Solvent Free ◽  
High Speed Ball Milling

scholarly journals Mechanochemical sulfonation of aromatic compounds using NaHSO4·H2O/P2O5

2021 ◽  
pp. 174751982110325
Author(s):  
Lu-Lu Zuo ◽  
Shuai Qin ◽  
Pu Zhang ◽  
Yu-Jun Qin ◽  
Zhi-Xin Guo
Keyword(s):  
Ball Milling ◽  
Aromatic Compounds ◽  
High Speed ◽  
Sulfonic Acids ◽  
High Speed Ball Milling

A series of aromatic sulfonic acids is synthesized by subjecting arenes and NaHSO4·H2O to high-speed ball milling in the presence of P2O5. It is suggested the aromatic sulfonation occurs via in situ generated H2SO4 to give aromatic sulfonic acids. In some cases, formation of diaryl sulfones was observed.

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