Ultrasound Promoted Efficient Construction of Polycyclic-Fused Pyrazolo[4,3-c]pyridines via Domino Reaction

Heterocycles ◽  
2017 ◽  
Vol 94 (10) ◽  
pp. 1958 ◽  
Author(s):  
Dao-Lin Wang ◽  
Jiao Xu ◽  
Ting Zhou ◽  
Liang Yan ◽  
Wei Ma
Keyword(s):  
Domino Reaction ◽  
Efficient Construction

Highly efficient construction of pentacyclic benzo[b]indeno-[1,2,3-de][1,8]naphthyridine derivatives via four-component domino reaction

2013 ◽  
Vol 49 (62) ◽  
pp. 6983 ◽  
Author(s):  
Cheng-Pao Cao ◽  
Wei Lin ◽  
Ming-Hua Hu ◽  
Zhi-Bin Huang ◽  
Da-Qing Shi
Keyword(s):  
Domino Reaction ◽  
Highly Efficient ◽  
Efficient Construction

scholarly journals A Four-Component Domino Reaction: An Eco-Compatible and Highly Efficient Construction of 1,8-Naphthyridine Derivatives, Their In Silico Molecular Docking, Drug Likeness, ADME, and Toxicity Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Ankita Garg ◽  
Aschalew Tadesse ◽  
Rajalakshmanan Eswaramoorthy
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Environmental Parameters ◽  
Direct Access ◽  
Domino Reaction ◽  
One Pot ◽  
Synthetic Strategy ◽  
Efficient Construction ◽  
High Yields ◽  
In Silico Molecular Docking

A multicomponent domino reaction of enaminone, malononitrile, and o-phthalaldehyde has been established, providing direct access to novel highly functionalized pentacyclic cyclopenta [b] indeno [1, 2, 3-de] [1,8] naphthyridine derivatives. The simplicity of execution, readily available substrates, high yields, excellent functional group tolerance, scalability, and good scores of environmental parameters make this synthetic strategy more sustainable and worthy of further attention. This one-pot transformation, which involved multiple steps and did not require the use of a catalyst, constructed four new C-C bonds, two new C-N bonds, and three new rings, with efficient use of all reactants. Furthermore, we performed in silico molecular docking analysis for prediction of anticancer (against human topoisomerase IIβ protein) and antimicrobial (against E.coli. DNA gyrase B protein) activities. Drug likeness and ADMET studies were also predicted. Overall investigation indicates that compound 6i may serve as a candidate that could be developed as potential anticancer and antimicrobial agent among all.

ChemInform Abstract: Highly Efficient Construction of Pentacyclic Benzo[b]indeno-[1,2,3-de][1,8]naphthyridine Derivatives via Four-Component Domino Reaction.

ChemInform ◽  
2013 ◽  
Vol 44 (47) ◽  
pp. no-no
Author(s):  
Cheng-Pao Cao ◽  
Wei Lin ◽  
Ming-Hua Hu ◽  
Zhi-Bin Huang ◽  
Da-Qing Shi
Keyword(s):  
Domino Reaction ◽  
Highly Efficient ◽  
Efficient Construction

Enzyme-catalyzed domino reaction: efficient construction of spirocyclic oxindole skeleton using porcine pepsin

2016 ◽  
Vol 6 (7) ◽  
pp. 2239-2248 ◽  
Author(s):  
Yan-Hong He ◽  
Tao He ◽  
Jun-Tao Guo ◽  
Rui Li ◽  
Yang Xiang ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Michael Reaction ◽  
Domino Reaction ◽  
Porcine Pepsin ◽  
Efficient Construction ◽  
Spirocyclic Oxindole

Pepsin from porcine gastric mucosa was used as a catalyst in the domino Knoevenagel/Michael/Michael reaction for the synthesis of spirooxindoles.

Efficient Construction of Tri- and Tetracyclic Heterocycles from Linear 1,6-Dienes by a Domino Reaction

2008 ◽  
Vol 14 (10) ◽  
pp. 3110-3117 ◽  
Author(s):  
Yimin Hu ◽  
Fengfa Song ◽  
Fenghua Wu ◽  
Dong Cheng ◽  
Shaowu Wang
Keyword(s):  
Domino Reaction ◽  
Efficient Construction

Highly efficient construction of a bridged pentacyclic skeleton via a six-component domino reaction under microwave irradiation

2015 ◽  
Vol 17 (3) ◽  
pp. 1535-1545 ◽  
Author(s):  
Lei Fu ◽  
Xian Feng ◽  
Juan-Juan Zhang ◽  
Jun-Die Hu ◽  
Zhan Xun ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Domino Reaction ◽  
Highly Efficient ◽  
Efficient Construction

A bridged pentacyclic skeleton has been constructed via a six-component domino reaction under microwave irradiation.

An Efficient Construction of 9-(Guaiazulen-1-yl)xanthen-4(9H)-ones via Domino Reaction

Heterocycles ◽  
2018 ◽  
Vol 96 (8) ◽  
pp. 1445
Author(s):  
Dao-Lin Wang ◽  
Jiao Xu ◽  
Yu Liu ◽  
Wei Ma ◽  
Xing-Wei Zhang
Keyword(s):  
Domino Reaction ◽  
Efficient Construction

Efficient Construction of Order-Preserving Encryption Using Pseudo Random Function

2015 ◽  
Vol E98.B (7) ◽  
pp. 1276-1283 ◽  
Author(s):  
Nam-Su JHO ◽  
Ku-Young CHANG ◽  
Do-Won HONG
Keyword(s):  
Random Function ◽  
Efficient Construction
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