Enzyme-catalyzed domino reaction: efficient construction of spirocyclic oxindole skeleton using porcine pepsin

2016 ◽  
Vol 6 (7) ◽  
pp. 2239-2248 ◽  
Author(s):  
Yan-Hong He ◽  
Tao He ◽  
Jun-Tao Guo ◽  
Rui Li ◽  
Yang Xiang ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Michael Reaction ◽  
Domino Reaction ◽  
Porcine Pepsin ◽  
Efficient Construction ◽  
Spirocyclic Oxindole

Pepsin from porcine gastric mucosa was used as a catalyst in the domino Knoevenagel/Michael/Michael reaction for the synthesis of spirooxindoles.

Ultrasound Promoted Efficient Construction of Polycyclic-Fused Pyrazolo[4,3-c]pyridines via Domino Reaction

Heterocycles ◽  
2017 ◽  
Vol 94 (10) ◽  
pp. 1958 ◽  
Author(s):  
Dao-Lin Wang ◽  
Jiao Xu ◽  
Ting Zhou ◽  
Liang Yan ◽  
Wei Ma
Keyword(s):  
Domino Reaction ◽  
Efficient Construction

A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles

2011 ◽  
Vol 47 (19) ◽  
pp. 5593 ◽  
Author(s):  
Liang-Liang Wang ◽  
Lin Peng ◽  
Jian-Fei Bai ◽  
Li-Na Jia ◽  
Xi-Ya Luo ◽  
...  
Keyword(s):  
Michael Reaction ◽  
Efficient Construction

Highly efficient construction of pentacyclic benzo[b]indeno-[1,2,3-de][1,8]naphthyridine derivatives via four-component domino reaction

2013 ◽  
Vol 49 (62) ◽  
pp. 6983 ◽  
Author(s):  
Cheng-Pao Cao ◽  
Wei Lin ◽  
Ming-Hua Hu ◽  
Zhi-Bin Huang ◽  
Da-Qing Shi
Keyword(s):  
Domino Reaction ◽  
Highly Efficient ◽  
Efficient Construction

scholarly journals A Four-Component Domino Reaction: An Eco-Compatible and Highly Efficient Construction of 1,8-Naphthyridine Derivatives, Their In Silico Molecular Docking, Drug Likeness, ADME, and Toxicity Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Ankita Garg ◽  
Aschalew Tadesse ◽  
Rajalakshmanan Eswaramoorthy
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Environmental Parameters ◽  
Direct Access ◽  
Domino Reaction ◽  
One Pot ◽  
Synthetic Strategy ◽  
Efficient Construction ◽  
High Yields ◽  
In Silico Molecular Docking

A multicomponent domino reaction of enaminone, malononitrile, and o-phthalaldehyde has been established, providing direct access to novel highly functionalized pentacyclic cyclopenta [b] indeno [1, 2, 3-de] [1,8] naphthyridine derivatives. The simplicity of execution, readily available substrates, high yields, excellent functional group tolerance, scalability, and good scores of environmental parameters make this synthetic strategy more sustainable and worthy of further attention. This one-pot transformation, which involved multiple steps and did not require the use of a catalyst, constructed four new C-C bonds, two new C-N bonds, and three new rings, with efficient use of all reactants. Furthermore, we performed in silico molecular docking analysis for prediction of anticancer (against human topoisomerase IIβ protein) and antimicrobial (against E.coli. DNA gyrase B protein) activities. Drug likeness and ADMET studies were also predicted. Overall investigation indicates that compound 6i may serve as a candidate that could be developed as potential anticancer and antimicrobial agent among all.

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