Facile Synthesis of 3-(Succinimid-3-yl)-2-oxo-2,3-dihydroimidazo[1,2-a]pyridine Derivatives by Sequential Intra- and Intermolecular Michael Reactions between 2-Aminopyridines and Maleimides

Heterocycles ◽  
2011 ◽  
Vol 83 (1) ◽  
pp. 47 ◽  
Author(s):  
Tetsuro Shimo ◽  
Tomoko Itoh ◽  
Yasutaka Araki ◽  
Tetsuo Iwanaga ◽  
Teruo Shinmyozu ◽  
...  
Keyword(s):  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
Michael Reactions

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

Synthetic Studies Using α,β-Unsaturated Nitriles: Facile Synthesis of Pyridine Derivatives

Synthesis ◽  
1981 ◽  
Vol 1981 (07) ◽  
pp. 531-533 ◽  
Author(s):  
Satoshi Kambe ◽  
Koji Saito ◽  
Akio Sakurai ◽  
Hiroshi Midorikawa
Keyword(s):  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
Synthetic Studies

Aza-Michael Reactions in Ionic Liquids. A Facile Synthesis of β-Amino Compounds

2003 ◽  
Vol 32 (11) ◽  
pp. 988-989 ◽  
Author(s):  
J. S. Yadav ◽  
B. V. S. Reddy ◽  
A. K. Basak ◽  
A. V. Narsaiah
Keyword(s):  
Ionic Liquids ◽  
Facile Synthesis ◽  
Michael Reactions ◽  
Amino Compounds

ChemInform Abstract: A New Strategy for Facile Synthesis of Tetrasubstituted Pyridine Derivatives.

ChemInform ◽  
2013 ◽  
Vol 45 (2) ◽  
pp. no-no
Author(s):  
Jun Chen ◽  
Hangcheng Ni ◽  
Wenteng Chen ◽  
Guolin Zhang ◽  
Yongping Yu
Keyword(s):  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
New Strategy
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