The Nicotinic Acid-p-Aminophenylalanine-Hydroxybenzoic Acid Triads Induce Apoptosis in Human Leukemia U937 Cells

Heterocycles ◽  
2007 ◽  
Vol 71 (7) ◽  
pp. 1503 ◽  
Author(s):  
Akira Katoh ◽  
Mika Yamaguchi ◽  
Ryota Saito ◽  
Keiichiro Utsumi ◽  
Akira Ochiai ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
Hydroxybenzoic Acid ◽  
Human Leukemia ◽  
U937 Cells

Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells

2009 ◽  
Vol 23 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Cheng-Yun Jin ◽  
Cheol Park ◽  
Jun-Hyuk Lee ◽  
Kyung Tae Chung ◽  
Taeg Kyu Kwon ◽  
...  
Keyword(s):  
Small Molecule ◽  
Human Leukemia ◽  
U937 Cells ◽  
Induced Apoptosis

scholarly journals Naja atra Cardiotoxin 3 Elicits Autophagy and Apoptosis in U937 Human Leukemia Cells through the Ca2+/PP2A/AMPK Axis

Toxins ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 527 ◽  
Author(s):  
Jing-Ting Chiou ◽  
Yi-Jun Shi ◽  
Liang-Jun Wang ◽  
Chia-Hui Huang ◽  
Yuan-Chin Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Membrane Damage ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
U937 Cells ◽  
Cell Membrane Damage ◽  
Human Leukemia Cells ◽  
Phosphatase 2A ◽  
Induced Apoptosis ◽  
Naja Atra

Cardiotoxins (CTXs) are suggested to exert their cytotoxicity through cell membrane damage. Other studies show that penetration of CTXs into cells elicits mitochondrial fragmentation or lysosome disruption, leading to cell death. Considering the role of AMPK-activated protein kinase (AMPK) in mitochondrial biogenesis and lysosomal biogenesis, we aimed to investigate whether the AMPK-mediated pathway modulated Naja atra (Taiwan cobra) CTX3 cytotoxicity in U937 human leukemia cells. Our results showed that CTX3 induced autophagy and apoptosis in U937 cells, whereas autophagic inhibitors suppressed CTX3-induced apoptosis. CTX3 treatment elicited Ca2+-dependent degradation of the protein phosphatase 2A (PP2A) catalytic subunit (PP2Acα) and phosphorylation of AMPKα. Overexpression of PP2Acα mitigated the CTX3-induced AMPKα phosphorylation. CTX3-induced autophagy was via AMPK-mediated suppression of the Akt/mTOR pathway. Removal of Ca2+ or suppression of AMPKα phosphorylation inhibited the CTX3-induced cell death. CTX3 was unable to induce autophagy and apoptosis in U937 cells expressing constitutively active Akt. Met-modified CTX3 retained its membrane-perturbing activity, however, it did not induce AMPK activation and death of U937 cells. These results conclusively indicate that CTX3 induces autophagy and apoptosis in U937 cells via the Ca2+/PP2A/AMPK axis, and suggest that the membrane-perturbing activity of CTX3 is not crucial for the cell death signaling pathway induction.

scholarly journals Octylcaffeate Induced Apoptosis in Human Leukemia U937 Cells

2005 ◽  
Vol 28 (12) ◽  
pp. 2338-2341 ◽  
Author(s):  
Mayuko Ujibe ◽  
Syu-ichi Kanno ◽  
Yu Osanai ◽  
Kimiko Koiwai ◽  
Takaharu Ohtake ◽  
...  
Keyword(s):  
Human Leukemia ◽  
U937 Cells ◽  
Induced Apoptosis
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