Molecular Design and Synthesis of 4,8-Di(hetero)arylquinazolines with Potential Applications in Quadratic Nonlinear Optics. Diazines Part 48

Heterocycles ◽  
2007 ◽  
Vol 71 (8) ◽  
pp. 1723 ◽  
Author(s):  
Nelly Plé ◽  
Alexandrine Busch ◽  
Alain Turck ◽  
Kamila Nowicka ◽  
Alberto Barsella ◽  
...  
Keyword(s):  
Nonlinear Optics ◽  
Molecular Design ◽  
Design And Synthesis ◽  
Potential Applications

Design and synthesis of new antifungals based on N- un-substituted azoles as 14α demethylase inhibitor

2020 ◽  
Vol 16 ◽  
Author(s):  
Asghar Davood ◽  
Aneseh Rahimi ◽  
Maryam Iman ◽  
Parisa Azerang ◽  
Soroush Sardari ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Antifungal Agents ◽  
Molecular Design ◽  
Pathogenic Fungi ◽  
Antimicrobial Activities ◽  
Docking Studies ◽  
Receptor Interaction ◽  
Main Role ◽  
Design And Synthesis ◽  
Antifungal Antibiotics

Objective(s): Azole antifungal agents, which are widely used as antifungal antibiotics, inhibit cytochrome P450 sterol 14α-demethylase (CYP51). Nearly all azole antifungal agents are N-substituted azoles. In addition, an azolylphenalkyl pharmacophore is uniquely shared by all azole antifungals. Due to importance of nitrogen atom of azoles (N-3 of imidazole and N-4 of triazole) in coordination with heme in the binding site of the enzyme, here a group of N- un-substituted azoles in which both of nitrogen is un-substituted was reported. Materials and Methods: Designed compounds were synthesized by reaction of imidazole-4-carboxaldehyde with appropriate arylamines and subsequently reduced to desired amine derivatives. Antifungal activity against Candida albicans and Saccharomyces cervisiae were done using a broth micro-dilution assay. Docking studies were done using AutoDock. Results: Antimicrobial evaluation revealed that some of these compounds exhibited moderate antimicrobial activities against tested pathogenic fungi, wherein compound 3, 7 and 8 were potent. Docking studies propose that all of the prepared azoles interacted with 14α-DM, wherein azole-heme coordination play main role in drug-receptor interaction. Conclusion: Our results offer some useful references in order to molecular design performance or modification of this series of compounds as a lead compound to discover new and potent antimicrobial agents.

Short Review and opinion: New matter properties and applications based on Hybrids Graphene based Metamaterials

2020 ◽  
Vol 04 ◽  
Author(s):  
A. Guillermo Bracamonte
Keyword(s):  
Short Review ◽  
New Materials ◽  
Design And Synthesis ◽  
Chemical Structures ◽  
Current State ◽  
Potential Applications ◽  
Fundamental Research ◽  
Miniaturized Instrumentation ◽  
And Control ◽  
Conductive Properties

: Graphene as Organic material showed special attention due to their electronic and conductive properties. Moreover, its highly conjugated chemical structures and relative easy modification permitted varied design and control of targeted properties and applications. In addition, this Nanomaterial accompanied with pseudo Electromagnetic fields permitted photonics, electronics and Quantum interactions with their surrounding that generated new materials properties. In this context, this short Review, intends to discuss many of these studies related with new materials based on graphene for light and electronic interactions, conductions, and new modes of non-classical light generation. It should be highlighted that these new materials and metamaterials are currently in progress. For this reason it was showed and discussed some representative examples from Fundamental Research with Potential Applications as well as for their incorporations to real Advanced devices and miniaturized instrumentation. In this way, it was proposed this Special issue entitled “Design and synthesis of Hybrids Graphene based Metamaterials”, in order to open and share the knowledge of the Current State of the Art in this Multidisciplinary field.

Molecular design and synthesis of new heterobivalent compounds based on chlorambucil and colchicine

2020 ◽  
Vol 30 (6) ◽  
pp. 706-708
Author(s):  
Evgenia V. Nurieva ◽  
Nikolay A. Zefirov ◽  
Nele Fritsch ◽  
Elena R. Milaeva ◽  
Sergei A. Kuznetsov ◽  
...  
Keyword(s):  
Molecular Design ◽  
Design And Synthesis

scholarly journals Perylene Imide-Based Optical Chemosensors for Vapor Detection

Chemosensors ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Miao Zhang ◽  
Jiangfan Shi ◽  
Chenglong Liao ◽  
Qingyun Tian ◽  
Chuanyi Wang ◽  
...  
Keyword(s):  
Molecular Design ◽  
Phase Detection ◽  
Time Reversibility ◽  
Strong Electron ◽  
Vapor Detection ◽  
Multiple Sensors ◽  
Optical Chemosensors ◽  
Potential Applications ◽  
High Fluorescence ◽  
Organic Amines

Perylene imide (PI) molecules and materials have been extensively studied for optical chemical sensors, particularly those based on fluorescence and colorimetric mode, taking advantage of the unique features of PIs such as structure tunability, good thermal, optical and chemical stability, strong electron affinity, strong visible light absorption and high fluorescence quantum yield. PI-based optical chemosensors have now found broad applications in gas phase detection of chemicals, including explosives, biomarkers of some food and diseases (such as organic amines (alkylamines and aromatic amines)), benzene homologs, organic peroxides, phenols and nitroaromatics, etc. In this review, the recent research on PI-based fluorometric and colorimetric sensors, as well as array technology incorporating multiple sensors, is reviewed along with the discussion of potential applications in environment, health and public safety areas. Specifically, we discuss the molecular design and aggregate architecture of PIs in correlation with the corresponding sensor performances (including sensitivity, selectivity, response time, recovery time, reversibility, etc.). We also provide a perspective summary highlighting the great potential for future development of PIs optical chemosensors, especially in the sensor array format that will largely enhance the detection specificity in complexed environments.

Molecular design and synthesis of fluorescence PET (photo-induced electron transfer) sensors for detection of water in organic solvents

RSC Advances ◽  
2013 ◽  
Vol 3 (45) ◽  
pp. 23255 ◽  
Author(s):  
Yousuke Ooyama ◽  
Koji Uenaka ◽  
Ai Matsugasako ◽  
Yutaka Harima ◽  
Joji Ohshita
Keyword(s):  
Electron Transfer ◽  
Organic Solvents ◽  
Molecular Design ◽  
Design And Synthesis ◽  
Photo Induced Electron Transfer

Molecular design and synthesis of 1,4-disubstituted piperazines as α1-adrenergic receptor blockers

2014 ◽  
Vol 54 ◽  
pp. 21-30 ◽  
Author(s):  
Dalal A. Abou El-Ella ◽  
Mohammed M. Hussein ◽  
Rabah A.T. Serya ◽  
Rana M. Abdel Naby ◽  
Ahmed M. Al-Abd ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Molecular Design ◽  
Design And Synthesis ◽  
Receptor Blockers
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