Molecular design and synthesis of fluorescence PET (photo-induced electron transfer) sensors for detection of water in organic solvents

RSC Advances ◽  
2013 ◽  
Vol 3 (45) ◽  
pp. 23255 ◽  
Author(s):  
Yousuke Ooyama ◽  
Koji Uenaka ◽  
Ai Matsugasako ◽  
Yutaka Harima ◽  
Joji Ohshita
Keyword(s):  
Electron Transfer ◽  
Organic Solvents ◽  
Molecular Design ◽  
Design And Synthesis ◽  
Photo Induced Electron Transfer

Effects of Organic Solvents on Charge Separation in Photo-induced Electron Transfer from Xanthene Dyes to Methyl Viologen

1989 ◽  
Vol 18 (9) ◽  
pp. 1555-1558 ◽  
Author(s):  
Yoshinobu Nishimura ◽  
Hiroaki Misawa ◽  
Hirochika Sakuragi ◽  
Katsumi Tokumaru
Keyword(s):  
Electron Transfer ◽  
Organic Solvents ◽  
Charge Separation ◽  
Methyl Viologen ◽  
Xanthene Dyes ◽  
Photo Induced Electron Transfer

Detection of water in organic solvents by photo-induced electron transfer method

2011 ◽  
Vol 9 (5) ◽  
pp. 1314-1316 ◽  
Author(s):  
Yousuke Ooyama ◽  
Minako Sumomogi ◽  
Tomoya Nagano ◽  
Kohei Kushimoto ◽  
Kenji Komaguchi ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Organic Solvents ◽  
Photo Induced Electron Transfer ◽  
Transfer Method

Design and synthesis of new antifungals based on N- un-substituted azoles as 14α demethylase inhibitor

2020 ◽  
Vol 16 ◽  
Author(s):  
Asghar Davood ◽  
Aneseh Rahimi ◽  
Maryam Iman ◽  
Parisa Azerang ◽  
Soroush Sardari ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Antifungal Agents ◽  
Molecular Design ◽  
Pathogenic Fungi ◽  
Antimicrobial Activities ◽  
Docking Studies ◽  
Receptor Interaction ◽  
Main Role ◽  
Design And Synthesis ◽  
Antifungal Antibiotics

Objective(s): Azole antifungal agents, which are widely used as antifungal antibiotics, inhibit cytochrome P450 sterol 14α-demethylase (CYP51). Nearly all azole antifungal agents are N-substituted azoles. In addition, an azolylphenalkyl pharmacophore is uniquely shared by all azole antifungals. Due to importance of nitrogen atom of azoles (N-3 of imidazole and N-4 of triazole) in coordination with heme in the binding site of the enzyme, here a group of N- un-substituted azoles in which both of nitrogen is un-substituted was reported. Materials and Methods: Designed compounds were synthesized by reaction of imidazole-4-carboxaldehyde with appropriate arylamines and subsequently reduced to desired amine derivatives. Antifungal activity against Candida albicans and Saccharomyces cervisiae were done using a broth micro-dilution assay. Docking studies were done using AutoDock. Results: Antimicrobial evaluation revealed that some of these compounds exhibited moderate antimicrobial activities against tested pathogenic fungi, wherein compound 3, 7 and 8 were potent. Docking studies propose that all of the prepared azoles interacted with 14α-DM, wherein azole-heme coordination play main role in drug-receptor interaction. Conclusion: Our results offer some useful references in order to molecular design performance or modification of this series of compounds as a lead compound to discover new and potent antimicrobial agents.

Molecular design and synthesis of new heterobivalent compounds based on chlorambucil and colchicine

2020 ◽  
Vol 30 (6) ◽  
pp. 706-708
Author(s):  
Evgenia V. Nurieva ◽  
Nikolay A. Zefirov ◽  
Nele Fritsch ◽  
Elena R. Milaeva ◽  
Sergei A. Kuznetsov ◽  
...  
Keyword(s):  
Molecular Design ◽  
Design And Synthesis

Molecular design and synthesis of 1,4-disubstituted piperazines as α1-adrenergic receptor blockers

2014 ◽  
Vol 54 ◽  
pp. 21-30 ◽  
Author(s):  
Dalal A. Abou El-Ella ◽  
Mohammed M. Hussein ◽  
Rabah A.T. Serya ◽  
Rana M. Abdel Naby ◽  
Ahmed M. Al-Abd ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Molecular Design ◽  
Design And Synthesis ◽  
Receptor Blockers
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