Flavone C-Glycosides from Isatis tinctoria Leaves

Heterocycles ◽  
2005 ◽  
Vol 65 (7) ◽  
pp. 1655 ◽  
Author(s):  
Matthias Hamburger ◽  
Yongxian Cheng ◽  
Bernd Schneider ◽  
Heidemarie Graf ◽  
Sven Adler ◽  
...  
Keyword(s):  
Isatis Tinctoria

scholarly journals Microscopic Mass Spectrometry Imaging Reveals the Distribution of Phytochemicals in the Dried Root of Isatis tinctoria

2021 ◽  
Vol 12 ◽  
Author(s):  
Li-Xing Nie ◽  
Jing Dong ◽  
Lie-Yan Huang ◽  
Xiu-Yu Qian ◽  
Chao-Jie Lian ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Viral Infections ◽  
Ion Trap ◽  
Partial Least Square ◽  
Least Square ◽  
Isatis Tinctoria ◽  
Chinese Medicines ◽  
Flight Mass Spectrometry ◽  
First Time

The dried root of Isatis tinctoria L. (Brassicaceae) is one of the most popular traditional Chinese medicines with well-recognized prevention and treatment effects against viral infections. Above 300 components have been isolated from this herb, but their spatial distribution in the root tissue remains unknown. In recent years, mass spectrometry imaging (MSI) has become a booming technology for capturing the spatial accumulation and localization of molecules in fresh plants, animal, or human tissues. However, few studies were conducted on the dried herbal materials due to the obstacles in cryosectioning. In this study, distribution of phytochemicals in the dried root of Isatis tinctoria was revealed by microscopic mass spectrometry imaging, with application of atmospheric pressure–matrix-assisted laser desorption/ionization (AP-MALDI) and ion trap–time-of-flight mass spectrometry (IT-TOF/MS). After optimization of the slice preparation and matrix application, 118 ions were identified without extraction and isolation, and the locations of some metabolites in the dried root of Isatis tinctoria were comprehensively visualized for the first time. Combining with partial least square (PLS) regression, samples collected from four habitats were differentiated unambiguously based on their mass spectrometry imaging.

scholarly journals Metabolic markers for the yield of lipophilic indole alkaloids in dried woad leaves (Isatis tinctoria L.)

2019 ◽  
Vol 163 ◽  
pp. 89-98 ◽  
Author(s):  
Thi-Kieu-Oanh Nguyen ◽  
Paulo Marcelo ◽  
Eric Gontier ◽  
Rebecca Dauwe
Keyword(s):  
Indole Alkaloids ◽  
Metabolic Markers ◽  
Isatis Tinctoria

The Production of Indigo in the Human Organism

1911 ◽  
Vol 57 (237) ◽  
pp. 291-311 ◽  
Author(s):  
R. V. Stanford
Keyword(s):  
Striking Feature ◽  
Human Organism ◽  
Isatis Tinctoria ◽  
Half Century ◽  
The Past ◽  
Past Half Century ◽  
Animal Metabolism ◽  
Product Forms ◽  
Past Half ◽  
Vegetable Product

It has long been known that in certain circumstances the dye-stuff indigo, or substances very nearly related to it, may appear as products of animal metabolism, and this fact has not failed to attract attention from physiologists, chemists and medical men. Indigo, in fact, possesses a “fatal gift of beauty,” which has always made it a focus of interest. Of no substance is the history easier to trace. In the earliest times it was obtained from the plant Isatis tinctoria, and served as dye and pigment under the name of woad, being no doubt a striking feature at meetings of the wild Silures in this locality some 2,000 years ago. More recently, during the past half century, the problem of the production of synthetic indigo has absorbed enormous sums of money and the energies of an army of chemists, and the successful competition which it now wages with the vegetable product forms one of the best instances of the return eventually obtained by those who cast their bread upon the waters, financing research in the hope of a return which they cannot definitely foresee.

scholarly journals Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

Plants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 298 ◽  
Author(s):  
Jasmine Speranza ◽  
Natalizia Miceli ◽  
Maria Fernanda Taviano ◽  
Salvatore Ragusa ◽  
Inga Kwiecień ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Biological Properties ◽  
Biologically Active ◽  
Raw Material ◽  
Future Research ◽  
Shoot Cultures ◽  
Isatis Tinctoria ◽  
Enhanced Production

Isatis tinctoria L. (Brassicaceae), which is commonly known as woad, is a species with an ancient and well-documented history as an indigo dye and medicinal plant. Currently, I. tinctoria is utilized more often as medicinal remedy and also as a cosmetic ingredient. In 2011, I. tinctoria root was accepted in the official European phytotherapy by introducing its monograph in the European Pharmacopoeia. The biological properties of raw material have been known from Traditional Chinese Medicine (TCM). Over recent decades, I. tinctoria has been investigated both from a phytochemical and a biological point of view. The modern in vitro and in vivo scientific studies proved anti-inflammatory, anti-tumour, antimicrobial, antiviral, analgesic, and antioxidant activities. The phytochemical composition of I. tinctoria has been thoroughly investigated and the plant was proven to contain many valuable biologically active compounds, including several alkaloids, among which tryptanthrin, indirubin, indolinone, phenolic compounds, and polysaccharides as well as glucosinolates, carotenoids, volatile constituents, and fatty acids. This article provides a general botanical and ethnobotanical overview that summarizes the up-to-date knowledge on the phytochemistry and biological properties of this valuable plant in order to support its therapeutic potential. Moreover, the biotechnological studies on I. tinctoria, which mainly focused on hairy root cultures for the enhanced production of flavonoids and alkaloids as well as on the establishment of shoot cultures and micropropagation protocols, were reviewed. They provide input for future research prospects.

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