scholarly journals Metabolic markers for the yield of lipophilic indole alkaloids in dried woad leaves (Isatis tinctoria L.)

2019 ◽  
Vol 163 ◽  
pp. 89-98 ◽  
Author(s):  
Thi-Kieu-Oanh Nguyen ◽  
Paulo Marcelo ◽  
Eric Gontier ◽  
Rebecca Dauwe
Keyword(s):  
Indole Alkaloids ◽  
Metabolic Markers ◽  
Isatis Tinctoria

Four new indole alkaloids from the roots of Isatis tinctoria

2020 ◽  
pp. 1-7 ◽  
Author(s):  
Dongdong Zhang ◽  
Yu Sun ◽  
Yanhong Shi ◽  
Ximin Wu ◽  
Qi Jia ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Isatis Tinctoria

scholarly journals A Comprehensive Review of the Chemistry, Pharmacokinetics, Pharmacology, Clinical Applications, Adverse Events, and Quality Control of Indigo Naturalis

2021 ◽  
Vol 12 ◽  
Author(s):  
Quan Sun ◽  
Jing Leng ◽  
Ling Tang ◽  
Lijuan Wang ◽  
Chaomei Fu
Keyword(s):  
Quality Control ◽  
Adverse Events ◽  
Indole Alkaloids ◽  
Clinical Applications ◽  
Inhibitory Effects ◽  
Curative Effect ◽  
Isatis Tinctoria ◽  
Comprehensive Information ◽  
Pharmacological Studies ◽  
Indigo Naturalis

Indigo naturalis (IN), which is derived from indigo plants such as Strobilanthes cusia (Nees) Kuntze, Persicaria tinctoria (Aiton) Spach, and Isatis tinctoria L., has been traditionally used in the treatment of hemoptysis, epistaxis, chest pain, aphtha, and infantile convulsion in China for thousands of years. Clinical trials have shown that the curative effect of IN for psoriasis and ulcerative colitis (UC) is remarkable. A total of sixty-three compounds, including indole alkaloids, terpenoids, organic acids, steroids, and nucleosides, have been isolated from IN, of which indole alkaloids are the most important. Indirubin, isolated from IN, was used as a new agent to treat leukemia in China in the 1970s. Indirubin is also an active ingredient in the treatment of psoriasis. Pharmacological studies have confirmed that IN has inhibitory effects on inflammation, tumors, bacteria, and psoriasis. Indigo, indirubin, tryptanthrin, isorhamnetin, indigodole A, and indigodole C are responsible for these activities. This review provides up-to-date and comprehensive information on IN with regard to its chemistry, pharmacokinetics, pharmacology, clinical applications, adverse events, and quality control. This review may also serve a reference for further research on IN.

Four undescribed sulfur-containing indole alkaloids with nitric oxide inhibitory activities from Isatis tinctoria L. roots

2020 ◽  
Vol 174 ◽  
pp. 112337 ◽  
Author(s):  
Dongdong Zhang ◽  
Deqing Ruan ◽  
Jingyi Li ◽  
Zhaoqiang Chen ◽  
Weiliang Zhu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Indole Alkaloids ◽  
Isatis Tinctoria ◽  
Inhibitory Activities ◽  
Sulfur Containing

Indole alkaloids from Duroia macrophylla (Rubiaceae)

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
CV Nunez ◽  
V Roumy ◽  
DWO Mesquita ◽  
ASS Mesquita ◽  
S Sahpaz ◽  
...  
Keyword(s):  
Indole Alkaloids

Indole alkaloids from plants: Novel structures, bioactivities and preclinical investigations

Planta Medica ◽  
2015 ◽  
Vol 81 (05) ◽  
Author(s):  
XH Cai ◽  
T Feng ◽  
XN Li ◽  
YP Liu ◽  
JH Shang ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Novel Structures

A novel class of indole alkaloids isolated from Flindersia pimenteliana (Rutaceae)

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
LP Robertson ◽  
S Duffy ◽  
VM Avery ◽  
AR Carroll
Keyword(s):  
Indole Alkaloids

Gene expression analysis of metabolic markers during bone regeneration in a rat model

2014 ◽  
Vol 23 (03) ◽  
pp. 207-211
Author(s):  
C. Kasch ◽  
A. Osterberg ◽  
Thordis Granitzka ◽  
T. Lindner ◽  
M. Haenle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Analysis ◽  
Saline Solution ◽  
Female Rats ◽  
Synthesis Rate ◽  
Metabolic Markers ◽  
Expression Levels ◽  
Fibrotic Tissue ◽  
Intermittent Pth ◽  
Lower Expression

SummaryThe RANK/RANKL/OPG system plays an important role in the regulation of bone metabolism and bony integration around implants. The aim of this study was to analyse gene expression of OPG, RANK, and RANKL in regenerating bone during implant integration. Additionally, the effect of intermittent para - thyroid hormone (PTH) treatment was analysed. A titanium chamber was implanted in the proximal tibiae of 48 female rats. The animals received either human PTH or saline solution (NaCl). After 21 and 42 days, RNA was isolated from tissue adjacent to the implant and expression of RANK, RANKL, and OPG was analysed. After 21 days, very low expression levels of all genes were shown. In contrast, increased gene expression after 42 days was determined. Expression of RANK and RANKL was lower than that for OPG. The lower expression levels after 21 days might be due to still ossifying, fibrotic tissue around the titanium chamber. An increased OPG synthesis rate associated with decreased RANKL expression after 42 days revealed bone-forming processes. Despite significant differences in gene expression between the time points, only slight differences were observed between application of intermittent PTH and NaCl after a period of 42 days.

Ziprasidone's Effect on Metabolic Markers in Patients with Diabetes and Chronic Schizophrenia

2012 ◽  
Vol 5 (4) ◽  
pp. 185-192 ◽  
Author(s):  
J. Lindenmayer ◽  
Frank Tedeschi ◽  
Anna Yusim ◽  
Anzalee Khan ◽  
Saurabh Kaushik ◽  
...  
Keyword(s):  
Chronic Schizophrenia ◽  
Metabolic Markers ◽  
Patients With Diabetes
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