Monoepoxidation of Humulene 2,3-Epoxide to Humulene 2,3;6,7-Diepoxides. Observation of the Rotation of the Double Bond Plane by 1H NMR Spectral Analysis and Conformation

Heterocycles ◽  
2003 ◽  
Vol 59 (1) ◽  
pp. 387
Author(s):  
Kiyoharu Hayano ◽  
Katsura Mochizuki
Keyword(s):  
Spectral Analysis ◽  
Double Bond ◽  
1H Nmr ◽  
Bond Plane

Facile Synthetic Protocols for the preparation of New Impurities in Pemetrexed Disodium Heptahydrate as an Anti-Cancer Drug

2021 ◽  
Vol 18 ◽  
Author(s):  
Rama Mohana Reddy Jaggavarapu ◽  
Venkatanarayana Muvvala ◽  
Ghojala Venkatareddy ◽  
Ravi Kumar Cheedarala
Keyword(s):  
Quality Control ◽  
Spectral Analysis ◽  
1H Nmr ◽  
Structure Elucidation ◽  
Research Work ◽  
Synthetic Methods ◽  
Cancer Drug ◽  
The Novel ◽  
Anti Cancer ◽  
Pemetrexed Disodium

: A facile synthetic protocols were employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis such as 1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for the quality control.

Synthesis and Study of Dynamic 1H NMR of Carbon–Carbon Double Bond Rotation Energy Barrier in Stable Phenothiazine Phosphorus Ylides

2007 ◽  
Vol 182 (3) ◽  
pp. 647-655 ◽  
Author(s):  
Malek Taher Maghsoodlou ◽  
Sayyed Mostafa Habibi Khorassani ◽  
Uranous Niroumand ◽  
Faramarz Rostami Charati ◽  
Maryam Khosrosharodi
Keyword(s):  
Double Bond ◽  
1H Nmr ◽  
Energy Barrier ◽  
Phosphorus Ylides ◽  
Bond Rotation ◽  
Carbon Double Bond ◽  
Dynamic 1H Nmr ◽  
Rotation Energy

1H NMR spectral analysis and conformational behavior of n-alkanes in different chemical environments

2012 ◽  
Vol 50 (9) ◽  
pp. 598-607 ◽  
Author(s):  
Tuulia Tynkkynen ◽  
Tommi Hassinen ◽  
Mika Tiainen ◽  
Pasi Soininen ◽  
Reino Laatikainen
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
Conformational Behavior

scholarly journals Complete 1H-NMR and 13C-NMR spectral analysis of the pairs of 20(S) and 20(R) ginsenosides

2014 ◽  
Vol 38 (3) ◽  
pp. 194-202 ◽  
Author(s):  
Heejung Yang ◽  
Jeom Yong Kim ◽  
Sun Ok Kim ◽  
Young Hyo Yoo ◽  
Sang Hyun Sung
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr

scholarly journals 2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide

Molbank ◽  
10.3390/m1164 ◽  
2020 ◽  
Vol 2020 (4) ◽  
pp. M1164
Author(s):  
Mariia Nesterkina ◽  
Dmytro Barbalat ◽  
Ildar Rakipov ◽  
Iryna Kravchenko
Keyword(s):  
Mass Spectrometry ◽  
Valproic Acid ◽  
Spectral Analysis ◽  
Thermal Properties ◽  
1H Nmr ◽  
13C Nmr ◽  
Agent Based ◽  
Anticonvulsant Agent ◽  
Fab Mass Spectrometry

2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide was obtained in 80% yield via the Einhorn variation of the Schotten–Baumann method by (+)-camphor hydrazide condensation with valproic acid (VPA) chloride. The structure of the titled compound was verified by Raman, FTIR, 1H-NMR, and 13C-NMR spectral analysis along with FAB-mass spectrometry. Thermal properties of synthesized derivative were elucidated by DSC and its purity by HPLC. The compound was successfully tested as a potential anticonvulsant agent based on models of chemically- and electrically-induced seizures.

1,2,4-triazoles Clubbed Pyrimidine Compounds with Synthesis, Antimicrobial, Antituberculosis, Antimalarial, and Anti-protozoal Studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Navin B. Patel ◽  
Hetal I. Soni ◽  
Rahul B. Parmar ◽  
Manuel J. Chan-Bacab ◽  
Gildardo Rivera
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
Antifungal Agent ◽  
New Products ◽  
Antifungal Drugs ◽  
Bioactive Molecules ◽  
Mass Spectral Analysis ◽  
Mass Spectral

: Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best examples of antifungal drugs available in the market, which consist an active triazole moiety. Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial, an-tituberculosis, antimalarial, and anti-protozoal. N-[4-(substituted phenyl)-6-(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3A-J) were synthesized by different method as cyclization, condensation, purification and crystallization. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and anti-protozoal activities. These com-pounds satisfied the bioactive response and simple way for the synthesis.

Synthesis and Characterization of α,β-Unsaturated Hydroximoyl Chlorides and Hydroximates

2006 ◽  
Vol 59 (7) ◽  
pp. 439 ◽  
Author(s):  
James E. Johnson ◽  
Ling Lu ◽  
Houquan Dai ◽  
Diana C. Canseco ◽  
Krista M. Small ◽  
...  
Keyword(s):  
Double Bond ◽  
Chemical Shift ◽  
1H Nmr ◽  
Ultraviolet Irradiation ◽  
Sodium Methoxide ◽  
Synthesis And Characterization ◽  
Substitution Product ◽  
Nitrogen Double Bond ◽  
1H Nmr Chemical Shift

New α,β-unsaturated hydroximoyl chlorides (PhC(Cl)=CHC(Cl)=NOCH3) and hydroximates (PhC(OCH3)=CHC(OCH3)=NOCH3) were prepared. The ZZ-isomer of PhC(Cl)=CHC(Cl)=NOCH3 was prepared in four steps from ethyl benzoylacetate. Ultraviolet irradiation of the ZZ-isomer gives a mixture of all four possible isomers. Sodium methoxide was reacted with these isomers to determine the configuration about the carbon–carbon double bond for each. The Z-isomers reacted with sodium methoxide to give the corresponding alkyne by elimination whereas the E-isomers gave the substitution product. The configuration about the carbon–nitrogen double bond was determined from the 1H NMR chemical shift of the NOCH3 group.

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