1H NMR spectral analysis in series of heteroleptic triple-decker lanthanide phthalocyaninato complexes: Contact and dipolar contributions of lanthanide-induced shifts

Polyhedron ◽  
2010 ◽  
Vol 29 (1) ◽  
pp. 391-399 ◽  
Author(s):  
Alexander G. Martynov ◽  
Yulia G. Gorbunova
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
Lanthanide Induced Shifts ◽  
In Series

Facile Synthetic Protocols for the preparation of New Impurities in Pemetrexed Disodium Heptahydrate as an Anti-Cancer Drug

2021 ◽  
Vol 18 ◽  
Author(s):  
Rama Mohana Reddy Jaggavarapu ◽  
Venkatanarayana Muvvala ◽  
Ghojala Venkatareddy ◽  
Ravi Kumar Cheedarala
Keyword(s):  
Quality Control ◽  
Spectral Analysis ◽  
1H Nmr ◽  
Structure Elucidation ◽  
Research Work ◽  
Synthetic Methods ◽  
Cancer Drug ◽  
The Novel ◽  
Anti Cancer ◽  
Pemetrexed Disodium

: A facile synthetic protocols were employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis such as 1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for the quality control.

1H NMR spectral analysis and conformational behavior of n-alkanes in different chemical environments

2012 ◽  
Vol 50 (9) ◽  
pp. 598-607 ◽  
Author(s):  
Tuulia Tynkkynen ◽  
Tommi Hassinen ◽  
Mika Tiainen ◽  
Pasi Soininen ◽  
Reino Laatikainen
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
Conformational Behavior

scholarly journals Complete 1H-NMR and 13C-NMR spectral analysis of the pairs of 20(S) and 20(R) ginsenosides

2014 ◽  
Vol 38 (3) ◽  
pp. 194-202 ◽  
Author(s):  
Heejung Yang ◽  
Jeom Yong Kim ◽  
Sun Ok Kim ◽  
Young Hyo Yoo ◽  
Sang Hyun Sung
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr

scholarly journals 2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide

Molbank ◽  
10.3390/m1164 ◽  
2020 ◽  
Vol 2020 (4) ◽  
pp. M1164
Author(s):  
Mariia Nesterkina ◽  
Dmytro Barbalat ◽  
Ildar Rakipov ◽  
Iryna Kravchenko
Keyword(s):  
Mass Spectrometry ◽  
Valproic Acid ◽  
Spectral Analysis ◽  
Thermal Properties ◽  
1H Nmr ◽  
13C Nmr ◽  
Agent Based ◽  
Anticonvulsant Agent ◽  
Fab Mass Spectrometry

2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide was obtained in 80% yield via the Einhorn variation of the Schotten–Baumann method by (+)-camphor hydrazide condensation with valproic acid (VPA) chloride. The structure of the titled compound was verified by Raman, FTIR, 1H-NMR, and 13C-NMR spectral analysis along with FAB-mass spectrometry. Thermal properties of synthesized derivative were elucidated by DSC and its purity by HPLC. The compound was successfully tested as a potential anticonvulsant agent based on models of chemically- and electrically-induced seizures.

1,2,4-triazoles Clubbed Pyrimidine Compounds with Synthesis, Antimicrobial, Antituberculosis, Antimalarial, and Anti-protozoal Studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Navin B. Patel ◽  
Hetal I. Soni ◽  
Rahul B. Parmar ◽  
Manuel J. Chan-Bacab ◽  
Gildardo Rivera
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
Antifungal Agent ◽  
New Products ◽  
Antifungal Drugs ◽  
Bioactive Molecules ◽  
Mass Spectral Analysis ◽  
Mass Spectral

: Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best examples of antifungal drugs available in the market, which consist an active triazole moiety. Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial, an-tituberculosis, antimalarial, and anti-protozoal. N-[4-(substituted phenyl)-6-(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3A-J) were synthesized by different method as cyclization, condensation, purification and crystallization. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and anti-protozoal activities. These com-pounds satisfied the bioactive response and simple way for the synthesis.

1H NMR Spectral Simplification with Achiral and Chiral Lanthanide Shift Reagents. Part III:* Vinclozolin

1986 ◽  
Vol 40 (6) ◽  
pp. 743-745 ◽  
Author(s):  
Alexander Hatzis ◽  
Robert Rothchild
Keyword(s):  
1H Nmr ◽  
Nmr Spectra ◽  
Optical Purity ◽  
Molar Ratio ◽  
Molar Ratios ◽  
Chiral Reagent ◽  
H Nmr ◽  
Lanthanide Induced Shifts ◽  
Lanthanide Shift Reagents ◽  
Shift Reagents

The 60 MHz 1H NMR spectra of racemic vinclozolin, 1, have been studied at 28° in CDCI3 solution with the achiral reagent tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)europium(III), 2, and the chiral reagents tris[3-(trifluoromethylhydroxymethylene)- d-camphorato] europium(III), 3, and tris[3-(heptafluoropropylhydroxymethylene)- d-camphorato]europium(III), 4. Reagent 3 produced only small lanthanide-induced shifts and no observable enantiomeric shift differences, ΔΔδ, with 3:1 molar ratios as high as 1.40. In contrast, chiral reagent 4 produced substantial ΔΔδ for the proton, Hβ, at C-2 of the ethenyl group syn to the oxazolidinedione ring and smaller ΔΔδ for the anti proton, Hβ, at the above carbon and for the CH3. With a 4:1 molar ratio of 0.581, ΔΔδ of 7.0 Hz was seen for Hβ. A 4:1 ratio of about 0.41 should be optimum for optical purity determinations; as little as 5% of the minor enantiomer should be detectable.

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