Novel Synthesis of Pyrrolo[2,1-a]isoquinoline Using the Reaction of Isoquinolinium Salts with Active Methylene Compounds

Heterocycles ◽  
2001 ◽  
Vol 55 (3) ◽  
pp. 435 ◽  
Author(s):  
Reiko Fujita ◽  
Noriyuki Watanabe ◽  
Hiroshi Tomisawa
Keyword(s):  
Novel Synthesis ◽  
Active Methylene Compounds ◽  
Active Methylene

Reaction of Carbon Disulfide with Active Methylenes: Novel Synthesis of Thiophene, Thieno[2,3-b]thiophene, Thieno[3,2-c]pyrazole and Thieno[3,2-b]pyridine Derivatives

1995 ◽  
Vol 60 (9) ◽  
pp. 1578-1586 ◽  
Author(s):  
Rafat M. Mohareb ◽  
Sherif M. Sherif ◽  
Adiba Habashi ◽  
Nadia I. Abdel-Sayed ◽  
Samia S. Osman
Keyword(s):  
Carbon Disulfide ◽  
Potassium Hydroxide ◽  
Dimethyl Formamide ◽  
Pyridine Derivatives ◽  
Novel Synthesis ◽  
Oxobutanoic Acid ◽  
Active Methylene Compounds ◽  
Derivatives Of ◽  
Active Methylene

The active methylene compounds - derivatives of malonic or 4-oxobutanoic acid - reacted with carbon disulfide in dimethyl formamide containing potassium hydroxide to yield the non-isolable dipotassium disulfide intermediates. The latter were cyclized by α-haloketones to give thiophene, thieno[2,3-b]thiophene, thieno[3,2-c]pyrazole and thieno[3,2-b]pyridine derivatives. The reactivity of the products toward various reagents was studied.

scholarly journals Application of Commercially Available Anhydrous Potassium Fluoride for a Convenient Synthesis of Ketene Dithioacetals

1999 ◽  
Vol 23 (8) ◽  
pp. 492-493
Author(s):  
Sabir H. Mashraqui ◽  
Harini Hariharasubrahmanian
Keyword(s):  
Carbon Disulfide ◽  
Alkylating Agent ◽  
Potassium Fluoride ◽  
Solid Support ◽  
Ambient Conditions ◽  
Ketene Dithioacetals ◽  
Convenient Synthesis ◽  
Active Methylene Compounds ◽  
Active Methylene

Commercially available anhydrous KF without activation or solid support promotes condensation between active methylene compounds, carbon disulfide and an alkylating agent in dry DMF to allow the preparation of a variety of ketene dithioacetals in fair to good yields under ambient conditions.

The Copper-catalyzed Chemoselective Monoalkylation of Active Methylene Compounds with Alkylsilyl Peroxides

2021 ◽  
Author(s):  
Jiamin Lv ◽  
Weiping Xu ◽  
Hanbin Lu ◽  
Terumasa Kato ◽  
Yan Liu ◽  
...  
Keyword(s):  
Active Methylene Compounds ◽  
Novel Method ◽  
Active Methylene

A novel method for a mild copper-catalyzed chemoselective monoalkylation of active methylene compounds with various alkylsilyl peroxides has been developed. The reaction has a broad substrate scope and our mechanistic...

scholarly journals A Convenient Method for the Introduction of 1,3-Dithiolan-2-yl Group into Active Methylene Compounds

1978 ◽  
Vol 51 (2) ◽  
pp. 665-666 ◽  
Author(s):  
Shigeo Tanimoto ◽  
Yasuo Matsumura ◽  
Toyonari Sugimoto ◽  
Masaya Okano
Keyword(s):  
Convenient Method ◽  
Active Methylene Compounds ◽  
Active Methylene
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