The relationship of serum alkaline phosphatase levels to stages of pubic hair development

1975 ◽  
Vol 42 (4) ◽  
pp. 313-317 ◽  
Author(s):  
G. M. Hope ◽  
P. G. Dyment
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Pubic Hair ◽  
Hair Development ◽  
Relationship Of ◽  
The Relationship

THE RELATIONSHIP OF DIETARY FACTORS TO RAT SERUM ALKALINE PHOSPHATASE

1952 ◽  
Vol 30 (6) ◽  
pp. 515-519
Author(s):  
Jules Tuba ◽  
Kazie A. Siluch ◽  
Margaret I. Robinson ◽  
Neil B. Madsen
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Dietary Factors ◽  
Sodium Oxalate ◽  
Rat Serum ◽  
Growing Rats ◽  
Calcium And Magnesium ◽  
Relationship Of ◽  
The Relationship ◽  
Normal Calcium

Increased levels of serum alkaline phosphatase were produced in growing rats by diets low in calcium or by the addition of sodium oxalate or rhubarb to diets containing adequate amounts of calcium. In addition, variations from normal in levels of serum phosphorus, calcium, and magnesium, as well as the ash of the tibiae, indicate that the animals were rachitic. The amount of calcium retained in the bodies of animals maintained on a diet containing rhubarb, which has a high oxalate content, were very much lower than in growing rats fed a normal calcium diet.

scholarly journals An association between time-varying serum alkaline phosphatase concentrations and mortality rate in patients undergoing peritoneal dialysis: a five-year cohort study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ying Liu ◽  
Jin-Gang Zhu ◽  
Ben-Chung Cheng ◽  
Shang-Chih Liao ◽  
Chih-Hsiung Lee ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Alkaline Phosphatase ◽  
Peritoneal Dialysis ◽  
Serum Alkaline Phosphatase ◽  
Urine Volume ◽  
Time Dependent ◽  
Time Varying ◽  
Cox Models ◽  
Death Risk ◽  
The Relationship

Abstract The relationship between serum alkaline phosphatase (ALP) concentrations and mortality in peritoneal dialysis (PD) patients is rarely reported. We enrolled 667 PD patients in one PD centre in Taiwan to retrospectively examine the association between three ALP concentrations (baseline, time-averaged, time-dependent) and mortality over a 5-year period (2011–2015). Baseline data collection included demographics, clinical, and laboratory parameters. Multivariable-adjusted Cox models were used to analyse the association. Four ALP quartiles were defined at the baseline: ≤62, 63–82, 83–118, and ≥119 U/L. Of 667 patients, 65 patients died, of which 8 patients died due to cardiovascular disease. Females were predominant in the higher ALP quartiles, and 24-h urine volume was significantly proportionately decreased in the higher ALP quartiles. ALP quartiles expressed by the three models were not associated with all-cause or cardiovascular mortalities after adjusting for demographics, liver function, bone metabolism, mortality, hemoglobin, and 24-h urine volume. In conclusion, ALP concentrations were not associated with death risk in PD patients over the 5-year period.

THE RELATIONSHIP OF DIETARY FACTORS TO RAT SERUM ALKALINE PHOSPHATASE: 1. THE EFFECT OF FAT, METHIONINE, AND CYSTINE

1950 ◽  
Vol 28e (2) ◽  
pp. 41-46 ◽  
Author(s):  
Jules Tuba ◽  
Ridley K. Shaw
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Serum Alkaline Phosphatase ◽  
Dietary Factors ◽  
Rat Serum ◽  
Serum Alkaline Phosphatase Activity ◽  
Weight Losses ◽  
Weanling Rats ◽  
Standard Laboratory Diet ◽  
Relationship Of

In synthetic diets fed to weanling rats, methionine and fat must be present in a definite ratio in order to maintain a serum alkaline phosphatase activity equal to that obtained on a standard laboratory diet of animal checkers. This ratio is approximately 1:25 by weight for a diet containing 8.5% fat. Increased fat enhances, while increased methionine lowers, the serum phosphatase activity. Although in some experiments methionine was fed in concentrations sufficient to lower phosphatase activity to what has been considered definitely subnormal values, growth was good and the general condition of the animals was excellent. However, beyond certain concentrations of the amino acid, food consumption decreased and weight losses occurred. Cystine had no effect in opposing the action of methionine on serum alkaline phosphatase.

scholarly journals Adaptive increase in phytate digestibility by phosphorus-deprived rats and the relationship of intestinal phytase (EC 3.1.3.8) and alkaline phosphatase (EC 3.1.3.1) to phytate utilization

1983 ◽  
Vol 49 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Robert J. Moore ◽  
Trygve L. Veum
Keyword(s):  
Alkaline Phosphatase ◽  
Inositol Phosphates ◽  
Enzymic Hydrolysis ◽  
Intestinal Alkaline Phosphatase ◽  
Alkaline Phytase ◽  
Treatment Groups ◽  
Phosphorus Deprivation ◽  
Relationship Of ◽  
The Relationship ◽  
Hydrolysis Of

1. The effects of phosphorus deprivation on phytate digestibility, phosphorus utilization and intestinal phytase (EC3.1.3.8) and alkaline phosphatase (EC3.1.3.1) in rats were investigated.2. P deprivation was achieved by giving rats a diet containing 3 g P/kg and resulted in hypophosphataemia, hypercalcaemia, hypercalciuria, and lower levels of P absorbed and retained, and calcium retained.3. Rats adapted to P deprivation by increasing the digestion of total dietary-P and phytate-P.4. Levels of intestinal alkaline phosphatase and alkaline phytase were not different between the two treatment groups.5. P deprivation in the rats given the marginal-P diet may be a result of a lower absorption of total dietary-P or increased absorption of inositol phosphates formed during the enzymic hydrolysis of phytate which are not readily utilized by the rat.6. These results suggest that intestinal phytase and alkaline phosphatase do not play a role in the adaptive increase in phytate digestibility by rats given marginal-P diets. The adaptation may result from enhanced phytase or alkaline phosphatase synthesis by the gastrointestinal microflora stimulated by a lower level of P in the digesta.

Relationship of plasma tartrate resistant acid phosphatase to the bone isoenzyme of serum alkaline phosphatase in hyperparathyroidism

1983 ◽  
Vol 133 (2) ◽  
pp. 189-200 ◽  
Author(s):  
J.J. Štěpán ◽  
E. Šilinková-Málková ◽  
T. Havránek ◽  
J. Formánková ◽  
M. Zichová ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Acid Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Tartrate Resistant Acid Phosphatase ◽  
Relationship Of

scholarly journals P0831HIGH SERUM ALKALINE PHOSPHATASE PREDICTS THE RISK OF CKD PROGRESSION: EFFECT NODIFICATION BY THE GFR

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Francesca Mallamaci ◽  
Graziella D'arrigo ◽  
F Marino ◽  
Graziella Caridi ◽  
Giovanna Parlongo ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Normal Range ◽  
Ckd Progression ◽  
Effect Modifier ◽  
End Point ◽  
Traditional Age ◽  
Hs Crp ◽  
Post Hoc ◽  
The Relationship

Abstract Background and Aims In the post-hoc analyses of the SUSTAIN and ASSURE trials (Kidney Blood Press Res. 2018;43:449-457), Apabetalone, an epigenetic modulator which lowers serum alkaline phosphatase (AlkPhos), stabilized the GFR in patients with cardiovascular disease and a GFR <60/ml/min/1.73m2. Analyzing the relationship between AlkPhos and renal outcomes in patients with established CKD is useful to preliminarily explore the biological hypothesis that AlkPhos is implicated in CKD progression. Method We investigated the relationship between AlkPhos and the risk for a combined renal end-point (30% GFR loss or dialysis/renal transplantation) in a cohort of 609 stage 3-5 CKD patients with an average GFR of 34.8±12.1ml/min/1.73 m2. Results Median AlkPhos levels were 91 IU/L (Interquartile range 71-117 IU/L) and in the vast majority of patients had values below 147 IU/L (the upper limit of the normal range). Over a median follow up of 3 years, two-hundred patients had the combined renal end-point. In an unadjusted analysis 1 ln increase in AlkPhos entailed a 49% risk excess for the renal end-point (HR: 1.49, 95% CI 1.11-2.01, P=0.008). Adjusting for traditional (age, gender, smoking, diabetes, total cholesterol, BMI, systolic BP, CV comorbidities) and CKD specific risk factors (hemoglobin, albumin, phosphate, and hs-CRP) did not modify the strength of this association (HR:1.48, 95% CI 1.08-2.02, P=0.016). Furthermore, In a fully adjusted analysis testing the GFR as an effect modifier of the AlkPhos - combined renal end point relationship showed a strong GFR- AlkPhos interaction (Figure). Indeed the risk for the combined renal end-point was gradually more pronounced at progressively more severe degrees of renal dysfunction, the HR being 0.94 (CI95% 0.60-1.47) at a GFR of 40 ml/min/m2 and 2.71 (CI95% 1.49-4.93) at 10 ml/min/1.73m2. Conclusion In patients with stage 3-5 CKD alkaline phosphatase within the normal range is associated with the risk for progression to ESRD and the GFR is an effect modifier of this relationship. Findings in this study are compatible with the hypothesis that within the normal range of this biomarker, the risk for CKD progression by alkaline phosphatase is amplified by the severity of CKD. These data are in keeping with post-hoc analyses of the SUSTAIN and ASSURE trials and provide circumstantial support to the hypothesis that interventions lowering serum alkaline phosphatase may mitigate CKD progression.

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