scholarly journals Modeling selective therapeutic hypothermia in case of acute ischemic stroke using a 1D hemodynamics model and a simplified brain geometry

2020 ◽  
Vol 17 (2) ◽  
pp. 1147-1167
Author(s):  
Yannick Lutz ◽  
◽  
Rosa Daschner ◽  
Lorena Krames ◽  
Axel Loewe ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia

scholarly journals Therapeutic Hypothermia for Acute Ischemic Stroke: Ready to Start Large Randomized Trials?

2010 ◽  
Vol 30 (6) ◽  
pp. 1079-1093 ◽  
Author(s):  
H Bart van der Worp ◽  
Malcolm R Macleod ◽  
Rainer Kollmar ◽  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia ◽  
Animal Studies ◽  
Brain Injuries ◽  
Focal Cerebral Ischemia ◽  
Perinatal Asphyxia ◽  
Phase Iii ◽  
Neuroprotective Strategy ◽  
Critical Issues

Therapeutic hypothermia is a means of neuroprotection well established in the management of acute ischemic brain injuries such as anoxic encephalopathy after cardiac arrest and perinatal asphyxia. As such, it is the only neuroprotective strategy for which there is robust evidence for efficacy. Although there is overwhelming evidence from animal studies that cooling also improves outcome after focal cerebral ischemia, this has not been adequately tested in patients with acute ischemic stroke. There are still some uncertainties about crucial factors relating to the delivery of hypothermia, and the resolution of these would allow improvements in the design of phase III studies in these patients and improvements in the prospects for successful translation. In this study, we discuss critical issues relating first to the targets for therapy including the optimal depth and duration of cooling, second to practical issues including the methods of cooling and the management of shivering, and finally, of factors relating to the design of clinical trials. Consideration of these factors should inform the development of strategies to establish beyond doubt the place of hypothermia in the management of acute ischemic stroke.

Therapeutic Hypothermia in Acute Ischemic Stroke—a Systematic Review and Meta-Analysis

2020 ◽  
Vol 20 (5) ◽  
Author(s):  
Andrea M Kuczynski ◽  
Sina Marzoughi ◽  
Abdulaziz S. Al Sultan ◽  
Frederick Colbourne ◽  
Bijoy K. Menon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia ◽  
Meta Analysis

Therapeutic hypothermia in acute ischemic stroke

2007 ◽  
Vol 7 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Heleen den Hertog ◽  
Bart van der Worp ◽  
Maarten van Gemert ◽  
Diederik Dippel
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia

Therapeutic hypothermia for acute ischemic stroke

2010 ◽  
Vol 8 (4) ◽  
pp. 593-603 ◽  
Author(s):  
Michael T Froehler ◽  
Bruce Ovbiagele
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia

scholarly journals A Trial of Therapeutic Hypothermia via Endovascular Approach in Awake Patients with Acute Ischemic Stroke: Methodology

2006 ◽  
Vol 13 (8) ◽  
pp. 820-827 ◽  
Author(s):  
Kama Z. Guluma ◽  
Thomas M. Hemmen ◽  
Scott E. Olsen ◽  
Karen S. Rapp ◽  
Patrick D. Lyden
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia ◽  
Endovascular Approach

scholarly journals Therapeutic Hypothermia for Acute Ischemic Stroke

Stroke ◽  
2004 ◽  
Vol 35 (6) ◽  
pp. 1482-1489 ◽  
Author(s):  
Derk W. Krieger ◽  
Midori A. Yenari
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia

scholarly journals Therapeutic Hypothermia After Recanalization in Patients With Acute Ischemic Stroke

Stroke ◽  
2014 ◽  
Vol 45 (1) ◽  
pp. 134-140 ◽  
Author(s):  
Ji Man Hong ◽  
Jin Soo Lee ◽  
Hee-Jung Song ◽  
Hye Seon Jeong ◽  
Huimahn Alex Choi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia

Endovascular Therapeutic Hypothermia for Acute Ischemic Stroke: ICTuS 2/3 Protocol

2013 ◽  
Vol 9 (1) ◽  
pp. 117-125 ◽  
Author(s):  
Patrick D. Lyden ◽  
Thomas M. Hemmen ◽  
James Grotta ◽  
Karen Rapp ◽  
Rema Raman
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia
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