scholarly journals A Trial of Therapeutic Hypothermia via Endovascular Approach in Awake Patients with Acute Ischemic Stroke: Methodology

2006 ◽  
Vol 13 (8) ◽  
pp. 820-827 ◽  
Author(s):  
Kama Z. Guluma ◽  
Thomas M. Hemmen ◽  
Scott E. Olsen ◽  
Karen S. Rapp ◽  
Patrick D. Lyden
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia ◽  
Endovascular Approach

Successful recanalization for acute ischemic stroke via the transbrachial approach

2014 ◽  
Vol 8 (2) ◽  
pp. 122-125 ◽  
Author(s):  
Masakazu Okawa ◽  
Satoshi Tateshima ◽  
David Liebeskind ◽  
Latisha K Ali ◽  
Michael L Thompson ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Patient Specific ◽  
Ischemic Stroke Patient ◽  
Transfemoral Approach ◽  
Acute Ischemic Stroke Patient ◽  
Transbrachial Approach ◽  
Stent Retrievers ◽  
Endovascular Approach ◽  
Specific Factors

The recent development of revascularization devices, including stent retrievers, has enabled increasingly higher revascularization rates for arterial occlusions in acute ischemic stroke. Patient-specific factors such as anatomy, however, may occasionally limit endovascular deployment of these new devices via the conventional transfemoral approach. We report three cases of acute ischemic stroke where a transbrachial endovascular approach to revascularization was used, resulting in successful recanalization. These examples suggest that a transbrachial approach may be considered as an alternative in the endovascular treatment of acute ischemic stroke.

scholarly journals Endovascular Intervention for Acute Ischemic Stroke in Light of Recent Trials

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Kenan Alkhalili ◽  
Nohra Chalouhi ◽  
Stavropoula Tjoumakaris ◽  
David Hasan ◽  
Robert M. Starke ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Endovascular Treatment ◽  
Acute Ischemic Stroke ◽  
Treatment Strategies ◽  
Endovascular Intervention ◽  
Treatment Modalities ◽  
Efficacy And Safety ◽  
The Past ◽  
Endovascular Approach

Three recently published trials, MR RESCUE, IMS III, and SYNTHESIS Expansion, evaluating the efficacy and safety of endovascular treatment of acute ischemic stroke have generated concerns about the future of endovascular approach. However, the tremendous evolution that imaging and endovascular treatment modalities have undergone over the past several years has raised doubts about the validity of these trials. In this paper, we review the role of endovascular treatment strategies in acute ischemic stroke and discuss the limitations and shortcomings that prevent generalization of the findings of recent trials. We also provide our experience in endovascular treatment of acute ischemic stroke.

scholarly journals Modeling selective therapeutic hypothermia in case of acute ischemic stroke using a 1D hemodynamics model and a simplified brain geometry

2020 ◽  
Vol 17 (2) ◽  
pp. 1147-1167
Author(s):  
Yannick Lutz ◽  
◽  
Rosa Daschner ◽  
Lorena Krames ◽  
Axel Loewe ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia

scholarly journals Therapeutic Hypothermia for Acute Ischemic Stroke: Ready to Start Large Randomized Trials?

2010 ◽  
Vol 30 (6) ◽  
pp. 1079-1093 ◽  
Author(s):  
H Bart van der Worp ◽  
Malcolm R Macleod ◽  
Rainer Kollmar ◽  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia ◽  
Animal Studies ◽  
Brain Injuries ◽  
Focal Cerebral Ischemia ◽  
Perinatal Asphyxia ◽  
Phase Iii ◽  
Neuroprotective Strategy ◽  
Critical Issues

Therapeutic hypothermia is a means of neuroprotection well established in the management of acute ischemic brain injuries such as anoxic encephalopathy after cardiac arrest and perinatal asphyxia. As such, it is the only neuroprotective strategy for which there is robust evidence for efficacy. Although there is overwhelming evidence from animal studies that cooling also improves outcome after focal cerebral ischemia, this has not been adequately tested in patients with acute ischemic stroke. There are still some uncertainties about crucial factors relating to the delivery of hypothermia, and the resolution of these would allow improvements in the design of phase III studies in these patients and improvements in the prospects for successful translation. In this study, we discuss critical issues relating first to the targets for therapy including the optimal depth and duration of cooling, second to practical issues including the methods of cooling and the management of shivering, and finally, of factors relating to the design of clinical trials. Consideration of these factors should inform the development of strategies to establish beyond doubt the place of hypothermia in the management of acute ischemic stroke.

Therapeutic Hypothermia in Acute Ischemic Stroke—a Systematic Review and Meta-Analysis

2020 ◽  
Vol 20 (5) ◽  
Author(s):  
Andrea M Kuczynski ◽  
Sina Marzoughi ◽  
Abdulaziz S. Al Sultan ◽  
Frederick Colbourne ◽  
Bijoy K. Menon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia ◽  
Meta Analysis

Therapeutic hypothermia in acute ischemic stroke

2007 ◽  
Vol 7 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Heleen den Hertog ◽  
Bart van der Worp ◽  
Maarten van Gemert ◽  
Diederik Dippel
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia

Therapeutic hypothermia for acute ischemic stroke

2010 ◽  
Vol 8 (4) ◽  
pp. 593-603 ◽  
Author(s):  
Michael T Froehler ◽  
Bruce Ovbiagele
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia

scholarly journals Therapeutic Hypothermia for Acute Ischemic Stroke

Stroke ◽  
2004 ◽  
Vol 35 (6) ◽  
pp. 1482-1489 ◽  
Author(s):  
Derk W. Krieger ◽  
Midori A. Yenari
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Therapeutic Hypothermia
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