scholarly journals A note on the global properties of an age-structured viral dynamic model with multiple target cell populations

2017 ◽  
Vol 14 (3) ◽  
pp. 805-820 ◽  
Author(s):  
Shaoli Wang ◽  
◽  
Jianhong Wu ◽  
Libin Rong ◽  
◽  
...  
Keyword(s):  
Dynamic Model ◽  
Target Cell ◽  
Cell Populations ◽  
Multiple Target ◽  
Viral Dynamic ◽  
Global Properties ◽  
Age Structured

scholarly journals A Viral Dynamic Model for Treatment Regimens with Direct-acting Antivirals for Chronic Hepatitis C Infection

2012 ◽  
Vol 8 (1) ◽  
pp. e1002339 ◽  
Author(s):  
Bambang S. Adiwijaya ◽  
Tara L. Kieffer ◽  
Joshua Henshaw ◽  
Karen Eisenhauer ◽  
Holly Kimko ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Dynamic Model ◽  
Chronic Hepatitis C ◽  
Direct Acting Antivirals ◽  
Hepatitis C Infection ◽  
Treatment Regimens ◽  
Viral Dynamic ◽  
Direct Acting

Global properties for an age-structured within-host model with Crowley–Martin functional response

2017 ◽  
Vol 10 (02) ◽  
pp. 1750030 ◽  
Author(s):  
Shaoli Wang ◽  
Xinyu Song
Keyword(s):  
Functional Response ◽  
Viral Infections ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Positive Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Multi Scale ◽  
Global Properties ◽  
Age Structured

Based on a multi-scale view, in this paper, we study an age-structured within-host model with Crowley–Martin functional response for the control of viral infections. By means of semigroup and Lyapunov function, the global asymptotical property of infected steady state of the model is obtained. The results show that when the basic reproductive number falls below unity, the infection dies out. However, when the basic reproductive number exceeds unity, there exists a unique positive equilibrium which is globally asymptotically stable. This model can be deduced to different viral models with or without time delay.

Rapid Convergence to Feature Layer Correspondences

2008 ◽  
Vol 20 (10) ◽  
pp. 2441-2463 ◽  
Author(s):  
Jörg Lücke ◽  
Christian Keck ◽  
Christoph von der Malsburg
Keyword(s):  
Neural Network ◽  
Dynamic Model ◽  
Natural Images ◽  
Cell Populations ◽  
Rapid Convergence ◽  
Time Intervals ◽  
Single Column ◽  
Feature Information ◽  
Experimental Findings ◽  
Dynamic Links

We describe a neural network able to rapidly establish correspondence between neural feature layers. Each of the network's two layers consists of interconnected cortical columns, and each column consists of inhibitorily coupled subpopulations of excitatory neurons. The dynamics of the system builds on a dynamic model of a single column, which is consistent with recent experimental findings. The network realizes dynamic links between its layers with the help of specialized columns that evaluate similarities between the activity distributions of local feature cell populations, are subject to a topology constraint, and can gate the transfer of feature information between the neural layers. The system can robustly be applied to natural images, and correspondences are found in time intervals estimated to be smaller than 100 ms in physiological terms.

Age-Structured Within-Host HIV Dynamics with Multiple Target Cells

2016 ◽  
Vol 138 (1) ◽  
pp. 43-76 ◽  
Author(s):  
Xia Wang ◽  
Yijun Lou ◽  
Xinyu Song
Keyword(s):  
Target Cells ◽  
Multiple Target ◽  
Hiv Dynamics ◽  
Age Structured

scholarly journals A naturally occurring bone marrow-chimeric primate. II. Environment dictates restriction on cytolytic T lymphocyte-target cell interactions.

1985 ◽  
Vol 162 (6) ◽  
pp. 2035-2052 ◽  
Author(s):  
J Picus ◽  
K Holley ◽  
W R Aldrich ◽  
J D Griffin ◽  
N L Letvin
Keyword(s):  
Bone Marrow ◽  
T Lymphocyte ◽  
Target Cell ◽  
Cell Interactions ◽  
Primate Species ◽  
Cell Populations ◽  
Target Cells ◽  
Functional Assay ◽  
Naturally Occurring ◽  
Cytolytic T Lymphocyte

Restriction on cytolytic T lymphocyte (CTL)-target cell-interactions are studied in the primate S. oedipus, a naturally occurring A + B----A bone marrow-chimeric species. We show that the T cell, B cell, and myelomonocytic progenitor cell populations are chimeric in this species. We selected animals for study that are populated by fully major histocompatibility complex (MHC)-disparate hematopoietic cell populations, using a functional assay system. We then developed an in vitro system for analyzing at the clonal level the genetic restrictions on the trinitrophenyl-specific CTL-target cell interactions of this species. In this system, we have shown that tolerance to foreign MHC determinants was not, of itself, sufficient to facilitate the generation of CTL specific for target cells expressing those foreign MHC determinants. Rather, a marked preference for the expansion of CTL clones with a restriction for target cells bearing the host animals' MHC determinants was seen. Hematopoietically derived cells did not affect the repertoire of these T lymphocytes. These studies represent the first demonstration of the phenomenon of an environment dictating interactional restrictions on CTL in a naturally occurring bone marrow-chimeric animal. This is also the first demonstration of the profound influence of the environment on the repertoire of the T lymphocyte in a primate species.

A generic viral dynamic model to systematically characterize the interaction between oncolytic virus kinetics and tumor growth

2017 ◽  
Vol 97 ◽  
pp. 38-46 ◽  
Author(s):  
Melanie I. Titze ◽  
Julia Frank ◽  
Michael Ehrhardt ◽  
Sigrun Smola ◽  
Norbert Graf ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Dynamic Model ◽  
Oncolytic Virus ◽  
Viral Dynamic
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