Protective effects of bilobalide on Aβ25–35 induced learning and memory impairments in male rats

2013 ◽  
Vol 106 ◽  
pp. 77-84 ◽  
Author(s):  
Yanyan Yin ◽  
Yuguo Ren ◽  
Wangyang Wu ◽  
Yuchan Wang ◽  
Mingcheng Cao ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Male Rats ◽  
Protective Effects ◽  
Memory Impairments

The effects of soy on scopolamine-induced spatial learning and memory impairments are comparable to the effects of estradiol

2019 ◽  
Vol 39 (3) ◽  
Author(s):  
Narges Marefati ◽  
Amin Mokhtari-Zaer ◽  
Farimah Beheshti ◽  
Sareh Karimi ◽  
Zahra Mahdian ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Serum Levels ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Spatial Learning And Memory ◽  
Protective Effects ◽  
Memory Impairments ◽  
The Central Nervous System ◽  
Higher Doses

Abstract Background Modulatory effects of soy extract and estradiol on the central nervous system (CNS) have been reported. The effect of soy on scopolamine-induced spatial learning and memory in comparison to the effect of estradiol was investigated. Materials and methods Ovariectomized rats were divided into the following groups: (1) control, (2) scopolamine (Sco), (3) scopolamine-soy 20 (Sco-S 20), (4) scopolamine-soy 60 (Sco-S 60), (5) scopolamine-estradiol 20 (Sco-E 20) and (6) scopolamine-estradiol 60 (Sco-E 60). Soy extract, estradiol and vehicle were administered daily for 6 weeks before training in the Morris water maze (MWM) test. Scopolamine (2 mg/kg) was injected 30 min before training in the MWM test. Results In the MWM, the escape latency and traveled path to find the platform in the Sco group was prolonged compared to the control group (p < 0.001). Treatment by higher doses of soy improved performances of the rats in the MWM (p < 0.05 – p < 0.001). However, treatment with both doses of estradiol (20 and 60 μg/kg) resulted in a statistically significant improvement in the MWM (p < 0.01 – p < 0.001). Cortical, hippocampal and serum levels of malondialdehyde (MDA), as an index of lipid peroxidation, were increased which was prevented by soy extract and estradiol (p < 0.001). Cortical, hippocampal as well as serum levels of the total thiol, superoxide dismutase (SOD) and catalase (CAT) in Sco group were lower than the control group (p < 0.001) while they were enhanced when the animals were treated by soy extract and estradiol (p < 0.01 – p < 0.001). Conclusions It was observed that both soy extract and estradiol prevented learning and memory impairments induced by scopolamine in ovariectomized rats. These effects can be attributed to their protective effects on oxidative damage of the brain tissue.

Protective Effects of Puerarin against Aβ 1–42-Induced Learning and Memory Impairments in Mice

Planta Medica ◽  
2016 ◽  
Vol 83 (03/04) ◽  
pp. 224-231 ◽  
Author(s):  
Lidan Wu ◽  
Tong Tong ◽  
Shutong Wan ◽  
Tingxu Yan ◽  
Fangyi Ren ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Protective Effects ◽  
Memory Impairments
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