Acute Toxicity Potential of Methanolic Extract of Smilax kraussiana Leaves in Rats

2006 ◽  
Vol 2 (4) ◽  
pp. 463-466 ◽  
Author(s):  
Paul A. Nwafor . ◽  
Memfin Ekpo . ◽  
Tony Waka Udezi . ◽  
Jude Okokon . ◽  
Augustine L. Bassey .
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract ◽  
Toxicity Potential

Acute and sub-acute toxicity methanolic extract from Brickellia cavanillesii in mice

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
GM Avila-Villarreal ◽  
DE Giles-Rivas ◽  
B Aguilar-Guadarrama ◽  
P Castillo-España ◽  
S Estrada-Soto
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract

scholarly journals Acute and Sub-Acute Toxicity Evaluation of the Methanolic Extract of Alstonia scholaris Stem Bark

2016 ◽  
Vol 4 (1) ◽  
pp. 4 ◽  
Author(s):  
Idris Bello ◽  
Abdulmenem Bakkouri ◽  
Yasser Tabana ◽  
Bassel Al-Hindi ◽  
Majed Al-Mansoub ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract ◽  
Stem Bark ◽  
Toxicity Evaluation ◽  
Alstonia Scholaris

scholarly journals Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Gaëlle S. Nguenang ◽  
Arsène S. M. Ntyam ◽  
Victor Kuete
Keyword(s):  
Single Dose ◽  
Acute Toxicity ◽  
Lycopersicon Esculentum ◽  
Methanolic Extract ◽  
Female Rats ◽  
Male Rats ◽  
Total Serum ◽  
Subacute Toxicity ◽  
Tomato Extract ◽  
Long Term Treatment

Lycopersicon esculentum (tomato) is a plant widely used in Africa like food and to solve many health problems. The methanol crude extract of tomato recently demonstrated a good antiproliferative effect on many human cancer cell lines. The aim of this research was to evaluate the acute toxicity and subacute oral toxicity of methanolic extract from leaves of this plant. These toxicities were evaluated based on the OECD (Organization for Economic Cooperation and Development) guidelines. The assay of acute toxicity was performed using a total of 3 female rats, which received a single dose of 5000 mg/kg of methanolic extract via oral gavage. For the subacute toxicity study, 32 Wistar rats (males and females) were used. The groups were treated with three different doses of Lycopersicon esculentum methanolic extract (250, 500, and 1000 mg/kg b.w.) for 28 days and the control group received distilled water. The hematological, biochemical, and histopathological studies were performed after the sacrifice. Single dose of tomato extract caused no toxicity up to a dose of 5000 mg/kg body weight; hence, the median lethal dose (DL50) of leaves of this plant was greater than this value. However, lower toxic effects could be manifested in the long-term treatment at the highest dose (1000 mg/kg) because urea level and total serum proteins significantly increased at a dose of 1000 mg/kg with respect to control. The microscopic observation showed no remarkable pathological changes on all organs in the treated groups compared with the control groups of female and male rats. These results demonstrate that single dose of tomato extract leaves is relatively nontoxic at a dose of 5000 mg/kg b.w. and prolonged use of lower doses (250 and 500 mg/kg) of L. esculentum orally should be encouraged, whereas highest dose (1000 mg/kg) should be avoided.

Evaluation of acute toxicity potential of water hyacinth leaves

2012 ◽  
Vol 30 (5) ◽  
pp. 426-431 ◽  
Author(s):  
Wenbiao Wu ◽  
Xiaoguang Guo ◽  
Mingliang Huang
Keyword(s):  
Acute Toxicity ◽  
Water Hyacinth ◽  
Toxicity Potential

Antioxidant and Analgesic Activity of Acer laevigatum Wall, a Traditional Mizo-tribe Medicine

2020 ◽  
Vol 13 (6) ◽  
pp. 5200-5207
Author(s):  
Andrew Lalthasanga Ralte ◽  
Phaibiang Lapasam ◽  
Freddy Teilang Nongkhlaw ◽  
Pdiangmon Kyndait ◽  
Zothanpuia
Keyword(s):  
Antioxidant Activity ◽  
Acute Toxicity ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Bark Extract ◽  
Total Phenolic ◽  
Phytochemical Screening ◽  
External Application ◽  
Soxhlet Apparatus

Acer laevigatum is an evergreen tree growing to a height of 10–15 m or more, with a trunk up to 50 cm diameter belonging to the family Sapindaceae. In Mizoram, the decoction of the leaves is used as an external application in sprains. Extraction was carried out by drying the leaves and barks and extracted by using methanol as solvent using the Soxhlet apparatus. Preliminary phytochemical screening was carried out by methanolic extract of both leaves and barks to determine the chemical constituents present in the plant using a different phytochemical test, acute toxicity for leave and bark extract, in-vitro antioxidant activity and in-vivo analgesic activity of barks extract. Phytochemical screening was performed for both extract and it contains glycoside, saponin, phenol, tannin, flavonoid, and steroid. The antioxidant activity test of the methanolic extract of bark extract was performed successfully. In acute toxicity, the LD50 was found that for more than 2000 mg/kg body weight was safe for further uses. The total phenolic content of the bark extract contains 493 ± 0.23 mg of GAE/g and the total flavonoids content of the bark extract was 220 ± 0.034 mg of QE/g. The IC50 value of DPPH free radical scavenging activity was found to be 86.1211 µg/ml and nitric oxide was 75.9 µg/ml. Whereas, in reducing power it was found that the percentage inhibition was increased with an increase in concentration (increase in concen-tration, percentage inhibition was also increased) and reduced Fe3+ (ferricyanide complex) to Fe2+ (ferrous form). Finally, for in-vivo analgesic activity, 4000 mg/kg was more effective than 2000 mg/kg of the bark extract. These results confirm that the methanolic extract of bark of Acer laevigatum possesses antioxidant activity and non-significant or less analgesic activity.

Evaluation of acute and sub acute hepatotoxic activity of Trichodesma indicum aqueous methanolic extract in mice

2016 ◽  
Vol 2 (1) ◽  
pp. 32-35
Author(s):  
Nadia Perveen ◽  
Khwaja Zafar Ahmed ◽  
Tehseen Irshad ◽  
Nayab Latif ◽  
Zainab Kaleem ◽  
...  
Keyword(s):  
Liver Function ◽  
Acute Toxicity ◽  
Marked Effect ◽  
Methanolic Extract ◽  
Maximum Dose ◽  
Toxicity Study ◽  
Subacute Toxicity ◽  
Swiss Mice ◽  
Whole Plant ◽  
Histopathological Studies

Objective: Present study was carried out to evaluate acute and subacute hepatotoxicity of Trichodesma indicum (whole plant). Methods: Toxicity study of Trichodesma indicum was carried out in Swiss mice after ingestion of the aqueous methanolic extract, during one day (acute toxicity) and after fifteen days (subacute toxicity). Results: The results showed that the LD50 of the extract was higher than 4000 mg/kg and subacute treatment showed no change in weight of the liver and ALT, ALP, AST, no marked effect on bilirubin, albumin, protein decreased and globulin values increased significantly. Histopathological studies also showed necrosis and excessive vacuolation in maximum dose. Conclusion: So, the extract showed a ladder like dose related hepatotoxicity. This showed that liver function showed mild injury by Trichodesma indicum in this study.

Evaluation of Acute, Subacute and LD50 values of Methanolic extract of Sphaeranthus indicus leaves in Albino mice

2021 ◽  
pp. 2487-2492
Author(s):  
Gajendra Pratap Choudhary ◽  
Ashutosh Pal Jain
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Biochemical Parameters ◽  
Methanolic Extract ◽  
The Body ◽  
Therapeutic Window ◽  
System Response ◽  
Acute Administration ◽  
Sphaeranthus Indicus ◽  
Hematological And Biochemical Parameters

Sphaeranthus indicus is one of the extremely precious herbs in the Indigenous System of Medicine. The present study was carried out to acute, subacute and LD50 values of methanolic extract of S. indicus leaves in Swiss mice of both sexes. The acute toxicity studies were conducted oral administration of 1.75, 5.5, 17.5, 55, 175, 550, 2000mg/kg body weight SIME used. Observations were recorded systemically up to 24 h after dose administration for behavior related to nervous system response or autonomic functions. Food and water intake, body weight variations, hematological and biochemical parameters were assessed. In sub acute toxicity treatment there were no significant variation in the body weights and haematological parameters except dose-dependent increase in lymphocyte count was noted in both sexes supported immunostimulant activity. Pathologically, significant protective effect on hepatic, renal functions and decreased cholesterol, triglyceride levels. The results did not show any treatment related abnormalities in terms of hematological and biochemical parameters in sub-acute toxicity. After acute administration, no mortality was recorded in mice treated with the SIME orally at a dose of 1000mg/kg. The LD50 values were determined using graphical method; we found a broad therapeutic window and a high therapeutic index value showed that the LD50 of the extract is 2480mg/kg. The results suggest that the plant seems to be high margin of drug safety in mice.

scholarly journals Research on Acute Toxicity and the Behavioral Effects of Methanolic Extract from Psilocybin Mushrooms and Psilocin in Mice

Toxins ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 1018-1029 ◽  
Author(s):  
Olga Zhuk ◽  
Izabela Jasicka-Misiak ◽  
Anna Poliwoda ◽  
Anastasia Kazakova ◽  
Vladlena Godovan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract ◽  
Behavioral Effects
Sign in / Sign up

Export Citation Format

Share Document