Acute and Subchronic (28-day) Oral Toxicity Studies of the Aqueous Root Extract of Securidaca longepedunculata Fresen (Polygalaceae) in Mice

2006 ◽  
Vol 2 (4) ◽  
pp. 421-425 ◽  
Author(s):  
E.U. Etuk . ◽  
R.A. Adebiyi . ◽  
A.T. Elsa . ◽  
B.M. Agaie .
Keyword(s):  
Root Extract ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Aqueous Root Extract ◽  
Securidaca Longepedunculata

scholarly journals Acute and Subchronic Oral Toxicity Evaluation of Aqueous Root Extract ofDicoma anomalaSond. in Wistar Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Fatai Oladunni Balogun ◽  
Anofi Omotayo Tom Ashafa
Keyword(s):  
Clinical Signs ◽  
Toxicity Testing ◽  
Blood Chemistry ◽  
Root Extract ◽  
Toxicity Evaluation ◽  
Oral Toxicity ◽  
Subchronic Toxicity ◽  
Toxicity Studies ◽  
Significant Difference ◽  
Aqueous Root Extract

The present study evaluated the safety of aqueous root extract ofDicoma anomala(AQRED) through acute and subchronic toxicity studies. Single oral dose of AQRED at the concentration of 0, 5, 300, and 2000 mg/kg as well as 125, 250, and 500 mg/kg/day was administered to rats for 14-day acute and 90-day subchronic oral toxicity studies. The results revealed no mortalities or observed clinical signs of toxicity in all the rats during both investigation periods. In subchronic toxicity testing, administration of AQRED also did not cause any changes in body weight as well as food and water consumption patterns. The haematological parameters and blood chemistry revealed no significant difference (p>0.05) between the treatment and the control except in platelet count, alkaline phosphatase, and sodium levels where there was a significant increase (p<0.05), although there was also a significant reduction (p<0.05) in alanine transaminase, aspartate transaminase, and creatinine when compared to control. However, these changes were not reflecting the results from histology. Conclusively, the obtained results suggested that the LD50of AQRED is in excess of 2000 mg/kg and its oral administration for 90 days revealed that it is unlikely to be toxic, hence, safe.

Evaluation of acute and sub-acute oral toxicity of ethanolic root extract of Tetracera akara (Burm. f.) Merr., an ethnomedicinal plant used by the Kani tribe of Kerala

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
Ragesh R Nair
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Root Extract ◽  
Oral Toxicity ◽  
Swiss Albino Mice ◽  
Toxicity Studies ◽  
Biochemical Profiles ◽  
Albino Mice ◽  
Group Sex

The aim of the study was to evaluate the acute oral and sub-acute toxicity of ethanolic root extract of Tetracera akara in Swiss albino mice and Wistar rats. Tetracera akara (Burm. f.) Merr. has been used as traditional medicine by the Kani tribe of Kerala to cure liver diseases. In acute toxicity studies, four groups of mice (n = 5/group/sex) were orally treated with doses of 0.625 g, 1.25 g, 2.5 g and 5.0 g/kg and mortality were recorded. In the sub-acute toxicity study, animals received T. akara extract at the doses of 0.1 g, 0.5 g and 2.5 g/kg/day (n = 5/group/sex) for 28 days, biochemical, hematological, morphological and histopathological parameters were determined. T. akara did not produce any mortality in the acute toxicity studies, showing LD50 higher than 5 g/kg. Sub-acute treatment with T. akara didn’t cause any changes in body weight gain, hematological, biochemical profiles when compared to normal control. In addition, no changes in morphological and histopathological aspect of organs were observed in the animals. Taking all factors into consideration, administration of Tetracera akara does not produce acute toxicity in Swiss albino mice or sub-acute toxicity in Wistar rats, suggesting it’s safe use by humans.

Anticonvulsant, anxiolytic and sedative activities of the aqueous root extract of Securidaca longepedunculata Fresen.

2010 ◽  
Vol 130 (2) ◽  
pp. 191-195 ◽  
Author(s):  
O.O. Adeyemi ◽  
A.J. Akindele ◽  
O.K. Yemitan ◽  
F.R. Aigbe ◽  
F.I. Fagbo
Keyword(s):  
Root Extract ◽  
Aqueous Root Extract ◽  
Securidaca Longepedunculata

scholarly journals Safety and Fertility Potential of Kenyan Grewia tenax (Mukawa Wa Guba) Root Extract Secondary Metabolites

2020 ◽  
pp. 17-23
Author(s):  
Peter J. Kasyoki ◽  
Catherine K. Kaingu ◽  
Christine O. Wangia ◽  
Faraj O. Alkizim
Keyword(s):  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Study Design ◽  
Cardiac Glycosides ◽  
Albino Rats ◽  
Root Extract ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Grewia Tenax

Aim: To screen Kenyan Grewia tenax root extract phytochemicals and correlate the attribute fertility enhancing effects and safety in female albino rats. Study Design: An experimental study design was used. Place and Duration of Study: The phytochemical studies were done at Jomo Kenyatta University of Agriculture and Technology (JKUAT), Department of Botany Laboratory, while acute oral toxicity studies were done at the Department of Veterinary Anatomy and Physiology, University of Nairobi (UON) animal house. The study was done during the month of March to June 2019. Methodology: Grewia tenax was harvested with the help of a plant taxonomist. The roots were chopped into small pieces and dried under shade for three weeks. They were then ground into powder. Organic extracts were prepared by sequential extraction (petroleum ether, dichloromethane (DCM), ethyl acetate and methanol), by use of cold maceration. Aqueous extracts were obtained by hot maceration. Phytochemical screening of extracts was done by standard phytochemical procedures. A total of 12 female albino rats were used in acute oral toxicity studies as per OECD 423 guidelines. Results: Methanol extract had the highest composition of phytochemicals, i.e. alkaloids, flavonoids, saponins, sterols, terpenes and cardiac glycosides. Aqueous and DCM extracts showed presence of alkaloids, saponins and cardiac glycosides, while petroleum ether and ethyl acetate extracts showed presence of alkaloids and cardiac glycosides. Steroids and tannins were absent in all extracts. Flavonoids, alkaloids and terpenes are fertility enhancing compounds due to their antioxidant and radical scavenging properties. Flavonoids, alkaloids and glycosides improve fertility by inducing ovarian steroidogenesis and folliculogenesis. In the acute oral toxicity study, there were no adverse effects at 5000 mg/kg extract administration. Conclusion: Kenyan Grewia tenax root extract has phytochemicals postulated to enhance fertility and is orally safe. These findings may require further verification using in vivo studies.

scholarly journals ACUTE AND SUB-ACUTE ORAL TOXICITY STUDIES OF AQUEOUS EXTRACT OF SECURIDACA LONGEPEDUNCULATA FRESEN (POLYGALACEAE) ROOT BARKS IN RODENTS.

2016 ◽  
Vol 4 (12) ◽  
pp. 550-558 ◽  
Author(s):  
Almamy Konate ◽  
◽  
GeoffroyG. Ouedraogo ◽  
Sylvain Ilboudo ◽  
Noufou Ouedraogo ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Securidaca Longepedunculata

Protective activities of the aqueous root extract of Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
AA Adeneye ◽  
JA Olagunju ◽  
SO Elias ◽  
OD Olatunbosun ◽  
AO Mustafa ◽  
...  
Keyword(s):  
Root Extract ◽  
Aqueous Root Extract

Acute and chronic toxicity studies on Polygonum glabrum in experimental animals

2020 ◽  
Vol 3 (1) ◽  
pp. 7-10
Author(s):  
Saravanakumar A ◽  
Gandhimathi R
Keyword(s):  
Chronic Toxicity ◽  
Clinical Stage ◽  
Herbal Medicines ◽  
Plant Roots ◽  
Root Extract ◽  
Experimental Animals ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity ◽  
Diuretic Agents

Polygonum glabrum is being used in traditional and folklore medicine to treat pneumonia and jaundice. Plant roots are used in ayurvedic preparations to treat fever and colic. The leaves are used as diuretic agents and process vermifuge action. Plant decoction is also used in the treatment of Rheumatism. Besides having many uses and folklore claims, herbal medicines are to be thoroughly investigated for their toxicity also. Therefore this work is being carried out to examine the toxicity of the drug and established dose is safe to use in the clinical stage. The current research studied the acute and chronic toxicity of Polygonum glabrum root extract in rats. It is proved that there was no change in any parameter tested both in acute and chronic toxicity, which means the extract is safe and non-toxic at the dose of 2g/kg also.

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