The Anti-inflammatory Activity of the Foeniculum vulgare L. Essential Oil and Investigation of its Median Lethal Dose in Rats and Mice

2005 ◽  
Vol 1 (4) ◽  
pp. 329-331 ◽  
Author(s):  
Hanefi Ozbek .
Keyword(s):  
Essential Oil ◽  
Lethal Dose ◽  
Inflammatory Activity ◽  
Foeniculum Vulgare ◽  
Median Lethal Dose ◽  
Anti Inflammatory ◽  
Rats And Mice

scholarly journals Anti-Inflammatory Activity of Hydroxydihydrocarvone

2010 ◽  
Vol 65 (9-10) ◽  
pp. 543-550 ◽  
Author(s):  
Reinaldo N. de Almeida ◽  
Damião P. de Sousa ◽  
Enilton A. Camargo ◽  
Fernando S. Oliveira
Keyword(s):  
Motor Coordination ◽  
Lethal Dose ◽  
Treated Group ◽  
Immersion Test ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Rat Paw Edema ◽  
Tail Immersion ◽  
Anti Inflammatory ◽  
Rats And Mice

Hydroxydihydrocarvone (HC) is a synthetic intermediate obtained by hydration of the natural compound (R)-(-)-carvone. The aim of the present study was to investigate the possible anti-inflammatory activity of orally administered HC. Toxicity, motor coordination, tail immersion test, as well as carrageenan-induced paw edema and myeloperoxidase (MPO) activity or peritonitis were all evaluated in rodents. HC was force-fed to the animals 1 h before the stimulus. The lethal dose 50% (LD50) of orally administered HC was 1259 mg/kg. No changes in motor coordination were recorded in HC-treated mice in the rotarod test. The time of response to the thermoceptive stimulus in the tail immersion test was longer in HC-treated animals (50, 100, and 200 mg/kg) than in the vehicle-treated group. HC also significantly decreased the area under curve of carrageenan-induced rat paw edema at 100 and 200 mg/kg and MPO activity at 200 mg/kg. Carrageenan-induced neutrophil recruitment to the peritoneal cavity was significantly reduced by HC at doses of 100 or 200 mg/kg, but not 50 mg/kg. These findings demonstrate that orally administered HC exerts antinociceptive and anti-inflammatory activities in rats and mice.

Evaluation of Median Lethal Dose and Analgesic Activity of Foeniculum vulgare Miller Essential Oil

2006 ◽  
Vol 2 (2) ◽  
pp. 181-183 ◽  
Author(s):  
Hanefi Ozbek ◽  
Abuzer Tas . ◽  
Fevzi Ozgokce . ◽  
Nilufer Selcuk . ◽  
Sevket Alp . ◽  
...  
Keyword(s):  
Essential Oil ◽  
Analgesic Activity ◽  
Lethal Dose ◽  
Foeniculum Vulgare ◽  
Median Lethal Dose ◽  
Foeniculum Vulgare Miller

Anti-inflammatory activity of essential oil of an endemicThymus fontanesiiBoiss. & Reut. with chemotype carvacrol, and its healing capacity on gastric lesions

2017 ◽  
Vol 41 (3) ◽  
pp. e12359 ◽  
Author(s):  
Lilia Mouhi ◽  
Houria Moghrani ◽  
Noureddine Nasrallah ◽  
Abdeltif Amrane ◽  
Rachida Maachi
Keyword(s):  
Essential Oil ◽  
Inflammatory Activity ◽  
Gastric Lesions ◽  
Anti Inflammatory

scholarly journals Essential Oil of Myrtus communis Inhibits Inflammation in Rats by Reducing Serum IL-6 and TNF-α

2011 ◽  
Vol 6 (10) ◽  
pp. 1934578X1100601 ◽  
Author(s):  
Andrea Maxia ◽  
Maria Assunta Frau ◽  
Danilo Falconieri ◽  
Manvendra Singh Karchuli ◽  
Sanjay Kasture
Keyword(s):  
Essential Oil ◽  
Inflammatory Activity ◽  
Myrtus Communis ◽  
Ear Edema ◽  
Tnf Α ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Necrosis Factor ◽  
Serum Tumor Necrosis

The topical anti-inflammatory activity of the essential oil of Myrtus communis L. was studied using croton oil induced ear edema and myeloperoxidase (MPO) activity in mice, and cotton pellet induced granuloma, and serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats. On topical application, the oil exhibited a significant decrease in the ear edema as well as MPO activity. The oil also inhibited cotton pellet-induced granuloma and serum TNF-α and IL-6. It can be concluded that the essential oil of Myrtus communis reduces leukocyte migration to the damaged tissue and exhibits anti-inflammatory activity.

Anti-edematogenic and anti-inflammatory activity of the essential oil from Croton rhamnifolioides leaves and its major constituent 1,8-cineole (eucalyptol)

2017 ◽  
Vol 96 ◽  
pp. 384-395 ◽  
Author(s):  
Anita Oliveira Brito Pereira Bezerra Martins ◽  
Lindaiane Bezerra Rodrigues ◽  
Francisco Rafael Alves Santana Cesário ◽  
Maria Rayane Correia de Oliveira ◽  
Cicera Datiane Morais Tintino ◽  
...  
Keyword(s):  
Essential Oil ◽  
Inflammatory Activity ◽  
Major Constituent ◽  
Anti Inflammatory

scholarly journals The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity

Foods ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 37 ◽  
Author(s):  
Inga Matulyte ◽  
Aiste Jekabsone ◽  
Lina Jankauskaite ◽  
Paulina Zavistanaviciute ◽  
Vytaute Sakiene ◽  
...  
Keyword(s):  
Essential Oil ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Inflammatory Activity ◽  
Poly I:C ◽  
Bioactive Substances ◽  
Myristica Fragrans ◽  
Anti Inflammatory ◽  
Nutmeg Essential Oil

Nutmeg (Myristica fragrans) essential oil has antimicrobial, antiseptic, antiparasitic, anti-inflammatory, and antioxidant properties. We have recently demonstrated that hydrodistillation of nutmeg essential oil by applying magnesium aluminometasilicate as an excipient significantly increases both the content and amount of bioactive substances in the oil and hydrolats. In this study, we aimed to compare the antioxidant, antimicrobial, and anti-inflammatory activity of hydrolats and essential oil obtained by hydrodistillation in the presence and absence of magnesium aluminometasilicate as an excipient. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method revealed that magnesium aluminometasilicate did not significantly improved antioxidant activity of both essential oil and hydrolat. Antibacterial efficiency was evaluated by monitoring growth of 15 bacterial strains treated by a range of dilutions of the essential oil and the hydrolats. Essential oil with an excipient completely inhibited the growth of E. faecalis, S. mutans (referent), and P. multocida, whereas the pure oil was only efficient against the latter strain. Finally, the anti-inflammatory properties of the substances were assessed in a fibroblast cell culture treated with viral dsRNR mimetic Poly I:C. The essential oil with an excipient protected cells against Poly I:C-induced necrosis more efficiently compared to pure essential oil. Also, both the oil and the hydrolats with aluminometasilicate were more efficient in preventing IL-6 release in the presence of Poly I:C. Our results show that the use of magnesium aluminometasilicate as an excipient might change and in some cases improve the biological activities of nutmeg essential oil and hydrolats.

scholarly journals Preliminary Analysis of the Anti-Inflammatory Activity of Essential Oils of Zingiber zerumbet

2010 ◽  
Vol 13 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Z. A. Zakaria ◽  
A. S. Mohamad ◽  
M. S. Ahmad ◽  
A. F. Mokhtar ◽  
D. A. Israf ◽  
...  
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Preliminary Analysis ◽  
Formalin Test ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Zingiber Zerumbet ◽  
Cotton Pellet ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-inflammatory agents with few, or no, side effects. Natural products of plant, animal, or microorganism origin have been good sources of new bioactive compounds. The present study was carried out to evaluate the acute and chronic anti-inflammatory activities of the essential oil of the rhizomes of Zingiber zerumbet (Zingiberaceae) using the carrageenan-induced paw edema and cotton pellet-induced granuloma tests, respectively. The effect of the essential oil on inflammatory- and noninflammatory-mediated pain was also assessed using the formalin test. Essential oil of Z. zerumbet, at doses of 30, 100, and 300 mg/kg, was administered intraperitoneally to rats. The substance exhibited significant anti-inflammatory activity both in acute and chronic animal models. The essential oil also inhibited inflammatory- and noninflammatory-mediated pain when assessed using the formalin test. In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments.

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