scholarly journals A Case of Bile Duct Metastasis of Gastric Cancer Developed 7 Years after Curative Operation

2018 ◽  
Vol 79 (1) ◽  
pp. 90-95
Author(s):  
Shohei TAKAICHI ◽  
Kenji SAKAI ◽  
Nobutaka HATANAKA ◽  
Takafumi HIRAO ◽  
Hideki OSAWA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Bile Duct ◽  
Curative Operation

scholarly journals Clincal evaluation of tumor detection of tumor marker following curative operation for gastric cancer.

1989 ◽  
Vol 22 (9) ◽  
pp. 2217-2222
Author(s):  
Tetsuji YAMADA ◽  
Yoshihiro MORI ◽  
Susumu KITAGAWA ◽  
Sakae IWAGAMI ◽  
Kazuo NISHIURA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Marker ◽  
Tumor Detection ◽  
Curative Operation

Prognostic value of duodenal invasion length in patients with gastric cancer.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 24-24
Author(s):  
N. Oshima ◽  
M. Tokunaga ◽  
Y. Tanizawa ◽  
E. Bando ◽  
T. Kawamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Cancer Patients ◽  
Curative Resection ◽  
R0 Resection ◽  
Resection Rate ◽  
Direct Invasion ◽  
Curative Operation ◽  
Duodenal Invasion ◽  
Gastric Cancer Patients

24 Background: Duodenal invasion (DI) has been considered as a poor prognostic factor of gastric cancer patients. Not all the patients would be able to undergo curative operation. Neoadjuvant chemotherapy (NAC) may improve the rate of curative operation of these patients. In this study, we investigated whether the length of duodenal invasion preoperative diagnosis can be one of factor to decide indication of NAC. Methods: A total of 118 gastric cancer patients with clinically evident DI, who underwent laparotomy at our center, were enrolled in this study. 42 patients with DI length 20 mm or longer were categorized into long invasion group (LI), 76 patients with DI length shorter than 20 mm were categorized into short invasion group (SI). Clinicopathologic features, rate of direct invasion and lymph nodes involvement, R0 resection, and survival rate were compared between two groups. Results: Resection rate was significantly different between two groups: SI group (85.5%; 65/76), LI group (69.0%; 29/42). Direct invasion to adjacent organs was significantly more frequently observed in LI group (21%; 6/29) than SI group (4 %; 3/65, p = 0.02). In LI group, pancreas invasion was observed in all patients except for one patient. Multivariate analysis to predict the adjacent organ invasion revealed that CT diagnosis (p = 0.005) and invasion length (p = 0.01) were selected as risk factors of direct invasion to adjacent organs. There was no significant difference of nodal involvement between LI group (83%; 24/29) and SI group (83%; 54/65 p = 0.99). The 5-year survival rate was 19% in LI group and 43% in SI group (p = 0.23). The number of patients who underwent R0 resection was more frequently in SI group (75.4%; 49/65) than SI group (69.1%; 16/29). The factors of R1 or R2 resection were metastasis of peritoneum or direct invasion to adjacent organs. Conclusions: In patients with long duodenal invasion, direct invasion to the pancreas was more frequently observed, and resulted in low curative resection rate and poor survival. Preoperative chemotherapy may improve the curative resection rate and survival in these patients. Prospective study is warranted to evaluate the efficacy of NAC for these patients. No significant financial relationships to disclose.

Association of tumor mutational burden with age in solid tumors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13590-e13590
Author(s):  
Zhuang Yu ◽  
Jing Wang ◽  
Lingxin Feng ◽  
Xue Yang ◽  
Qi Qi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Lung Cancer ◽  
Pancreatic Cancer ◽  
Bile Duct ◽  
Liver Cancer ◽  
Solid Tumors ◽  
Bile Duct Cancer ◽  
Cancer Type ◽  
Duct Cancer

e13590 Background: Immunotherapy is becoming one of the promising treatments for cancer administration, and several studies indicated a better outcome was received in patients with high tumor mutation burden (TMB). The distribution of TMB is still unknown and this study aimed to analysis the association between TMB and age especially in East Asian populations. Methods: In our study, TMB value was measured as the numbers of synonymous, nonsynonymous mutations and InDels by next generation sequencing with 539 genes panel in tumor tissue. TMB-H was defined as highest mutation load quintile (top 20%) in each cancer type. The association between TMB and age in 874 patients was investigated including 174 patients with liver cancer, 32 patients with bile duct cancer, 54 patients with gastric cancer, 119 patients with colorectal cancer, 27 patients with pancreatic cancer, 32 patients with melanoma, 25 patients with glioma and 411 patients with lung cancer cases, respectively. Spearman rank correlation analysis, Mann-Whitney U-test and Fisher’s exact test were used for statistical analysis. Results: A significant correlation between TMB and ages was observed in patients with solid tumors (r = 0.204, p = 1.263×10−9). The median age of included patients was 60 years-old. Based on nonparametric test, the value of TMB in patients with liver cancer ( p = 2.310×10−4), gastric cancer ( p = 0.029) and lung cancer ( p = 0.001) aged ≥ 60 years-old was significantly higher than the corresponding patients aged < 60 years-old. No significant differences of TMB values were found between patients < 60 and ≥ 60 years-old in bile duct cancer ( p = 0.419), colorectal cancer ( p = 0.075), pancreatic cancer ( p = 1), melanoma ( p = 0.952) and glioma ( p = 0.720). The TMB-H ratio in patients with liver ( p = 0.049) and gastric ( p = 0.015) cancer aged < 60 years old was significantly lower than patients aged ≥ 60 years-old. Conclusions: Our study indicated the TMB value and TMB-H ratio were relatively higher with ages ≥ 60 years old in specific tumors, which might provide useful information to guide precisely the the application of PD-1 or PD-L1 inhibitors. As a retrospective study with a relatively small population, the conclusions of this study needed to be verified with a larger sample.

scholarly journals Intrahepatic bile duct adenoma in a patient with gastric cancer

2018 ◽  
Vol 8 (1) ◽  
pp. 7-11
Author(s):  
Tsutomu Namikawa ◽  
Sachi Tsuda ◽  
Kazune Fujisawa ◽  
Eri Munekage ◽  
Jun Iwabu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Bile Duct ◽  
Intrahepatic Bile Duct ◽  
Bile Duct Adenoma

scholarly journals ADENOSQUAMOUS CELL CARCINOMA OF THE BILE DUCT WITH AN EARLY GASTRIC CANCER-A CASE REPORT-

1994 ◽  
Vol 55 (1) ◽  
pp. 192-197
Author(s):  
Takanori WATANABE ◽  
Tadashi NOMIZU ◽  
Takehiro NAGASAWA ◽  
Keiichi ANZAI ◽  
Atsuo TSUCHIYA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Bile Duct ◽  
Early Gastric Cancer ◽  
Cell Carcinoma
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