scholarly journals A RESECTED CASE OF TRIPLE CANCER INVOLVING INTRADUCTAL PAPILLARY MUCINOUS ADENOCARCINOMA OF PANCREAS, BILE DUCT CANCER, AND GASTRIC CANCER IN AN AGED PERSON

2004 ◽  
Vol 65 (12) ◽  
pp. 3344-3349 ◽  
Author(s):  
Kenji MIZUNO ◽  
Tomoyuki YOSHIYAMA ◽  
Hideki AOKI ◽  
Shigehiro SHIOZAKI ◽  
Motoki NINOMIYA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Bile Duct ◽  
Mucinous Adenocarcinoma ◽  
Bile Duct Cancer ◽  
Aged Person ◽  
Duct Cancer ◽  
Triple Cancer ◽  
Resected Case

scholarly journals A CASE REPORT OF METACHRONOUS TRIPLE CANCER-(GASTRIC CANCER, GALLBLADDER CANCER, COMMON BILE DUCT CANCER)-

1997 ◽  
Vol 58 (12) ◽  
pp. 3015-3019
Author(s):  
Masatoshi ISHIZAKI ◽  
Norio AKIYAMA ◽  
Hiroyuki KATO ◽  
Hajime SASAMOTO ◽  
Hidenobu OSAWA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Gallbladder Cancer ◽  
Bile Duct Cancer ◽  
Common Bile Duct Cancer ◽  
Duct Cancer ◽  
Triple Cancer

Association of tumor mutational burden with age in solid tumors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13590-e13590
Author(s):  
Zhuang Yu ◽  
Jing Wang ◽  
Lingxin Feng ◽  
Xue Yang ◽  
Qi Qi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Lung Cancer ◽  
Pancreatic Cancer ◽  
Bile Duct ◽  
Liver Cancer ◽  
Solid Tumors ◽  
Bile Duct Cancer ◽  
Cancer Type ◽  
Duct Cancer

e13590 Background: Immunotherapy is becoming one of the promising treatments for cancer administration, and several studies indicated a better outcome was received in patients with high tumor mutation burden (TMB). The distribution of TMB is still unknown and this study aimed to analysis the association between TMB and age especially in East Asian populations. Methods: In our study, TMB value was measured as the numbers of synonymous, nonsynonymous mutations and InDels by next generation sequencing with 539 genes panel in tumor tissue. TMB-H was defined as highest mutation load quintile (top 20%) in each cancer type. The association between TMB and age in 874 patients was investigated including 174 patients with liver cancer, 32 patients with bile duct cancer, 54 patients with gastric cancer, 119 patients with colorectal cancer, 27 patients with pancreatic cancer, 32 patients with melanoma, 25 patients with glioma and 411 patients with lung cancer cases, respectively. Spearman rank correlation analysis, Mann-Whitney U-test and Fisher’s exact test were used for statistical analysis. Results: A significant correlation between TMB and ages was observed in patients with solid tumors (r = 0.204, p = 1.263×10−9). The median age of included patients was 60 years-old. Based on nonparametric test, the value of TMB in patients with liver cancer ( p = 2.310×10−4), gastric cancer ( p = 0.029) and lung cancer ( p = 0.001) aged ≥ 60 years-old was significantly higher than the corresponding patients aged < 60 years-old. No significant differences of TMB values were found between patients < 60 and ≥ 60 years-old in bile duct cancer ( p = 0.419), colorectal cancer ( p = 0.075), pancreatic cancer ( p = 1), melanoma ( p = 0.952) and glioma ( p = 0.720). The TMB-H ratio in patients with liver ( p = 0.049) and gastric ( p = 0.015) cancer aged < 60 years old was significantly lower than patients aged ≥ 60 years-old. Conclusions: Our study indicated the TMB value and TMB-H ratio were relatively higher with ages ≥ 60 years old in specific tumors, which might provide useful information to guide precisely the the application of PD-1 or PD-L1 inhibitors. As a retrospective study with a relatively small population, the conclusions of this study needed to be verified with a larger sample.

scholarly journals Pathogens and Carcinogenesis: A Review

Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 533
Author(s):  
Muhammad Nur Adam Hatta ◽  
Ezanee Azlina Mohamad Hanif ◽  
Siok-Fong Chin ◽  
Hui-min Neoh
Keyword(s):  
Gastric Cancer ◽  
Bile Duct ◽  
Liver Cancer ◽  
Bile Duct Cancer ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
International Agency ◽  
Damage Initiation ◽  
Group I ◽  
Duct Cancer

Cancer is a global health problem associated with genetics and unhealthy lifestyles. Increasingly, pathogenic infections have also been identified as contributors to human cancer initiation and progression. Most pathogens (bacteria, viruses, fungi, and parasites) associated with human cancers are categorized as Group I human carcinogens by the International Agency for Research on Cancer, IARC. These pathogens cause carcinogenesis via three known mechanisms: persistent infection that cause inflammation and DNA damage, initiation of oncogene expression, and immunosuppression activity of the host. In this review, we discuss the carcinogenesis mechanism of ten pathogens, their implications, and some future considerations for better management of the disease. The pathogens and cancers described are Helicobacter pylori (gastric cancer), Epstein-Barr virus (gastric cancer and lymphoma), Hepatitis B and C viruses (liver cancer), Aspergillus spp. (liver cancer), Opisthorchis viverrine (bile duct cancer), Clonorchis sinensis (bile duct cancer), Fusobacterium nucleatum (colorectal cancer), Schistosoma haematobium (bladder cancer); Human Papillomavirus (cervical cancer), and Kaposi’s Sarcoma Herpes Virus (Kaposi’s sarcoma).

Analysis of microsatellite instability differences in eight types of tumors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15174-e15174
Author(s):  
Zhen Zhang ◽  
Xing Zhang ◽  
Minhui Ge ◽  
Huijuan Qin
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Lung Cancer ◽  
Pancreatic Cancer ◽  
Bile Duct ◽  
Liver Cancer ◽  
Bile Duct Cancer ◽  
Human Cancer ◽  
Exact Test ◽  
Duct Cancer

e15174 Background: Microsatellite instability-high (MSI-H) is the gain or loss of nucleotides from repetitive DNA caused by genomic hypermutability and a powerfully predictive phenotype for diagnosis, immunotherapy and prognosis in various types of cancer. Herein, we analyze the frequency of MSI-H for the understanding of epidemiology of MSI-H across major types of human cancer. Methods: MSI value was calculated by bioinformatics algorithm based on NGS from 539 genes panel in tumor tissue. Patients were divided into three classes as MSI-H, MSI-L and MSS based on MSI value. MSI-H was defined as above 10% positive of the 195 tested microsatellites sites, and this method was totally consistent with conventional MSI-PCR testing in research and development sample verification. We compared the differences of MSI-H ratio in eight types of human cancer including liver cancer, bile duct cancer, gastric cancer, colorectal cancer, pancreatic cancer, melanoma, glioma and lung cancer from 874 cancer cases via χ2 test, adjusted standardized residual or Fisher's exact test. Results: The ratios of MSI-H in eight types of solid tumors were 0% in 32 patients with bile duct cancer or 27 patients with pancreatic cancer, 0.6% (1/174) in liver cancer, 1.9% (1/54) in gastric cancer, 6.7% (8/119) in colorectal cancer, 3.1% (1/32) in melanoma, 4% (1/25) in glioma, and 0.5% (2/411) in lung cancer, respectively. Significant correlations between the MSI-H and cancer types were found by χ2 test (χ2 = 26.571, Cramer’s V coefficient = 0.174, p = 3.980×10−4). Only patients with colorectal cancer had absolute values of adjusted standardized residual above 3, its observed counts of MSI-H significantly higher than expected counts. Fisher’s exact test was performed to analyze the differences of MSI-H ratio across hepatobiliary (liver and bile duct) cancer, digestive tract (gastric and colorectal) cancer and lung cancer, and we found the MSI-H ratio of patients with digestive duct cancer was significantly higher than patients with hepatobiliary cancer ( p = 0.007) or lung cancer ( p = 4.599×10−4). Conclusions: Our study provided new references to cancer-specific properties and clinical diagnosis of MSI especially in East Asian populations. As a retrospective study with a relatively small population, the conclusions of this study needed to be verified with a larger sample.

Correlation between TMB and MSI in patients with solid tumors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15169-e15169
Author(s):  
ZHENG ZHAO ◽  
Wentao Li ◽  
Xing Zhang ◽  
Minhui Ge ◽  
Chao Song
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Lung Cancer ◽  
Pancreatic Cancer ◽  
Bile Duct ◽  
Liver Cancer ◽  
Solid Tumors ◽  
Bile Duct Cancer ◽  
Predictive Biomarkers ◽  
Duct Cancer

e15169 Background: Both oftumor mutational burden (TMB) and microsatellite instability (MSI) are promising predictive biomarkers for immunotherapy in cancer treatment. However, the association between TMB and MSI with solid tumors was not well investigated especially in East Asian patients. Herein, the relationships for characterizing TMB and MSI in major cancer types were made. Methods: TMB and MSI were measured by 539 genes panel via NGS in tumor tissues. The TMB were calculated as the numbers of synonymous and nonsynonymous mutations, and InDels per megabase in coding regions. MSI was the gain or loss of nucleotides from repetitive DNA and the criteria of MSI-H were defined as above 10% positive of the 195 tested microsatellites sites, and this method was totally consistent with conventional MSI-PCR testing in Research and development sample verification. The relationships between TMB and MSI of 874 patients with solid tumors including 174 patients with liver cancer, 32 patients with bile duct cancer, 54 patients with gastric cancer, 119 patients with colorectal cancer, 27 patients with pancreatic cancer, 32 patients with melanoma, 25 patients with glioma and 411 patients with lung cancer cases were performed by Spearman rank correlation analysis via SPSS v22.0. Results: There was no significant correlation between TMB and MSI in total patients with solid tumors (r = 0.061, p = 0.073). Significantly correlations were observed in patients with colorectal cancer (r = 0.248, p = 0.006) and pancreatic cancer (r = 0.397, p = 0.040). Meanwhile, no significant correlations between TMB and MSI were identified in patients with liver cancer (r = -0.016, p = 0.830), bile duct cancer (r = 0.325, p = 0.070), gastric cancer (r = 0.209, p = 0.130), melanoma (r = -0.057, p = 0.757), glioma (r = 0.009, p = 0.967) and lung cancer (r = 0.015, p = 0.758). Interestingly, total eleven cases were confirmed as MSI high in patients with colorectal cancer, glioma and lung cancer all presented phenotypes of TMB high. Conclusions: We demonstrated the presence of tumor-specific properties correlations between TMB and MSI and provided new insights to use them as biomarkers in immunotherapy. As a retrospective study with a relatively small population, the conclusions of this study needed to be verified with a larger sample.

scholarly journals A Surgically Resected Case of Distal Bile Duct Cancer in situ Associated with Hyperplasia of the Bile Duct Epithelium

2015 ◽  
Vol 76 (11) ◽  
pp. 2794-2799
Author(s):  
Junya KAWASOE ◽  
Hidekazu YAMAMOTO ◽  
Takefumi YAZAWA ◽  
Hideki HARADA ◽  
Masazumi ZAIMA ◽  
...  
Keyword(s):  
Bile Duct ◽  
Bile Duct Cancer ◽  
Distal Bile Duct ◽  
Duct Epithelium ◽  
Bile Duct Epithelium ◽  
Duct Cancer ◽  
Resected Case
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