scholarly journals Concerns regarding meta-analysis and RCT selection about anticoagulants to treat sepsis-associated disseminated intravascular coagulation in the Japanese Surviving Sepsis Campaign Guidelines 2020

2022 ◽  
Vol 29 (1) ◽  
pp. 52-53
Author(s):  
Yutaka Umemura ◽  
Shigeki Kushimoto ◽  
Toshiaki Iba ◽  
Moritoki Egi ◽  
Hiroshi Ogura
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Meta Analysis ◽  
Surviving Sepsis Campaign ◽  
Intravascular Coagulation

scholarly journals The anticoagulant treatment for sepsis induced disseminated intravascular coagulation; network meta-analysis

2018 ◽  
Vol 171 ◽  
pp. 136-142 ◽  
Author(s):  
Tomoaki Yatabe ◽  
Shigeaki Inoue ◽  
So Sakamoto ◽  
Yuka Sumi ◽  
Osamu Nishida ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Meta Analysis ◽  
Anticoagulant Treatment ◽  
Intravascular Coagulation

scholarly journals Prognostic accuracy of different disseminated intravascular coagulation criteria in critically ill adult patients: a protocol for a systematic review and meta-analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e024878
Author(s):  
Jumpei Yoshimura ◽  
Kazuma Yamakawa ◽  
Akira Kodate ◽  
Mari Kodate ◽  
Satoshi Fujimi
Keyword(s):  
Systematic Review ◽  
Diagnostic Accuracy ◽  
Critically Ill ◽  
Disseminated Intravascular Coagulation ◽  
Scoring System ◽  
Meta Analysis ◽  
Adult Patients ◽  
Intravascular Coagulation ◽  
Operating Points ◽  
Receiver Operating

IntroductionDisseminated intravascular coagulation (DIC) is a common and serious condition that can lead to poor outcomes in critically ill patients. To make a correct diagnosis and improve the outcome of patients with DIC, several organisations have put forward DIC scoring systems. However, which criteria is the best to use for diagnosing DIC remains a continuing controversy even though many studies have been conducted to validate the diagnostic accuracy of each DIC scoring system.Methods and analysisWe will conduct a systematic review and meta-analysis of the diagnostic accuracy of DIC criteria for the prediction of mortality in critically ill adult patients. The primary objective is to assess the predictive values of the DIC criteria of Japanese Association for Acute Medicine, International Society on Thrombosis and Haemostasis, Japanese Ministry of Health and Welfare, Korean Society on Thrombosis and Hemostasis and Chinese Diagnostic Scoring System for 28-day mortality. We will search electronic bibliographic databases such as MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials. Two reviewers will independently screen titles and abstracts, perform full article reviews and extract study data. We will report study characteristics and assess methodological quality using the Quality of Diagnostic Accuracy Studies-II tool. If pooling is appropriate, we will compute parameter estimates using bivariate random-effects and hierarchical summary receiver operating characteristic models to produce summary receiver operating curves, summary operating points (pooled sensitivity and specificity) and 95% confidence regions around the summary operating points. Clinical and methodological subgroup and sensitivity analyses will be performed to explore heterogeneity.Ethics and disseminationThis systematic review will help physicians diagnose DIC accurately and improve their clinical practice in critically ill settings. Approval from an ethics committee is not required. The findings will be disseminated through publication in a peer-reviewed journal.PROSPERO registration numberCRD42017079350.

scholarly journals The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis

Critical Care ◽  
2022 ◽  
Vol 26 (1) ◽  
Author(s):  
Vanessa Catenacci ◽  
Fatima Sheikh ◽  
Kush Patel ◽  
Alison E. Fox-Robichaud
Keyword(s):  
Sensitivity And Specificity ◽  
Disseminated Intravascular Coagulation ◽  
Protein C ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Host Responses ◽  
Cochrane Library ◽  
Intravascular Coagulation ◽  
Prognostic Utility ◽  
Sepsis Survivors

Abstract Background Sepsis, the dysregulated host response to infection, triggers abnormal pro-coagulant and pro-inflammatory host responses. Limitations in early disease intervention highlight the need for effective diagnostic and prognostic biomarkers. Protein C’s role as an anticoagulant and anti-inflammatory molecule makes it an appealing target for sepsis biomarker studies. This meta-analysis aims to assess the diagnostic and prognostic value of protein C (PC) as a biomarker for adult sepsis. Methods We searched MEDLINE, PubMed, EMBASE, CINAHL and Cochrane Library from database inception to September 12, 2021. We included prospective observational studies of (1) adult patients (> 17) with sepsis or suspicion of sepsis that; (2) measured PC levels with 24 h of study admission with; and (3) the goal of examining PC as a diagnostic or prognostic biomarker. Two authors screened articles and conducted risk of bias (RoB) assessment, using the Quality in Prognosis Studies (QUIPS) and the Quality Assessment in Diagnostic Studies-2 (QUADAS-2) tools. If sufficient data were available, meta-analysis was conducted to estimate the standardized mean difference (SMD) between patient populations. Results Twelve studies were included, and 8 were synthesized for meta-analysis. Pooled analysis demonstrated moderate certainty of evidence that PC levels were less reduced in sepsis survivors compared to non-survivors (6 studies, 741 patients, SMD = 0.52, 95% CI 0.24–0.81, p = 0.0003, I2 = 55%), and low certainty of evidence that PC levels were less reduced in septic patients without disseminated intravascular coagulation (DIC) compared to those with DIC (3 studies, 644 patients, SMD = 0.97, 95% CI 0.62–1.32, p < 0.00001, I2 = 67%). PC could not be evaluated as a diagnostic tool due to heterogeneous control populations between studies. Conclusion and relevance Our review demonstrates that PC levels were significantly higher in sepsis survivors compared to non-survivors and patients with sepsis but not disseminated intravascular coagulation (DIC). Our evaluation is limited by high RoB in included studies and poor reporting of the sensitivity and specificity of PC as a sepsis biomarker. Future studies are needed to determine the sensitivity and specificity of PC to identify its clinical significance as a biomarker for early sepsis recognition. Trial Registration PROSPERO registration number: CRD42021229786. The study protocol was published in BMJ Open.

scholarly journals Incidence and impact of disseminated intravascular coagulation in COVID-19 a systematic review and meta-analysis

2021 ◽  
Vol 201 ◽  
pp. 23-29 ◽  
Author(s):  
Xianghui Zhou ◽  
Zhipeng Cheng ◽  
Lili Luo ◽  
Ying Zhu ◽  
Wenyi Lin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Disseminated Intravascular Coagulation ◽  
Meta Analysis ◽  
Intravascular Coagulation

scholarly journals Incidence and Impact of Disseminated Intravascular Coagulation in COVID-19

2020 ◽  
Author(s):  
Xianghui Zhou ◽  
Zhipeng Cheng ◽  
Lili Luo ◽  
Ying Zhu ◽  
Wenyi Lin ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Poor Prognosis ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Pooled Analysis ◽  
China National Knowledge Infrastructure ◽  
Intravascular Coagulation ◽  
Knowledge Infrastructure ◽  
Coagulation Dysfunction ◽  
Death Group

Abstract Background: Coronavirus disease 2019 (COVID-19) is a novel infectious disease, with significant morbidity and mortality. This meta-analysis is to evaluate the prevalence of disseminated intravascular coagulation (DIC) in COVID-19 patients and to determine the association of DIC with the severity and prognosis of COVID-19.Methods: We searched the PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) database until August 12, 2020. The meta-analysis was performed using Stata 16.0 software.Results: 15 studies were included in our meta-analysis. The pooled analysis revealed that the incidence of COVID-19 patients developing DIC was 4% (95%: 2%-5%, P<0.001). In addition, DIC was more likely to occur in the death group (Log OR = 2.4, 95% CI: 1.58-3.21, P<0.001) with statistical significance.Conclusions: DIC is associated with the severity and poor prognosis of COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Monitoring of coagulation indicators may improve the prognosis of COVID-19 inpatients.

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

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