scholarly journals Expression of trefoil factor 3 is decreased in colorectal cancer

2020 ◽  
Vol 45 (1) ◽  
pp. 254-264
Author(s):  
Ingrid Espinoza ◽  
Sumit Agarwal ◽  
Amit Reddy ◽  
Veena Shenoy ◽  
Charulochana Subramony ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Trefoil Factor ◽  
Trefoil Factor 3

Su1058 – Potential of Urinary Cysteine-Rich Protein 61 and Trefoil Factor 3 As Novel Biomarkers for the Detection of Colorectal Cancer

2019 ◽  
Vol 156 (6) ◽  
pp. S-498
Author(s):  
Takaya Shimura ◽  
Hiroyasu Iwasaki ◽  
Masahide Ebi ◽  
Tamaki Yamada ◽  
Tomonori Yamada ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Trefoil Factor ◽  
Cysteine Rich Protein ◽  
Trefoil Factor 3 ◽  
Novel Biomarkers

scholarly journals Urinary Cysteine-Rich Protein 61 and Trefoil Factor 3 as Diagnostic Biomarkers for Colorectal Cancer

2019 ◽  
Vol 12 (3) ◽  
pp. 539-544 ◽  
Author(s):  
Takaya Shimura ◽  
Hiroyasu Iwasaki ◽  
Mika Kitagawa ◽  
Masahide Ebi ◽  
Tamaki Yamada ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Trefoil Factor ◽  
Diagnostic Biomarkers ◽  
Cysteine Rich Protein ◽  
Trefoil Factor 3

scholarly journals Serum Trefoil Factor 3 as a Protein Biomarker for the Diagnosis of Colorectal Cancer

2016 ◽  
Vol 16 (4) ◽  
pp. 440-445 ◽  
Author(s):  
Qiang Li ◽  
Keke Wang ◽  
Chang Su ◽  
Jieyu Fang
Keyword(s):  
Colorectal Cancer ◽  
Diagnostic Accuracy ◽  
Receiver Operating Characteristic ◽  
Carcinoembryonic Antigen ◽  
Operating Characteristic ◽  
Tnm Stage ◽  
Healthy Controls ◽  
Trefoil Factor ◽  
Trefoil Factor 3 ◽  
Receiver Operating

Colorectal cancer is one of the most frequent causes of cancer-related deaths worldwide. Thus, there is a need for timely diagnosis and effective treatment. Our aim in the present study was to detect the serum level of trefoil factor 3 protein and evaluate the diagnostic accuracy of trefoil factor 3 in patients with colorectal cancer. We collected serum samples from 204 participants (127 patients with colorectal cancer, 35 patients with polyps, and 42 healthy controls). The levels of serum trefoil factor 3 and carcinoembryonic antigen expression were measured by enzyme-linked immunosorbent assay. Receiver operating characteristic curves were plotted to calculate the diagnostic accuracy of trefoil factor 3 in patients with colorectal cancer. The serum levels of trefoil factor 3 in patients with colorectal cancer (6.66 ± 2.4 ng/mL; P < .00l) and polyps (3.86 ± 1.3 ng/mL; P < .00l) were significantly increased compared to healthy controls (2.09 ± 1.0 ng/mL). Moreover, the area under the receiver operating characteristic curve for trefoil factor 3 was greater than carcinoembryonic antigen (0.889 vs 0.715). At a cutoff value of 5.591 ng/mL, the diagnostic sensitivity, specificity, and likelihood ratio of serum trefoil factor 3 for colorectal cancer was 74.2%, 94.8%, and 14.25, respectively. Furthermore, the serum trefoil factor 3 levels in early colorectal cancer (TNM stage I, 3.67 ± 1.27 ng/mL) were significantly increased compared to healthy controls ( P < .001); however, there was no significant difference compared to patients with polyps ( P = .576). We observed that the serum trefoil factor 3 levels decreased after surgery (6.66 ± 2.4 vs 4.48 ± 1.80 ng/mL; P < .001). In addition, high serum trefoil factor 3 levels were associated with poor tumor differentiation and clinical TNM stage ( P < .05). In conclusion, serum trefoil factor 3 is a promising biomarker for the diagnosis of colorectal cancer and prognosis of patients.

scholarly journals The value of trefoil factor 3 expression in predicting the long-term outcome and early recurrence of colorectal cancer

2014 ◽  
Vol 46 (2) ◽  
pp. 563-568 ◽  
Author(s):  
KIYOTO MORITO ◽  
JUN NAKAMURA ◽  
YOSHIHIKO KITAJIMA ◽  
KEITA KAI ◽  
TOMOKAZU TANAKA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Recurrence ◽  
Trefoil Factor ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Trefoil Factor 3

scholarly journals PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3

2012 ◽  
Vol 37 (12) ◽  
pp. 2671-2683 ◽  
Author(s):  
Hai-Shui Shi ◽  
Wei-Li Zhu ◽  
Jian-Feng Liu ◽  
Yi-Xiao Luo ◽  
Ji-Jian Si ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Basolateral Amygdala ◽  
Akt Signaling ◽  
Trefoil Factor ◽  
Akt Signaling Pathway ◽  
Trefoil Factor 3

167: Role of trefoil factor-3 peptide (TFF3) in prostate cancer progression

2014 ◽  
Vol 50 ◽  
pp. S37 ◽  
Author(s):  
M. Nowak ◽  
C. Merz ◽  
A. Von Maessenhausen ◽  
W. Vogel ◽  
D. Boehm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Trefoil Factor ◽  
Trefoil Factor 3
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